DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btd and SWI5

DIOPT Version :9

Sequence 1:	NP_511100.1	Gene:	btd / 31912	FlyBaseID:	FBgn0000233	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_010430.1	Gene:	SWI5 / 851724	SGDID:	S000002553	Length:	709	Species:	Saccharomyces cerevisiae

Alignment Length:	548	Identity:	119/548 - (21%)
Similarity:	204/548 - (37%)	Gaps:	170/548 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 QQQHHLHMQQAQHHLHLSHQQAQQQHMQHLTQQQQQQQQQQQQQQQQQQQQQQPQQQQHDFLSAA 96
            |||..|..|          .:|||:..:.|..:.:|.|.:|||.|...:....||     |||..
Yeast   178 QQQQELREQ----------LRAQQEANKKLELELKQTQYKQQQLQATLENSDGPQ-----FLSPK 227

  Fly    97 ALLSAPPSLSGSSSGSSSGSSPLYGKPPMKLELPYPQASSTGTASPNSS-----IQSAPSSASVS 156
            ..:|  |:........::..||:. .|||.      ..|.||:.|..::     :|...||.:|.
Yeast   228 RKIS--PASENVEDVYANSLSPMI-SPPMS------NTSFTGSPSRRNNRQKYCLQRKNSSGTVG 283

  Fly   157 PSIF------------------PSPAQSFASIS--ASPSTPTTTLAPPTTAAAG----------- 190
            |..|                  .:|.::.:|.:  .:|.||.:.::..|:.:|.
Yeast   284 PLCFQELNEGFNDSLISPKKIRSNPNENLSSKTKFITPFTPKSRVSSATSNSANITPNNLRLDFK 348

  Fly   191 -------------------ALAGSPTSSSPSSSAASAAAAA------------------AAAAAA 218
                               .|.|.| ..||:.|.:..:|:.                  .:.:::
Yeast   349 INVEDQESEYSEKPLGLGIELLGKP-GPSPTKSVSLKSASVDIMPTIPGSVNNTPSVNKVSLSSS 412

  Fly   219 AAD--------LGAAAVASAAYGWNTAYSGLGPARSQFPYAQ-YASDYYGNAVGMSSSAAWFSHQ 274
            ..|        |..::::..|.|.|.|...|.|...|..:.: ..:|...|.:..::......::
Yeast   413 YIDQYTPRGKQLHFSSISENALGINAATPHLKPPSQQARHREGVFNDLDPNVLTKNTDNEGDDNE 477

  Fly   275 ERLYQPWS-------------SQS-YPGFNFDDIAFQTQLQRRSVRCT-CPN-CTNEMSGLPPIV 323
            |.  :|.|             ||| |.|   ....|.|.::..:...| .|: .|.:::.||
Yeast   478 EN--EPESRFVISETPSPVLKSQSKYEG---RSPQFGTHIKEINTYTTNSPSKITRKLTTLP--- 534

  Fly   324 GPDERGR----------KQHICHIPGCERLYGKASHLKTHLRWHTGERPFLC--LTCGKRFSRSD 376
                ||.          |...|..|||.:.:.:..::::|::.|..:||:.|  ..|.|.|.|:.
Yeast   535 ----RGSIDKYVKEMPDKTFECLFPGCTKTFKRRYNIRSHIQTHLEDRPYSCDHPGCDKAFVRNH 595

  Fly   377 ELQRHGRTHTNYRPYACPICSKKFSRSDHLSKHKKTHFKDKKSKKVLAAEAKEQAAAAIKLEKKE 441
            :|.||.::|.. :.|||| |.|||:|.|.|..|:         .:::.:..|:.....||  :..
Yeast   596 DLIRHKKSHQE-KAYACP-CGKKFNREDALVVHR---------SRMICSGGKKYENVVIK--RSP 647

  Fly   442 KKSGKPLTPPVEFKQEQPDTTPLVNYAP 469
            :|.|:|          :.|.|..|:.:|
Yeast   648 RKRGRP----------RKDGTSSVSSSP 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btd	NP_511100.1	C2H2 Zn finger	338..357	CDD:275368	4/18 (22%)
		zf-H2C2_2	349..374	CDD:290200	8/26 (31%)
		C2H2 Zn finger	365..385	CDD:275368	8/21 (38%)
		zf-H2C2_2	377..402	CDD:290200	12/24 (50%)
		zf-C2H2	391..413	CDD:278523	12/21 (57%)
		C2H2 Zn finger	393..413	CDD:275368	10/19 (53%)
SWI5	NP_010430.1	COG5048	124..630	CDD:227381	109/499 (22%)
		C2H2 Zn finger	552..574	CDD:275368	5/21 (24%)
		C2H2 Zn finger	582..604	CDD:275368	8/21 (38%)
		C2H2 Zn finger	611..627	CDD:275368	9/16 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	1	0.960