DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btd and EGR1

DIOPT Version :9

Sequence 1:	NP_511100.1	Gene:	btd / 31912	FlyBaseID:	FBgn0000233	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001955.1	Gene:	EGR1 / 1958	HGNCID:	3238	Length:	543	Species:	Homo sapiens

Alignment Length:	537	Identity:	142/537 - (26%)
Similarity:	203/537 - (37%)	Gaps:	135/537 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 FLSAAALLSAPPSLSGSSSGSSSG-------------SSPLY------GKPPMK----------- 126
            ||.||   .||.....:||.||||             ||..:      |:.|.:
Human    48 FLGAA---GAPEGSGSNSSSSSSGGGGGGGGGSNSSSSSSTFNPQADTGEQPYEHLTAESFPDIS 109

  Fly   127 -------LELPYPQASS-------TGTAS----PNS-----------------SIQSAPSSASVS 156
                   :|..||..::       ||..|    |||                 |:.:.|:|:|.:
Human   110 LNNEKVLVETSYPSQTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPASSSSA 174

  Fly   157 PSIFPSPAQSFASISASPSTPTTTLAPPTTAAAGALAGSPTSSSPSSS--AASAAAAAAAAAAAA 219
                ||||.|.||.|.|   |..:.|.|:..::...:.:||..:|::.  ....:.|...:|..|
Human   175 ----PSPAASSASASQS---PPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTA 232

  Fly   220 ADLGAAAVASAAYGWNTAYSGLGPARSQFPYAQYASDYYGNAVGMSSSAAWFSHQERLYQP---- 280
            ......|..:|..|:..      |....:.:.|...|.   .:|......:...:.|..||
Human   233 LQYPPPAYPAAKGGFQV------PMIPDYLFPQQQGDL---GLGTPDQKPFQGLESRTQQPSLTP 288

  Fly   281 ----------WSSQSYPGFNFDDIAFQTQLQRRSVRCTCPNCTNEMSGLPPIVGPDERGRKQHIC 335
                      ..||.....|   .::|:||.:.|.....||       .|....|.||   .:.|
Human   289 LSTIKAFATQSGSQDLKALN---TSYQSQLIKPSRMRKYPN-------RPSKTPPHER---PYAC 340

  Fly   336 HIPGCERLYGKASHLKTHLRWHTGERPFLCLTCGKRFSRSDELQRHGRTHTNYRPYACPICSKKF 400
            .:..|:|.:.::..|..|:|.|||::||.|..|.:.|||||.|..|.||||..:|:||.||.:||
Human   341 PVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKF 405

  Fly   401 SRSDHLSKHKKTHF--KDKKSKKVLAAEAKEQAAAAIKLEKKEKKSGKPLTPPVEFKQEQPDTTP 463
            :|||...:|.|.|.  ||||:.|.:.|     ::|...|.............||......|.||.
Human   406 ARSDERKRHTKIHLRQKDKKADKSVVA-----SSATSSLSSYPSPVATSYPSPVTTSYPSPATTS 465

  Fly   464 LVNYAPYANLYQHSTSAGSSVNPPP-----PPPPLFQQQMTTTTSSAAASFVEQPWSSSSSRAIQ 523
            ..:..|.:     .:|.|||..|.|     |.|     .:.||.||...:|..|..|..||....
Human   466 YPSPVPTS-----FSSPGSSTYPSPVHSGFPSP-----SVATTYSSVPPAFPAQVSSFPSSAVTN 520

  Fly   524 PATTSASSSSSSSASSP 540
            ..:.|...|..::..||
Human   521 SFSASTGLSDMTATFSP 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btd	NP_511100.1	C2H2 Zn finger	338..357	CDD:275368	5/18 (28%)
		zf-H2C2_2	349..374	CDD:290200	11/24 (46%)
		C2H2 Zn finger	365..385	CDD:275368	10/19 (53%)
		zf-H2C2_2	377..402	CDD:290200	13/24 (54%)
		zf-C2H2	391..413	CDD:278523	11/21 (52%)
		C2H2 Zn finger	393..413	CDD:275368	10/19 (53%)
EGR1	NP_001955.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..105		16/59 (27%)
		DUF3446	135..209	CDD:314753	22/80 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..213		17/54 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..284		2/22 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..339		7/30 (23%)
		zf-C2H2	338..362	CDD:306579	6/23 (26%)
		C2H2 Zn finger	340..362	CDD:275368	6/21 (29%)
		zf-H2C2_2	354..379	CDD:316026	11/24 (46%)
		C2H2 Zn finger	370..390	CDD:275368	10/19 (53%)
		zf-H2C2_2	382..407	CDD:316026	13/24 (54%)
		C2H2 Zn finger	398..418	CDD:275368	10/19 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	409..487		24/87 (28%)
		DUF3432	447..530	CDD:288743	24/92 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I4604
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960