DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TAAR6 and kiss1r

DIOPT Version :9

Sequence 1:	NP_778237.1	Gene:	TAAR6 / 319100	HGNCID:	20978	Length:	345	Species:	Homo sapiens
Sequence 2:	NP_001163985.1	Gene:	kiss1r / 100316929	XenbaseID:	XB-GENE-990075	Length:	366	Species:	Xenopus tropicalis

Alignment Length:	375	Identity:	94/375 - (25%)
Similarity:	156/375 - (41%)	Gaps:	50/375 - (13%)

- Green bases have known domain annotations that are detailed below.

Human     4 NSSLLVAVQLCYANVNGSCVKI--------PFSPGSRVILYIVFGFGAVL---AVFGNLLVMISI 57
            |.||......|...:...|..:        |..|...|..::|..|.|:|   .:.||.||:..|
Frog     3 NESLFSFNDSCLGGMVYLCTNMSDLEKYGDPPRPPQLVDAWLVPLFFAMLMLVGLTGNSLVIYVI 67

Human    58 LHFKQLHSPTNFLVASLACADFLVGVTVMPFSMVRTVESCWYFGRSFCTFHTCCDVAFCYSSLFH 122
            ...||:.:.|||.:|:||..|.:..|:.:||:........|.||...|.|..........::...
Frog    68 SKHKQMRTVTNFYIANLAATDIIFLVSCVPFTAALYPLPGWIFGEFMCKFVNYIQQVSVQATCVT 132

Human   123 LCFISIDRYIAVTDPLVYPTKFTVSVSGICISVS-WILPLMYSGAVFYTGVYDDGLEE--LSDAL 184
            |..:|:||:.....||....:.|..|:. .:||. ||...:.|..|   .:|:..:|.  ....:
Frog   133 LTAMSVDRWYVTVYPLQSLRQRTPRVAA-AVSVGIWIGSFIVSIPV---PIYNQLIEGYWFGPQI 193

Human   185 NCIGGCQTVVNQN-WVLTDFL-SFFIPTFIMIILY-GNIFLVARRQAKKIENTGSKTESSSESYK 246
            .|.....:|.::. ::|.:|| .:.:|...:.|.| ..::.:.|...:.::|          ||:
Frog   194 YCSESFPSVSHEKAFILYNFLVVYLLPLITICICYSAMVYQMGRPSVEPVDN----------SYQ 248

Human   247 AR-VARRER----KAAKTLGVTVVAFMISWLPYSIDSLIDAFM-GFITPACIYEICCWC---AYY 302
            .: :|.|..    |.::.:.|.|:.|.|.|.|..:..|..||. .|......|::..|.   :|.
Frog   249 VQLLAERSELMRTKISRMVAVIVLLFTICWGPIQLYILFQAFSPSFKRDYYTYKVKIWANCMSYT 313

Human   303 NSAMNPLIYALFYPWFRKAI----------KVIVTGQVLKNSSATMNLFS 342
            ||::||::||.....||||.          :|..||....|::..|:..|
Frog   314 NSSINPIVYAFMGANFRKAFNKVFPFLFKQRVGSTGVANANANTEMHFVS 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TAAR6	NP_778237.1	7tm_4	43..>271	CDD:304433	59/241 (24%)
TAAR6	NP_778237.1	7tm_1	49..311	CDD:278431	70/276 (25%)
kiss1r	NP_001163985.1	7tmA_KiSS1R	43..333	CDD:320223	79/303 (26%)
		TM helix 1	44..70	CDD:320223	9/25 (36%)
		TM helix 2	77..103	CDD:320223	10/25 (40%)
		TM helix 3	115..145	CDD:320223	6/29 (21%)
		TM helix 4	157..177	CDD:320223	6/20 (30%)
		TM helix 5	205..234	CDD:320223	6/28 (21%)
		TM helix 6	258..288	CDD:320223	8/29 (28%)
		TM helix 7	301..326	CDD:320223	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910