Protein Alignment btd and SP1

DIOPT Version :9

• Sequence 1: NP_511100.1
• Gene: btd / 31912
• FlyBaseID: FBgn0000233
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_612482.2
• Gene: SP1 / 6667
• HGNCID: 11205
• Length: 785
• Species: Homo sapiens
• Alignment Length: 383
• Identity: 138/383 - (36%)
• Similarity: 189/383 - (49%)
• Gaps: 63/383 - (16%)

  Fly    60 HLTQQQQQQQQQQQQQQQQQQQQQQPQQQQHDFLSAAALLSAPPSLSGSSSGSSSGSSPLYGKPP 124
            ::.|.|......|..||::.:|.||.||||        :|..|..:.|..:..:..::||.|
Human   369 NIQQNQTSGGSLQAGQQKEGEQNQQTQQQQ--------ILIQPQLVQGGQALQALQAAPLSG--- 422

  Fly   125 MKLELPYPQASSTGTASPNSSIQSAPSSASV---SPSIFPSPAQSFASIS------ASPSTPTTT 180
               :....||.|..|.. |..:|:.|:|..:   :|::.|:...|:.::.      .:|...|.|
Human   423 ---QTFTTQAISQETLQ-NLQLQAVPNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNPQAQTIT 483

  Fly   181 LAPPTTAAAGALAGSPTSSSPSSSAASAAAAAAAAAAAAADLGAAAVASAAYGWNTA-YSGLGPA 244
            |||....:.|..:.|.|:.:|.:||||..|......||.        .|:..|..|. .|.||.:
Human   484 LAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQ--------LSSMPGLQTINLSALGTS 540

  Fly   245 RSQ------FPYA-QYASDYYGNAVGMSSSAAWFSHQERLYQPWSSQSYPGFNFDDIAFQTQLQR 302
            ..|      .|.| ..|...:|..:|:..:.....|.:      ::....|.|..|.  |.|..|
Human   541 GIQVHPIQGLPLAIANAPGDHGAQLGLHGAGGDGIHDD------TAGGEEGENSPDA--QPQAGR 597

  Fly   303 RSVR--CTCPNCTNEM---SGLPPIVGPDERGRKQHICHIPGCERLYGKASHLKTHLRWHTGERP 362
            |:.|  ||||.|.:..   ||       |...:|||||||.||.::|||.|||:.||||||||||
Human   598 RTRREACTCPYCKDSEGRGSG-------DPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERP 655

  Fly   363 FLCL--TCGKRFSRSDELQRHGRTHTNYRPYACPICSKKFSRSDHLSKHKKTHFKDKK 418
            |:|.  .|||||:||||||||.||||..:.:|||.|.|:|.||||||||.||| ::||
Human   656 FMCTWSYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTH-QNKK 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
btd	NP_511100.1	C2H2 Zn finger	338..357	CDD:275368	11/18 (61%)
		zf-H2C2_2	349..374	CDD:290200	19/26 (73%)
		C2H2 Zn finger	365..385	CDD:275368	15/21 (71%)
		zf-H2C2_2	377..402	CDD:290200	15/24 (63%)
		zf-C2H2	391..413	CDD:278523	15/21 (71%)
		C2H2 Zn finger	393..413	CDD:275368	14/19 (74%)
SP1	NP_612482.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..93
		Repressor domain	2..82
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	109..141
		Transactivation domain A (Gln-rich)	146..251
		Transactivation domain B (Gln-rich)	261..495		36/140 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	329..395		8/25 (32%)
		9aaTAD. /evidence=ECO:0000269|PubMed:31375868	462..470		1/7 (14%)
		Transactivation domain C (highly charged)	496..610		35/129 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	567..598		6/38 (16%)
		VZV IE62-binding	619..785		64/95 (67%)
		C2H2 Zn finger	628..650	CDD:275368	14/21 (67%)
		zf-H2C2_2	642..669	CDD:290200	19/26 (73%)
		C2H2 Zn finger	658..680	CDD:275368	15/21 (71%)
		zf-H2C2_2	672..695	CDD:290200	14/22 (64%)
		zf-C2H2	686..708	CDD:278523	15/21 (71%)
		C2H2 Zn finger	688..708	CDD:275368	14/19 (74%)
		Domain D	708..785		3/6 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910