DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3106 and CG10182

DIOPT Version :9

Sequence 1:	NP_001285060.1	Gene:	CG3106 / 31909	FlyBaseID:	FBgn0030148	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_651158.1	Gene:	CG10182 / 42780	FlyBaseID:	FBgn0039091	Length:	699	Species:	Drosophila melanogaster

Alignment Length:	753	Identity:	233/753 - (30%)
Similarity:	374/753 - (49%)	Gaps:	94/753 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLIATAVGAQDTSSNYLLTGHSTPLASSFAHQFFTLASQSAELANRTNTQVIQTYEDR--NYDDE 74
            |:.|..:..:|..|:.........||..|..|           ....:.:.:.|.|.|  :.:|.
  Fly    15 LISAGRLNDEDVLSDLQRVSQLKGLALDFVGQ-----------VKDFDVEELSTLETRVPSQEDM 68

  Fly    75 LCDRDINLIRDSINNLEEWALEFPDTWGRLPMGLFWGHTISMGQYEECVAASSTHTTE----IRG 135
            ||..|:..:...:.:.:.|||:..|:||.:|.||..|:...:|.::||:  :..|...    |:|
  Fly    69 LCLSDLTALTTGLQSGQYWALKMFDSWGSIPSGLLTGNMYDLGNFDECL--NINHGVSLGRTIQG 131

  Fly   136 QYCLASLNITTFYQSVKKRGEEFSRISYKQTDPEVFELGICVPKTCSAA--------KTEKLLKY 192
            :||..|:::      .:..|.:.|.|.:       |:...|:|.:|||.        .|::||..
  Fly   132 KYCFLSVSL------AQALGVQSSIIGH-------FKTATCLPASCSATYMNTFMGMVTKQLLNV 183

  Fly   193 AITHFYGQDVMESNYTMVTEARCKYDAPIELRGIDIFAIIFFSLIIFFMVASSVYDYIQTRKGAP 257
            :|         .|:...::|:.|:....:...|:.||.|:..|::...:...:::||. ..|...
  Fly   184 SI---------PSSVMSISESSCQTSESVPWDGLTIFMIVILSVMGSLVALFTLWDYC-LGKNQD 238

  Fly   258 KKPLLI-AFSVLTNAPKIFTVKKVN-NPNVIHCLNGLRCFSMMWVVFGHGYMTFYDLPHINKNKF 320
            :.|.:: .||...|:..:|.:.:|| :||||.||:|:||.|:|||||.|.|:......:||....
  Fly   239 QLPTIVKVFSARVNSRALFRIVEVNSSPNVIDCLHGIRCLSLMWVVFCHQYVMAALASNINIFHA 303

  Fly   321 YTWVQTPYSMLVQNGSLCVDTFFFMSGLLMCWGAFREMERTKGKLNIPMMYFHRYIRLTPVVAVV 385
            .:|.:|||:..:.:|...||:||.:.|||:.....|.|:|||||||:|:||.||.||:.|::|:.
  Fly   304 ISWEETPYASFILHGFFSVDSFFVLGGLLVALIPLRMMDRTKGKLNVPLMYLHRLIRIVPLLAIA 368

  Fly   386 VLYIMSLYKYSGAGPMWFK--LGTQDKRCADTWWATLIYVQNYAFPYSICISQSWYLAVDTQLYF 448
            ::..:.|......||.:..  .||.|  |.:.|:.||::|.||.  ...|:..:|||:||.||:.
  Fly   369 IVMYLKLMPIVADGPRFGSGYSGTVD--CENGWYWTLLFVNNYT--EEKCLGHTWYLSVDMQLFI 429

  Fly   449 LSPLFLIPLWKWGKKALVPIVIVLILCLGGTFATFMLNDFTL----FRVQDDQVDLRQRLTYYPT 509
            |||:.||.|:||||||...|.::::|..|..|||.|:|.::|    |.: |.|.||     |:.|
  Fly   430 LSPIMLIALYKWGKKAAAGIFVLIVLLSGCLFATIMVNKYSLVLKNFSM-DAQKDL-----YFAT 488

  Fly   510 HTRIPTWLIGVIFGYFLFTRNRGRQIPMSKPLVLTGWFVAFGTMLACMWG--PY--WRILPDTPD 570
            ||....||.|.:|||.|.. |||::..:||.:..:||.:....:...::.  ||  |    ..||
  Fly   489 HTHATPWLTGFLFGYSLHL-NRGKKFQLSKVVAWSGWILCLAMIFTSIFALYPYAKW----TGPD 548

  Fly   571 SPLIEGAFFEPLSRTSWALSIGWIVWACYNGHGGLVNDFLSWGFFTGFSRLCYCMYVIHRIVQLV 635
            ......|.:..|:|..|.:::.|:::||.||:|||.|.|||...:...|||.|.:|:.|...|.:
  Fly   549 LSTFAEASYYTLTRVGWCMALCWVIFACMNGYGGLANSFLSSPLWQPLSRLSYSVYMWHMFFQEI 613

  Fly   636 NAARLQTDTHFSNYDAILRWWHDFGITLTASIFATLAFEAPILGIEKAIFGKPAPKKPSPGELAK 700
            |...::|:::||||..:|.:|..||..:..:....|..|||..|::  .|.:|..|.|
  Fly   614 NIRSMRTNSYFSNYTIMLNFWSTFGFAVLFAYVMHLVIEAPFGGLD--YFLRPKQKTP------- 669

  Fly   701 AAPVAATSASAEPEPEAKPESVVETKTEIAPVPTNEEN 738
              |:....:..:.......|.:..|      .||..||
  Fly   670 --PLVKQKSQIDDNGHNNLEELKVT------TPTPAEN 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3106	NP_001285060.1	NRF	91..217	CDD:214781	35/137 (26%)
		Acyl_transf_3	286..635	CDD:280013	139/358 (39%)
		OafA	289..702	CDD:224748	156/422 (37%)
CG10182	NP_651158.1	NRF	85..186	CDD:214781	32/124 (26%)
		Acyl_transf_3	269..645	CDD:280013	149/390 (38%)
		OafA	300..655	CDD:224748	136/369 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458083
Domainoid	1	1.000	50	1.000	Domainoid score	I11639
eggNOG	1	0.900	-	-		E1_KOG3700
Homologene	1	1.000	-	-		H129774
Inparanoid	1	1.050	178	1.000	Inparanoid score	I4016
Isobase	1	0.950	-	0	Normalized mean entropy	S7984
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	1	1.000	-	-		FOG0001682
OrthoInspector	1	1.000	-	-		otm25504
orthoMCL	1	0.900	-	-		OOG6_100705
Panther	1	1.100	-	-	P	PTHR11161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X299
	13	12.750