DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment btd and SP6

DIOPT Version :9

Sequence 1:NP_511100.1 Gene:btd / 31912 FlyBaseID:FBgn0000233 Length:644 Species:Drosophila melanogaster
Sequence 2:NP_001245177.1 Gene:SP6 / 80320 HGNCID:14530 Length:376 Species:Homo sapiens


Alignment Length:411 Identity:123/411 - (29%)
Similarity:164/411 - (39%) Gaps:128/411 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   100 SAPPSLS----GSSSGSSSGSSPLYGKP---------PMKLELPYPQASSTGTASPNSSIQSAPS 151
            ::||.|.    .:..|.:|..:..|..|         |:..|:.:.|......||...:.:...|
Human    19 ASPPRLDLQPLQTYQGHTSPEAGDYPSPLQPGELQSLPLGPEVDFSQGYELPGASSRVTCEDLES 83

  Fly   152 SASVSPSIF-----PSPAQSFASISASPSTP-------------TTTLAPPTTAAAGALAGSP-- 196
            .:.::|..|     |..:..:.| ...|:.|             |:.:..|.|..|....|.|  
Human    84 DSPLAPGPFSKLLQPDMSHHYES-WFRPTHPGAEDGSWWDLHPGTSWMDLPHTQGALTSPGHPGA 147

  Fly   197 --------------TSSSPSSSAASAAAAAAAAAAAAADLGAAAVASAAYGWNTAYSGLGPARSQ 247
                          .:..|...|.....||..........||.|:..||                
Human   148 LQAGLGGYVGDHQLCAPPPHPHAHHLLPAAGGQHLLGPPDGAKALEVAA---------------- 196

  Fly   248 FPYAQYASDYYGNAVGMSSSAAWFSHQERLYQPWSSQSYPGFNFDDIAFQTQLQRRSVR------ 306
             |.:|          |:.||.                        |.|.:.:..||||.      
Human   197 -PESQ----------GLDSSL------------------------DGAARPKGSRRSVPRSSGQT 226

  Fly   307 -CTCPNCTN-EMSGLPPIVGPDERGRKQHI--CHIPGCERLYGKASHLKTHLRWHTGERPFLC-- 365
             |.||||.. |..|.|  .||| .|:|:|:  ||||||.:.|.|.||||.|||||:|:|||:|  
Human   227 VCRCPNCLEAERLGAP--CGPD-GGKKKHLHNCHIPGCGKAYAKTSHLKAHLRWHSGDRPFVCNW 288

  Fly   366 LTCGKRFSRSDELQRHGRTHTNYRPYACPICSKKFSRSDHLSKHKKTHFKDKKSKKVLAAEAKEQ 430
            |.|||||:||||||||.:|||..:.:.|.:||:.|.|||||:||.|||           ..|||:
Human   289 LFCGKRFTRSDELQRHLQTHTGTKKFPCAVCSRVFMRSDHLAKHMKTH-----------EGAKEE 342

  Fly   431 AAAAIKLEKKEKKSGKPLTPP 451
            ||.|   ...|.|:|..:.||
Human   343 AAGA---ASGEGKAGGAVEPP 360

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btdNP_511100.1 C2H2 Zn finger 338..357 CDD:275368 12/18 (67%)
zf-H2C2_2 349..374 CDD:290200 19/26 (73%)
C2H2 Zn finger 365..385 CDD:275368 15/21 (71%)
zf-H2C2_2 377..402 CDD:290200 12/24 (50%)
zf-C2H2 391..413 CDD:278523 12/21 (57%)
C2H2 Zn finger 393..413 CDD:275368 12/19 (63%)
SP6NP_001245177.1 SP6_N 1..255 CDD:411693 59/290 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..70 10/50 (20%)
9aaTAD. /evidence=ECO:0000269|PubMed:31375868 118..126 0/7 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 167..223 19/106 (18%)
C2H2 Zn finger 259..278 CDD:275368 12/18 (67%)
COG5048 <261..>336 CDD:227381 46/74 (62%)
C2H2 Zn finger 286..308 CDD:275368 15/21 (71%)
C2H2 Zn finger 316..336 CDD:275368 12/19 (63%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 333..376 14/42 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
21.870

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