DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btd and hsr1

DIOPT Version :9

Sequence 1:	NP_511100.1	Gene:	btd / 31912	FlyBaseID:	FBgn0000233	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_593553.1	Gene:	hsr1 / 2543251	PomBaseID:	SPAC3H1.11	Length:	582	Species:	Schizosaccharomyces pombe

Alignment Length:	519	Identity:	114/519 - (21%)
Similarity:	187/519 - (36%)	Gaps:	135/519 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NYLNPYAQQHQAQQQQHAQHQQHAQQQQ-------HHLHMQQAQHHL---HLSHQQAQQQHMQ-- 59
            |...|..|.....:.:.||:.|.:|...       :..:...|||:|   ..||.:|.|.:|.
pombe   141 NGFQPPPQNPGISKSRIAQYHQPSQTYDDTVDSSFYDWYKAGAQHNLAPPQSSHTEASQGYMYST 205

  Fly    60 ---------------HLTQQQQQQQQQQQQQQQQQQQQQQPQQQQHDFLSAAALLSAPPSLSGSS 109
                           :.||.......|:...|...:.:...|.|.:       ||.|.|:::..:
pombe   206 NTAHDATDIPSSFNFYNTQASTAPNPQEINYQWSHEYRPHTQYQNN-------LLRAQPNVNCEN 263

  Fly   110 SGSSSGSSPLYGKPPMKLELPYPQASSTGTASPNSSIQSAPSSASVSPSIFPSPAQSFAS--ISA 172
            ..:   :.|.|         |:.|.|    .:||:.:   ||..::...:.|||..:.:|  :|.
pombe   264 FPT---TVPNY---------PFQQPS----YNPNALV---PSYTTLVSQLPPSPCLTVSSGPLST 309

  Fly   173 SPSTPTTTLAPPTTAAAGALAGSPTSSSPSSSAASAAAAAAAAAAAAADLGAAAVASAAYGWNTA 237
            :.|.|:....|           |..||.||..|.......:.         ...:.|.:|.....
pombe   310 ASSIPSNCSCP-----------SVKSSGPSYHAEQEVNVNSY---------NGGIPSTSYNDTPQ 354

  Fly   238 YSGLGPARSQFPYAQYASDYYGNAVGMSSSAAWFSHQERLYQPWSSQSYPGFNFDDIAFQTQLQR 302
            .|..|...|....:.|.:.  .|..|.|.::...:.|                ...|.....::|
pombe   355 QSVTGSYNSGETMSTYLNQ--TNTSGRSPNSMEATEQ----------------IGTIGTDGSMKR 401

  Fly   303 RSVRCTCPNCTNEMSGLPPIVGPDERGRKQHICHIPGCERLYGKASHLKTHLR-WHTGERPFLCL 366
            |..|    ..:|..:.:     |...|.|..:|  |.|.:.:.::.||:.|:| .||.|:||:|:
pombe   402 RKRR----QPSNRKTSV-----PRSPGGKSFVC--PECSKKFKRSEHLRRHIRSLHTSEKPFVCI 455

  Fly   367 TCGKRFSRSDELQRHGRTHTNYRP-YAC---------------PICSKK---------FSRSDHL 406
             |||||||.|.|::|.|.|.|..| .||               |:..:|         .::....
pombe   456 -CGKRFSRRDNLRQHERLHVNASPRLACFFQPSGYYSSGAPGAPVQPQKPIEDLNKIPINQGMDS 519

  Fly   407 SKHKKTHFKDKKSKKVLAAEAKEQAAAAIKLEKKEKKSGKPLTPPVEFKQEQPDTTPLVNYAPY 470
            |:.:.|:.. ..|::.|:.:...:.||.....:.|..|..|:..|   .|:.|...|:..|.||
pombe   520 SQIENTNLM-LSSQRPLSQQIVPEIAAYPNSIRPELLSKLPVQTP---NQKMPLMNPMHQYQPY 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btd	NP_511100.1	C2H2 Zn finger	338..357	CDD:275368	6/19 (32%)
		zf-H2C2_2	349..374	CDD:290200	15/25 (60%)
		C2H2 Zn finger	365..385	CDD:275368	12/19 (63%)
		zf-H2C2_2	377..402	CDD:290200	10/49 (20%)
		zf-C2H2	391..413	CDD:278523	5/45 (11%)
		C2H2 Zn finger	393..413	CDD:275368	4/43 (9%)
hsr1	NP_593553.1	COG5048	103..582	CDD:227381	114/519 (22%)
		zf-C2H2	423..444	CDD:278523	6/22 (27%)
		C2H2 Zn finger	425..446	CDD:275368	7/22 (32%)
		zf-H2C2_2	437..462	CDD:290200	15/25 (60%)
		C2H2 Zn finger	454..473	CDD:275368	12/19 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	67	1.000	Inparanoid score	I1951
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	2.010