DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btd and Sp3

DIOPT Version :9

Sequence 1:	NP_511100.1	Gene:	btd / 31912	FlyBaseID:	FBgn0000233	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	XP_038962304.1	Gene:	Sp3 / 367846	RGDID:	1583765	Length:	781	Species:	Rattus norvegicus

Alignment Length:	514	Identity:	145/514 - (28%)
Similarity:	197/514 - (38%)	Gaps:	159/514 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DAACNYL-NPYAQQHQAQQQQHAQHQQHAQQQQHHLHMQQAQHHLHLSHQQAQQQHMQHLTQQ-- 64
            |...||: :|.:::.|||..|.:.    ||....||.:|.:|      ...:|.|.:|.:|.|
  Rat   367 DLQGNYIQSPVSEETQAQNIQVST----AQPVVQHLQLQDSQ------QPTSQAQIVQGITPQTI 421

  Fly    65 ---QQQQQQQQQQQQQQQQQQQQPQQQQHDFLSAAALLSAPPSLSGSSSGSSSGSSPLYGKPPMK 126
               |...|...||..|..|.|..|    ..||..|..::
  Rat   422 HGVQASGQNISQQALQNLQLQLNP----GTFLIQAQTVT-------------------------- 456

  Fly   127 LELPYPQASSTGTASPNSSIQSAPSSASVSPSIFPSPAQSFASISASPSTPTTTLAPPTTAAAGA 191
                 |....|........:|:..:.     .|..:.||...      .||..||.....||.||
  Rat   457 -----PSGQITWQTFQVQGVQNLQNL-----QIQNTAAQQIT------LTPVQTLTLGQVAAGGA 505

  Fly   192 LAGSPTSSSPSSSAASAAAAAAAAAAAAADLGAAAVASAAYGWNTAYSGLGPARSQFPYAQYASD 256
            |..:|.|.|                                            ..|.|..|..:.
  Rat   506 LTSTPVSLS--------------------------------------------TGQLPNLQTVTV 526

  Fly   257 YYGNAVGM-------SSSAAWFSHQERLYQP--WSSQSYPGFNFDDIA--------------FQT 298
            ...::.|:       :.|.|....:|....|  |........|.:|:.              .|.
  Rat   527 NSIDSTGIQLHPGENADSPADIRIKEEEPDPEEWQLSGDSTLNTNDLTHLRVQVVDEEGDQQHQE 591

  Fly   299 QLQRRSVRCTCPNCTNEMSGLPPIVGPDERGRKQHICHIPGCERLYGKASHLKTHLRWHTGERPF 363
            ..:.|.|.|||||| .|..|....:|.    :||||||||||.::|||.|||:.|||||:|||||
  Rat   592 GKRLRRVACTCPNC-KEGGGRGTNLGK----KKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPF 651

  Fly   364 LC--LTCGKRFSRSDELQRHGRTHTNYRPYACPICSKKFSRSDHLSKHKKTHFKDKKSKKVLAAE 426
            :|  :.|||||:||||||||.||||..:.:.||.|||:|.|||||:||.|||    ::|||:.:.
  Rat   652 ICNWMFCGKRFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTH----QNKKVIHSS 712

  Fly   427 AKEQAAAAIKLEKKEKKSGKPLTPPVEFKQEQPDTTPLVNYAPYANLYQHSTSAGSSVN 485
            :...|:.....:.....:|              .||.::     ||:.|.|.|...:||
  Rat   713 STVLASVEAGRDDALITAG--------------GTTLIL-----ANIQQGSVSGIGTVN 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btd	NP_511100.1	C2H2 Zn finger	338..357	CDD:275368	12/18 (67%)
		zf-H2C2_2	349..374	CDD:290200	18/26 (69%)
		C2H2 Zn finger	365..385	CDD:275368	15/21 (71%)
		zf-H2C2_2	377..402	CDD:290200	15/24 (63%)
		zf-C2H2	391..413	CDD:278523	14/21 (67%)
		C2H2 Zn finger	393..413	CDD:275368	14/19 (74%)
Sp3	XP_038962304.1	SP3_N	51..622	CDD:411774	73/359 (20%)
		zf-C2H2	621..645	CDD:395048	17/23 (74%)
		C2H2 Zn finger	623..645	CDD:275368	15/21 (71%)
		zf-C2H2	651..675	CDD:395048	16/23 (70%)
		C2H2 Zn finger	653..675	CDD:275368	15/21 (71%)
		zf-H2C2_2	667..690	CDD:404364	14/22 (64%)
		zf-C2H2	681..703	CDD:395048	14/21 (67%)
		C2H2 Zn finger	683..703	CDD:275368	14/19 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910