DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment btd and SP3

DIOPT Version :9

Sequence 1:NP_511100.1 Gene:btd / 31912 FlyBaseID:FBgn0000233 Length:644 Species:Drosophila melanogaster
Sequence 2:NP_003102.1 Gene:SP3 / 6670 HGNCID:11208 Length:781 Species:Homo sapiens


Alignment Length:515 Identity:147/515 - (28%)
Similarity:196/515 - (38%) Gaps:161/515 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 DAACNYL-NPYAQQHQAQQQQHAQHQQHAQQQQHHLHMQQAQHHLHLSHQQAQQQHMQHLTQQ-- 64
            |...||: :|.:::.|||..|.:.    ||....||.:|::|      ...:|.|.:|.:|.|  
Human   367 DLQGNYIQSPVSEETQAQNIQVST----AQPVVQHLQLQESQ------QPTSQAQIVQGITPQTI 421

  Fly    65 ---QQQQQQQQQQQQQQQQQQQQPQQQQHDFLSAAALLSAPPSLSGSSSGSSSGSSPLYGKPPMK 126
               |...|...||..|..|.|..|    ..||..|..::                          
Human   422 HGVQASGQNISQQALQNLQLQLNP----GTFLIQAQTVT-------------------------- 456

  Fly   127 LELPYPQASSTGTASPNSSIQSAPSSASVSPSIFPSPAQSFASISASPSTPTTTLAPPTTAAAGA 191
                 |....|........:|:..:.     .|..:.||...      .||..||.....||.||
Human   457 -----PSGQVTWQTFQVQGVQNLQNL-----QIQNTAAQQIT------LTPVQTLTLGQVAAGGA 505

  Fly   192 LAGSPTSSSPSSSAASAAAAAAAAAAAAADLGAAAVASAAYGWNTAYSGLGPARSQFPYAQYASD 256
            ...:|.|.|.............:..:|...|.....|.:            ||..:         
Human   506 FTSTPVSLSTGQLPNLQTVTVNSIDSAGIQLHPGENADS------------PADIR--------- 549

  Fly   257 YYGNAVGMSSSAAWFSHQERLYQPWSSQSYPGFNFDDIA--------------FQTQLQRRSVRC 307
                          ...:|...:.|........|.:|:.              .|...:.|.|.|
Human   550 --------------IKEEEPDPEEWQLSGDSTLNTNDLTHLRVQVVDEEGDQQHQEGKRLRRVAC 600

  Fly   308 TCPNCTNEMSGLPPIVGPDERGRKQHICHIPGCERLYGKASHLKTHLRWHTGERPFLC--LTCGK 370
            ||||| .|..|....:|.    :||||||||||.::|||.|||:.|||||:|||||:|  :.|||
Human   601 TCPNC-KEGGGRGTNLGK----KKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFVCNWMYCGK 660

  Fly   371 RFSRSDELQRHGRTHTNYRPYACPICSKKFSRSDHLSKHKKTHFKDKK----SKKVLAAEAKEQA 431
            ||:||||||||.||||..:.:.||.|||:|.|||||:||.||| ::||    |..|||:      
Human   661 RFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTH-QNKKGIHSSSTVLAS------ 718

  Fly   432 AAAIKLEKKEKKSGKPLTPPVEFKQEQPDT------TPLVNYAPYANLYQHSTSAGSSVN 485
                                ||..::  ||      |.|:    .||:.|.|.|...:||
Human   719 --------------------VEAARD--DTLITAGGTTLI----LANIQQGSVSGIGTVN 752

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btdNP_511100.1 C2H2 Zn finger 338..357 CDD:275368 12/18 (67%)
zf-H2C2_2 349..374 CDD:290200 18/26 (69%)
C2H2 Zn finger 365..385 CDD:275368 15/21 (71%)
zf-H2C2_2 377..402 CDD:290200 15/24 (63%)
zf-C2H2 391..413 CDD:278523 14/21 (67%)
C2H2 Zn finger 393..413 CDD:275368 14/19 (74%)
SP3NP_003102.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..53
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 65..88
Transactivation domain (Gln-rich) 138..237
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 301..338
Transactivation domain (Gln-rich) 350..499 40/187 (21%)
9aaTAD. /evidence=ECO:0000269|PubMed:31375868 461..469 1/7 (14%)
Repressor domain 534..620 20/125 (16%)
C2H2 Zn finger 623..645 CDD:275368 15/21 (71%)
COG5048 <636..718 CDD:227381 52/82 (63%)
zf-H2C2_2 637..664 CDD:290200 18/26 (69%)
C2H2 Zn finger 653..675 CDD:275368 15/21 (71%)
zf-H2C2_2 667..690 CDD:290200 14/22 (64%)
zf-C2H2 681..703 CDD:278523 14/21 (67%)
C2H2 Zn finger 683..703 CDD:275368 14/19 (74%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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