DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3106 and CG16723

DIOPT Version :9

Sequence 1:	NP_001285060.1	Gene:	CG3106 / 31909	FlyBaseID:	FBgn0030148	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_651159.3	Gene:	CG16723 / 42781	FlyBaseID:	FBgn0039092	Length:	695	Species:	Drosophila melanogaster

Alignment Length:	709	Identity:	227/709 - (32%)
Similarity:	365/709 - (51%)	Gaps:	64/709 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MMEHFGVLAVVLLIATA---VGAQDTSSNYLLTGHSTPLASSFAHQFF------TLASQSAELAN 56
            |:...|||....|:||.   :...|.|..|.......||...|| :||      :|....::||:
  Fly     1 MVNVVGVLLFYGLVATCALELTDPDVSKTYEYISQLRPLGLEFA-EFFKNVTLESLGVSDSKLAS 64

  Fly    57 RTNTQVIQTYEDRNYDDELCDRDINLIRDSINNLEEWALEFPDTWGRLPMGLFWGHTISMGQYEE 121
            .              :||||..::..:.:.|:..|.|||:..|.||.:|.||..|:...:|.::|
  Fly    65 A--------------EDELCSVELAAVMNGISLRETWALKMIDAWGSIPNGLLTGNLFDLGNFDE 115

  Fly   122 CVAASS-THTTEIRGQYCLASLNITTFYQSVKKRGEEFSRISYKQTDPEVFELGICVPKTCSAAK 185
            |::... .....|||::|....|..                          .:..|.|.:||:.:
  Fly   116 CLSIEKVVGGKRIRGKFCFLLANSA--------------------------RIATCFPASCSSTQ 154

  Fly   186 TEKLLKYAITHFYGQDVMESNYTM-VTEARCKYDAPIELRGIDIFAIIFFSLIIFFMVASSVYDY 249
            .|..::..:...   ::..|:..| ::.|.|:........|:.||.|:..||:...:::.:::||
  Fly   155 METFVEQLMALI---NLNSSSLKMRISGASCQTSEIEPWNGLTIFTIVILSLMCVIVISVTIFDY 216

  Fly   250 IQTRKGAPKKPLLIAFSVLTNAPKIF-TVKKVNNPNVIHCLNGLRCFSMMWVVFGHGYMTFYDLP 313
            ...........::..||...|:..:| .|...:|||||.|.:|:||.::.||::.|.::.|...|
  Fly   217 FLCDDPRSIPAVVKTFSARANSRALFRIVPNKSNPNVIECFHGIRCMTLFWVIYCHEFIFFLTSP 281

  Fly   314 HINKNKFYTWVQTPYSMLVQNGSLCVDTFFFMSGLLMCWGAFREMERTKGKLNIPMMYFHRYIRL 378
            ::|:...|||...|:|..|.:|...||:||.:.|||:...:.|.||::.|:||..:||.||.:|:
  Fly   282 NLNRLDLYTWTVKPFSSFVLHGYFAVDSFFVLGGLLVSMISLRSMEKSGGRLNPVLMYLHRILRI 346

  Fly   379 TPVVAVVVLYIMSLYKYSGAGPMWFKLGTQD-KRCADTWWATLIYVQNYAFPYSICISQSWYLAV 442
            .||||:.:|..|::......||| .|.|... :.|.:.|:.||:::||||. .:||:..:|||||
  Fly   347 LPVVAIAILIYMTMMTVVSGGPM-LKNGYHGMEYCLNGWFWTLLFIQNYAV-QNICLDHTWYLAV 409

  Fly   443 DTQLYFLSPLFLIPLWKWGKKALVPIVIVLILCLGGTFATFMLNDFT-LFRVQDDQVDLRQRLTY 506
            |.||:.:||:.|:.|:.|||||...|.::::|..|..|||.|:|.:| |.::.|....:..:..|
  Fly   410 DMQLFIISPILLMALYNWGKKAASGIAVLVVLLSGCLFATQMVNHYTLLIKINDGDDGVPNKKLY 474

  Fly   507 YPTHTRIPTWLIGVIFGYFLFTRNRGRQIPMSKPLVLTGWFVAFGTMLACMWGPYWRILPDTPDS 571
            ..|||....||||.:|||||.. |||::..:|:|:|..||.::...:...::..|.......|..
  Fly   475 LATHTHAAPWLIGFLFGYFLHI-NRGKKFQLSRPIVWLGWILSLAMLFTSIFALYPASQLTAPPL 538

  Fly   572 PLIEGAFFEPLSRTSWALSIGWIVWACYNGHGGLVNDFLSWGFFTGFSRLCYCMYVIHRIVQLVN 636
            ..:|.:.:..|:|.:|.|:|.||::||..|:|||.|.|||...:...|||.|.||:.|..||.||
  Fly   539 STLEESLYYTLTRLAWPLAICWIIFACMQGYGGLANSFLSTPLWQPLSRLSYSMYIWHMFVQEVN 603

  Fly   637 AARLQTDTHFSNYDAILRWWHDFGITLTASIFATLAFEAPILGIEKAIFGK---PAPKK 692
            :..::|:|:|:||.|:.|:.:|.|.|:..|....|..|||:.|.:..:.|:   |||.|
  Fly   604 SRNVRTNTYFTNYIAMERFCYDLGFTVLMSYILYLIIEAPLCGFDSILRGRKDPPAPNK 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3106	NP_001285060.1	NRF	91..217	CDD:214781	28/127 (22%)
		Acyl_transf_3	286..635	CDD:280013	135/350 (39%)
		OafA	289..702	CDD:224748	156/409 (38%)
CG16723	NP_651159.3	NRF	87..184	CDD:214781	27/125 (22%)
		Acyl_transf_3	254..599	CDD:280013	133/347 (38%)
		OafA	291..644	CDD:224748	138/355 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458077
Domainoid	1	1.000	50	1.000	Domainoid score	I11639
eggNOG	1	0.900	-	-		E1_KOG3700
Homologene	1	1.000	-	-		H129774
Inparanoid	1	1.050	178	1.000	Inparanoid score	I4016
Isobase	1	0.950	-	0	Normalized mean entropy	S7984
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	1	1.000	-	-		FOG0001682
OrthoInspector	1	1.000	-	-		otm25504
orthoMCL	1	0.900	-	-		OOG6_100705
Panther	1	1.100	-	-	P	PTHR11161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X299
	13	12.750