DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment btd and ZNF526

DIOPT Version :9

Sequence 1:	NP_511100.1	Gene:	btd / 31912	FlyBaseID:	FBgn0000233	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001300962.1	Gene:	ZNF526 / 116115	HGNCID:	29415	Length:	670	Species:	Homo sapiens

Alignment Length:	256	Identity:	71/256 - (27%)
Similarity:	105/256 - (41%)	Gaps:	72/256 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 CPNCTNEMSGLP-------PIVGPDERGRKQHICHIPGCERLYGKASHLKTHLRWHTGERPFLCL 366
            ||.|:...:...       .:.||.||   :|.|.:  |.:.:.|..|::.|||.|||||||.|.
Human   444 CPQCSKSFASASRLSRHRRAVHGPPER---RHRCGV--CGKGFKKLIHVRNHLRTHTGERPFQCH 503

  Fly   367 TCGKRFSRSDELQRHGRTHTNYRPYACPICSKKFSRSDHLSKHKKTHFKDKKSKKVLAAEAKEQA 431
            :|||.|:....|.||..|||..|||.|..|.|:|::|.:|.:|::.|.:
Human   504 SCGKTFASLANLSRHQLTHTGARPYQCLDCGKRFTQSSNLQQHRRLHLR---------------- 552

  Fly   432 AAAIKLEKKEKKSGKPLTPPVEF-KQEQPDTTPLVNYAPY--------------ANLYQ--HSTS 479
                               ||.| :..:...|.|.|.:||              ..|:|  |:.:
Human   553 -------------------PVAFARAPRLPITGLYNKSPYYCGTCGRWFRAMAGLRLHQRVHARA 598

  Fly   480 AGSSVNPP------PPPPPLFQQQMTTTTSSAAASFVE--QPWSSSSSRAIQPATTSASSS 532
            ...::.||      |||||..||.:..|......:.:|  ||.:...:..:..|...||.:
Human   599 RTLTLQPPRSPSPAPPPPPEPQQTIMCTELGETIAIIETSQPLALEDTLQLCQAALGASEA 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btd	NP_511100.1	C2H2 Zn finger	338..357	CDD:275368	6/18 (33%)
		zf-H2C2_2	349..374	CDD:290200	16/24 (67%)
		C2H2 Zn finger	365..385	CDD:275368	8/19 (42%)
		zf-H2C2_2	377..402	CDD:290200	13/24 (54%)
		zf-C2H2	391..413	CDD:278523	8/21 (38%)
		C2H2 Zn finger	393..413	CDD:275368	7/19 (37%)
ZNF526	NP_001300962.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	168..196
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..304
		C2H2 Zn finger	275..296	CDD:275368
		C2H2 Zn finger	307..327	CDD:275368
		C2H2 Zn finger	334..354	CDD:275368
		C2H2 Zn finger	362..382	CDD:275368
		C2H2 Zn finger	390..409	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	409..443
		COG5048	<441..550	CDD:227381	43/110 (39%)
		C2H2 Zn finger	444..464	CDD:275368	3/19 (16%)
		C2H2 Zn finger	474..494	CDD:275368	7/21 (33%)
		zf-H2C2_2	486..511	CDD:290200	16/24 (67%)
		C2H2 Zn finger	502..522	CDD:275368	8/19 (42%)
		zf-H2C2_2	514..539	CDD:290200	13/24 (54%)
		C2H2 Zn finger	530..550	CDD:275368	7/19 (37%)
		C2H2 Zn finger	575..595	CDD:275368	2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	601..621		7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4673
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950