DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btd and SP2

DIOPT Version :9

Sequence 1:	NP_511100.1	Gene:	btd / 31912	FlyBaseID:	FBgn0000233	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	XP_011523438.1	Gene:	SP2 / 6668	HGNCID:	11207	Length:	771	Species:	Homo sapiens

Alignment Length:	370	Identity:	114/370 - (30%)
Similarity:	163/370 - (44%)	Gaps:	116/370 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 SPLYGKPPM--KLELPYPQASSTGTAS-PNSSIQSAPSSASVSPSIFPSPAQSFASISASPSTPT 178
            ||..|:|.:  ::::..|:|....... |..:::...::::..|::...|:|:| .|.|:..|||
Human   393 SPGGGQPAVVQQVQVVPPKAEQQQVVQIPQQALRVVQAASATLPTVPQKPSQNF-QIQAAEPTPT 456

  Fly   179 ------------TTL---APPTTAAA--GALAGSPTSSSPSSSAASAAAAAA-----------AA 215
                        |.|   :||.||||  .....||.|.:|..|..|...:||           |.
Human   457 QVYIRTPSGEVQTVLVQDSPPATAAATSNTTCSSPASRAPHLSGTSKKHSAAILRKERPLPKIAP 521

  Fly   216 AAAAADLGAAAVASAAY----------------------------------GWNTAYSGLGPARS 246
            |.:...|.||.:|:||.                                  |.|...|||.|.:.
Human   522 AGSIISLNAAQLAAAAQAMQTININGVQVQGVPVTITNTGGQQQLTVQNVSGNNLTISGLSPTQI 586

  Fly   247 QFPYAQYASDYYGNAVGMSSSAAWFSHQERLYQPWSSQSYPGFNFDDIAFQTQLQRRSVRCTCPN 311
            |.                           ::.|..:.::.||           .:||.:.|||||
Human   587 QL---------------------------QMEQALAGETQPG-----------EKRRRMACTCPN 613

  Fly   312 CTN--EMSGLPPIVGPDERGRKQHICHIPGCERLYGKASHLKTHLRWHTGERPFLC--LTCGKRF 372
            |.:  :.||        |:|:|:|:||||.|.:.:.|.|.|:.|:|.|||||||:|  ..|||||
Human   614 CKDGEKRSG--------EQGKKKHVCHIPDCGKTFRKTSLLRAHVRLHTGERPFVCNWFFCGKRF 670

  Fly   373 SRSDELQRHGRTHTNYRPYACPICSKKFSRSDHLSKHKKTHFKDK 417
            :||||||||.||||..:.:.|..|.|:|.|||||:||.|||...|
Human   671 TRSDELQRHARTHTGDKRFECAQCQKRFMRSDHLTKHYKTHLVTK 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btd	NP_511100.1	C2H2 Zn finger	338..357	CDD:275368	7/18 (39%)
		zf-H2C2_2	349..374	CDD:290200	16/26 (62%)
		C2H2 Zn finger	365..385	CDD:275368	15/21 (71%)
		zf-H2C2_2	377..402	CDD:290200	13/24 (54%)
		zf-C2H2	391..413	CDD:278523	12/21 (57%)
		C2H2 Zn finger	393..413	CDD:275368	12/19 (63%)
SP2	XP_011523438.1	COG5048	<553..718	CDD:227381	74/209 (35%)
		zf-C2H2	629..653	CDD:278523	11/23 (48%)
		C2H2 Zn finger	634..653	CDD:275368	7/18 (39%)
		zf-H2C2_2	646..672	CDD:290200	16/25 (64%)
		C2H2 Zn finger	661..683	CDD:275368	15/21 (71%)
		zf-H2C2_2	675..698	CDD:290200	12/22 (55%)
		zf-C2H2	689..711	CDD:278523	12/21 (57%)
		C2H2 Zn finger	691..711	CDD:275368	12/19 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910