Protein Alignment Sp1 and SP9

DIOPT Version :10

• Sequence 1: NP_001259388.1
• Gene: Sp1 / 31913
• FlyBaseID: FBgn0020378
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_001138722.1
• Gene: SP9 / 100131390
• HGNCID: 30690
• Length: 484
• Species: Homo sapiens
• Alignment Length: 580
• Identity: 245/580 - (42%)
• Similarity: 290/580 - (50%)
• Gaps: 168/580 - (28%)

  Fly    39 DHPSLRGTPLAMLAAQCNKLSNKSP---PPLADAAVGKGFHPWKKSPNSPAAGSS--------GS 92
            :.|....||||||||.|||:.|.||   .|.:.|....||||||:|.:|...|||        |.
Human     8 EEPRFGTTPLAMLAATCNKIGNTSPLTTLPESSAFAKGGFHPWKRSSSSCNLGSSLSGFAVATGG 72

  Fly    93 SGGGGGGGGSSAGQHSPCAISAASSSSS-SGSSGGQSSRSLSSSASTMVNITASRPLASSCAAVG 156
            .|.||..|||.|...:.|..|.:.:||: |...||                     |.|:.||..
Human    73 RGSGGLAGGSGAANSAFCLASTSPTSSAFSSDYGG---------------------LFSNSAAAA 116

  Fly   157 GGSTGSSSSASGSQSSSTASAVAAAYGGDLYFPNTSTSNMDNHHMHQGLLGKVEAGAAAFGGVYS 221
            ..:.|.|...:|.||:                                .:.||...||  .|:|.
Human   117 AAAAGVSPQEAGGQSA--------------------------------FISKVHTTAA--DGLYP 147

  Fly   222 R----HPYDWPFNAVTHKEAAS------VNSGWWDMHSAAGSWLDM----GG-----------AG 261
            |    |||:..:.:..|...|:      ..|.|||:||:.||||::    ||           |.
Human   148 RVGMAHPYESWYKSGFHSTLAAGEVTNGAASSWWDVHSSPGSWLEVQNPAGGLQSSLHSGAPQAS 212

  Fly   262 MHSTMANYASENYSSALSHS----------------LLGSGQHLL-QDTYKSMLPGQGVGVGVGV 309
            :||.:..| :.::|| |:||                ||.:.|||| ||.:|.:||.
Human   213 LHSQLGTY-NPDFSS-LTHSAFSSTGLGSSAAAASHLLSTSQHLLAQDGFKPVLPS--------- 266

  Fly   310 GMGGFSLPHSSPSAAAAAAA-------TAAAAAGGSPQGGSPSTPSPRSQRRYAGRATCDCPNCQ 367
                    :|..|||.||||       .||||||||         |.||.|||:|||||||||||
Human   267 --------YSDSSAAVAAAAASAMISGAAAAAAGGS---------SARSARRYSGRATCDCPNCQ 314

  Fly   368 EAERLGPAGVHLRKKNIHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDEL 432
            |||||||||..||:|.:||||||||||||||||||||||||||||||||||||||||||||||||
Human   315 EAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDEL 379

  Fly   433 QRHLRTHTGEKRFACPVCNKRFMRSDHLAKHVKTHNGTANHQANGHNGGLKKGSSESCSDSEEAA 497
            ||||||||||||||||||||||||||||:||:|||||         .||.||| |:|.:|:....
Human   380 QRHLRTHTGEKRFACPVCNKRFMRSDHLSKHIKTHNG---------GGGGKKG-SDSDTDASNLE 434

  Fly   498 NQSGESNGL----GGVGSGPQTGGAGGGGGGSSSGNGAGTLAVSGSVTTGAGAGSGTGSS 553
            ....||..|    .||.:......|......:::...||          |..|.||...|
Human   435 TPRSESPDLILHDSGVSAARAAAAAAAAAAAAAAAASAG----------GKEAASGPNDS 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sp1	NP_001259388.1	SP6-9-like_N	50..386	CDD:411694	136/396 (34%)
		C2H2 Zn finger	390..409	CDD:275368	18/18 (100%)
		zf-H2C2_2	401..428	CDD:463886	26/26 (100%)
		C2H2 Zn finger	417..439	CDD:275368	21/21 (100%)
		zf-H2C2_2	431..454	CDD:463886	22/22 (100%)
		zf-C2H2	445..467	CDD:395048	19/21 (90%)
		C2H2 Zn finger	447..467	CDD:275368	17/19 (89%)
SP9	NP_001138722.1	SP9_N	19..333	CDD:411695	136/396 (34%)
		9aaTAD, inactive. /evidence=ECO:0000269|PubMed:31375868	178..186		5/7 (71%)
		C2H2 Zn finger	337..356	CDD:275368	18/18 (100%)
		zf-H2C2_2	348..375	CDD:463886	26/26 (100%)
		C2H2 Zn finger	364..386	CDD:275368	21/21 (100%)
		zf-H2C2_2	378..401	CDD:463886	22/22 (100%)
		zf-C2H2	392..414	CDD:395048	19/21 (90%)
		C2H2 Zn finger	394..414	CDD:275368	17/19 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	409..446		18/46 (39%)