DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TAAR6 and drd1c

DIOPT Version :9

Sequence 1:	NP_778237.1	Gene:	TAAR6 / 319100	HGNCID:	20978	Length:	345	Species:	Homo sapiens
Sequence 2:	XP_004915948.1	Gene:	drd1c / 100124855	XenbaseID:	XB-GENE-5919679	Length:	465	Species:	Xenopus tropicalis

Alignment Length:	353	Identity:	105/353 - (29%)
Similarity:	169/353 - (47%)	Gaps:	38/353 - (10%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSSNSSLLVAVQLCYA--NVNGSCVKIPFSPGSRVILYIVFGFGAVLAVFGNLLVMISILHFKQL 63
            |.:.|...|.|.:.:|  :|..|.:.:      |.:..::.....:..:.||.||.::::.|:.|
Frog     1 MENLSIYNVTVNVLHADLDVGSSDLSL------RALTGLLLSLLILSTLLGNTLVCLAVIKFRHL 59

Human    64 HSP-TNFLVASLACADFLVGVTVMPFSMVRTVESCWYFGRSFCTFHTCCDVAFCYSSLFHLCFIS 127
            .|. |||.|.|||.:|..|.:.|||:..|..|...|.|| .||......|:....:|:.:||.||
Frog    60 RSKVTNFFVISLAVSDLFVALLVMPWKAVTEVAGYWLFG-DFCDTWVAFDIMCSTASILNLCIIS 123

Human   128 IDRYIAVTDPLVYPTKFTVSVSGICISVSWILPLMYSGAVFYTGVYDDGLEELSDALNCIG---G 189
            :|||.|:..|..|..|.|..|:.|.|.|:|.|.::.|........:..  :|:.:.||.|.   .
Frog   124 LDRYWAIASPFRYERKMTQRVAFIMIGVAWTLSILISFIPVQLSWHKS--QEVDEELNAINHTEN 186

Human   190 CQTVVNQNWVL-TDFLSFFIPTFIMIILYGNIFLVARRQAKKIEN---------TGSKTESSSES 244
            |.:.:|:.:.: :..:||:||..|||..|..|:.:|:.|.::|.:         :|....|:..|
Frog   187 CDSSLNRTYAISSSLISFYIPVVIMIGTYTRIYRIAQTQIRRISSLERAVEHAQSGHPDCSNENS 251

Human   245 YKARVARRERKAAKTLGVTVVAFMISWLPYSIDSLIDAFMGFITPA-------CI----YEICCW 298
            .|... |:|.|..|||.:.:..|:..|||:.:.:.:..|.....|.       |:    :.|..|
Frog   252 LKTSF-RKETKVLKTLSIIMGVFVFCWLPFFVLNCMIPFCHMSLPGQNEPEPPCVSETTFNIFVW 315

Human   299 CAYYNSAMNPLIYALFYPWFRKAIKVIV 326
            ..:.||::||:||| |...||||...|:
Frog   316 FGWANSSLNPVIYA-FNADFRKAFTTIL 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TAAR6	NP_778237.1	7tm_4	43..>271	CDD:304433	76/241 (32%)
TAAR6	NP_778237.1	7tm_1	49..311	CDD:278431	88/286 (31%)
drd1c	XP_004915948.1	7tmA_D1-like_dopamine_R	46..338	CDD:320185	94/296 (32%)
		TM helix 2	64..91	CDD:320185	13/26 (50%)
		TM helix 3	101..131	CDD:320185	11/29 (38%)
		TM helix 4	143..163	CDD:320185	7/19 (37%)
		TM helix 5	192..222	CDD:320185	10/29 (34%)
		TM helix 6	257..287	CDD:320185	10/29 (34%)
		TM helix 7	307..332	CDD:320185	10/25 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910