DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TAAR6 and npr-22

DIOPT Version :9

Sequence 1:	NP_778237.1	Gene:	TAAR6 / 319100	HGNCID:	20978	Length:	345	Species:	Homo sapiens
Sequence 2:	NP_001023541.1	Gene:	npr-22 / 190424	WormBaseID:	WBGene00022004	Length:	434	Species:	Caenorhabditis elegans

Alignment Length:	331	Identity:	80/331 - (24%)
Similarity:	139/331 - (41%)	Gaps:	69/331 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    28 SPGSRVILYIVFGFGAVLAVFGNLLVMISILHFKQLHSPTNFLVASLACADFLVGVTVMPFSMVR 92
            :|..:::..:.:....|..|:||:||::.|::||:|.:.||.|:.:||.||.|:.|..:|||..:
Worm    46 TPSMKMLCILFYSILCVCCVYGNVLVILVIVYFKRLRTATNILILNLAVADLLISVFCIPFSYWQ 110

Human    93 TV---ESCWYFGRSFCTFHTCCDVAFCYSSLFHLCFISIDRYIAVTDPLVYPTKFTVSVSGICIS 154
            .:   :..|.||...|:..........:.|.:.|..||.||::|:...|....:.|...:...::
Worm   111 VLIYDDQRWLFGSMMCSLLAFLQAMAVFLSAWTLVVISFDRWMAIMFLLTPNIRITRRRALYLVA 175

Human   155 VSWI------LPLMYSGAVFYTGVYDDGLEELSDALNCIGGCQTVVNQNWV-------------- 199
            .:||      |||:::...|..   .|||.      ||        .:||.
Worm   176 ATWIFSILMALPLLFTTRFFED---QDGLP------NC--------GENWTYFGDSGEQVRKVYS 223

Human   200 -LTDFLSFFIPTFIMIILYGNIFLVARRQAKKIENTGSKTESSSESYKARVARRE--RKAAKTLG 261
             :...|.:.:|..::||.|.:|.:       |:.|:......:..:.|..|.|.|  :|....:.
Worm   224 SMVLILQYVVPQAVLIITYTHIGI-------KMWNSRVPGMQNGATKKMIVDRHESVKKLVPMVI 281

Human   262 VTVVAFMISWLPYSIDSLIDAFMGFITPACIYEICCW------------CAYYNSAMNPLIYALF 314
            :....|.:.|||..|  ||:     :.|....:|..|            .|..:|.:||:||.:.
Worm   282 LISALFALCWLPLLI--LIN-----VIPEFYPDINSWGYILYLWWFAHGLAMSHSMVNPIIYFIR 339

Human   315 YPWFRK 320
            ...||:
Worm   340 NARFRE 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TAAR6	NP_778237.1	7tm_4	43..>271	CDD:304433	62/253 (25%)
TAAR6	NP_778237.1	7tm_1	49..311	CDD:278431	73/299 (24%)
npr-22	NP_001023541.1	7tmA_PR4-like	51..347	CDD:320514	79/326 (24%)
		TM helix 1	52..78	CDD:320514	7/25 (28%)
		TM helix 2	85..110	CDD:320514	12/24 (50%)
		TM helix 3	126..156	CDD:320514	8/29 (28%)
		TM helix 4	169..190	CDD:320514	5/20 (25%)
		TM helix 5	219..248	CDD:320514	6/35 (17%)
		TM helix 6	271..301	CDD:320514	9/36 (25%)
		TM helix 7	315..340	CDD:320514	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910