DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TAAR6 and ser-5

DIOPT Version :9

Sequence 1:	NP_778237.1	Gene:	TAAR6 / 319100	HGNCID:	20978	Length:	345	Species:	Homo sapiens
Sequence 2:	NP_492273.2	Gene:	ser-5 / 184572	WormBaseID:	WBGene00008890	Length:	454	Species:	Caenorhabditis elegans

Alignment Length:	339	Identity:	106/339 - (31%)
Similarity:	149/339 - (43%)	Gaps:	67/339 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    29 PGSRVILYIVFGFGAVLAVFGNLLVMISILHFKQLHSPTN--FLVASLACADFLVGVTVMPFSMV 91
            |...|:|.|......:|.:||||||    |.||.....||  .||.:|...||||||.|:|...|
Worm    59 PAVLVLLCIPAVIIILLTIFGNLLV----LFFKARVGRTNTTLLVWNLGLTDFLVGVIVLPMGAV 119

Human    92 RTVESCWYFGRSFCTFHTCCDVAFCYSSLFHLCFISIDRYIAVTDPLVYPTKFTVSVSGICISVS 156
            ..:...|.|||..|......||.||..|:..:|.||:|||:|||.||.|.:..|.:.....:::.
Worm   120 YLIYRKWIFGRFLCRLWVAADVTFCTCSVVTICVISVDRYLAVTRPLRYKSIVTKTKVISVMTII 184

Human   157 WILPLMYSGAVFYTGV-------YDDGLEELSDALNCIGG------CQTVVNQNWVLTDFLSFFI 208
            ||    :|.::..|.|       |||.|        |..|      ..:||         .:||:
Worm   185 WI----FSSSILLTTVRWEQPECYDDSL--------CFVGNEIRHLAHSVV---------FAFFL 228

Human   209 PTFIMIILYGNIFLVARRQAKKIE---------------NTGS----------KTESSSESYKAR 248
            |..:.:.||..|:.:||.:.|.::               ||.|          ||....| ::.|
Worm   229 PASVTLTLYWRIYKLARNRQKALDRGFLMILGSNMNFLTNTLSQQTTLRVHFGKTNGMVE-HQRR 292

Human   249 VARRERKAAKTLGVTVVAFMISWLPYSIDSLIDAFMGFITPACIYEICCWCAYYNSAMNPLIYAL 313
            |.|...:.||||||...:|:..|||:....|.:.......|....::..|..|.||.:||:||:.
Worm   293 VLRTHERIAKTLGVVSCSFLFCWLPFFGLYLTNYKCSGCVPPIAIDVASWLGYCNSMLNPIIYSF 357

Human   314 FYPWF-RKAIKVIV 326
            ....| |.|.:::|
Worm   358 TVKEFKRSAFRLVV 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TAAR6	NP_778237.1	7tm_4	43..>271	CDD:304433	85/267 (32%)
TAAR6	NP_778237.1	7tm_1	49..311	CDD:278431	94/301 (31%)
ser-5	NP_492273.2	7tmA_amine_R-like	64..365	CDD:320098	101/326 (31%)
		TM helix 1	65..87	CDD:320098	10/25 (40%)
		TM helix 2	96..118	CDD:320098	11/21 (52%)
		TM helix 3	134..156	CDD:320098	7/21 (33%)
		TM helix 4	179..195	CDD:320098	3/19 (16%)
		TM helix 5	215..238	CDD:320098	6/31 (19%)
		TM helix 6	298..323	CDD:320098	10/24 (42%)
		TM helix 7	334..359	CDD:320098	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910