DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btd and Sp6

DIOPT Version :9

Sequence 1:	NP_511100.1	Gene:	btd / 31912	FlyBaseID:	FBgn0000233	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001350159.1	Gene:	Sp6 / 83395	MGIID:	1932575	Length:	376	Species:	Mus musculus

Alignment Length:	411	Identity:	127/411 - (30%)
Similarity:	168/411 - (40%)	Gaps:	128/411 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 SAPPSLS----GSSSGSSSGSSPLYGKP---------PMKLELPYPQASSTGTASPNSSIQSAPS 151
            ::||.|.    .:..|.:|..:..|..|         |:..|:.:.|......||...:.:...|
Mouse    19 ASPPRLDLQPLQTYQGHTSPEAGDYPSPLQPGELQSLPLGPEVDFSQGYELPGASSRVTCEDLES 83

  Fly   152 SASVSPSIF-----PSPAQSFASISASPSTPTT------TLAP-------PTTAAAGALAGSPTS 198
            .:.::|..|     |..:..:.| ...|:.|.|      .|.|       |.|..|....|.|.:
Mouse    84 DSPLAPGPFSKLLQPDMSHHYES-WFRPTHPGTEDGSWWDLHPGTSWMDLPHTQGALTSPGHPGA 147

  Fly   199 SSPSSSAASAAAAAAA-----------AAAAAADL-----GAAAVASAAYGWNTAYSGLGPARSQ 247
            ..|:...........|           .||....|     ||.|:.:||            ..||
Mouse   148 LQPALGGYVGDHQLCAPPPHPHPHHLLPAAGGQHLLGPPDGAKALEAAA------------QESQ 200

  Fly   248 FPYAQYASDYYGNAVGMSSSAAWFSHQERLYQPWSSQSYPGFNFDDIAFQTQLQRRSVR------ 306
                           |:.||.                        |.|.:.:..||||.
Mouse   201 ---------------GLDSSL------------------------DAASRPKGSRRSVPRSSGQT 226

  Fly   307 -CTCPNCTN-EMSGLPPIVGPDERGRKQHI--CHIPGCERLYGKASHLKTHLRWHTGERPFLC-- 365
             |.||||.. |..|.|  .||| .|:|:|:  ||||||.:.|.|.||||.|||||:|:|||:|
Mouse   227 VCRCPNCLEAERLGAP--CGPD-GGKKKHLHNCHIPGCGKAYAKTSHLKAHLRWHSGDRPFVCNW 288

  Fly   366 LTCGKRFSRSDELQRHGRTHTNYRPYACPICSKKFSRSDHLSKHKKTHFKDKKSKKVLAAEAKEQ 430
            |.|||||:||||||||.:|||..:.:.|.:||:.|.|||||:||.|||           ..|||:
Mouse   289 LFCGKRFTRSDELQRHLQTHTGTKKFPCAVCSRVFMRSDHLAKHMKTH-----------EGAKEE 342

  Fly   431 AAAAIKLEKKEKKSGKPLTPP 451
            ||||   .:.|.|:|..:.||
Mouse   343 AAAA---AQGEGKAGGVVEPP 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btd	NP_511100.1	C2H2 Zn finger	338..357	CDD:275368	12/18 (67%)
		zf-H2C2_2	349..374	CDD:290200	19/26 (73%)
		C2H2 Zn finger	365..385	CDD:275368	15/21 (71%)
		zf-H2C2_2	377..402	CDD:290200	12/24 (50%)
		zf-C2H2	391..413	CDD:278523	12/21 (57%)
		C2H2 Zn finger	393..413	CDD:275368	12/19 (63%)
Sp6	NP_001350159.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..70		10/50 (20%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:Q3SY56	118..126		1/7 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	164..224		19/110 (17%)
		C2H2 Zn finger	259..278	CDD:275368	12/18 (67%)
		COG5048	<261..>336	CDD:227381	46/74 (62%)
		C2H2 Zn finger	286..308	CDD:275368	15/21 (71%)
		C2H2 Zn finger	316..336	CDD:275368	12/19 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	334..376		15/41 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870