DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3106 and CG14219

DIOPT Version :9

Sequence 1:	NP_001285060.1	Gene:	CG3106 / 31909	FlyBaseID:	FBgn0030148	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_608322.1	Gene:	CG14219 / 32951	FlyBaseID:	FBgn0031033	Length:	724	Species:	Drosophila melanogaster

Alignment Length:	760	Identity:	254/760 - (33%)
Similarity:	400/760 - (52%)	Gaps:	85/760 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VLLIATAVGAQDT-----SSNYLLTGH------------STPLASSFAHQFFTLASQSAELANRT 58
            :|.:|.:|.||.|     ::..|||.|            :..|:..|...:..:..:  :|...:
  Fly    12 LLALAKSVNAQMTNIFAMTNTKLLTEHIAGGDHYSSIFNTRRLSVEFFEHYANVTLE--DLTANS 74

  Fly    59 NTQV--IQTYEDRNYDDELCDRDINLIRDSINNLEEWALEFPDTWGRLPMGLFWGHTISMGQYEE 121
            |:::  :|..|        |..|:.|:...:::.:.|||:..|:||.||.|:..|:..::|.::|
  Fly    75 NSRIPSLQDLE--------CLADLALLSKDLSSFKFWALKMIDSWGLLPSGMLAGNWWNLGNFDE 131

  Fly   122 CV----AASSTHTTEIRGQYCLASLNITTFYQSVKKRGEEFSRISYKQTDPEVFEL-----GICV 177
            |:    |.:|:|:  |:|:||:..|.                      ..|.:..:     .:|.
  Fly   132 CIAIDHAVTSSHS--IKGKYCITKLT----------------------PAPSLLPILALKSAVCF 172

  Fly   178 PKTCSAAKTEKLLKYAITHFYGQDVMESNYTMVTEARCKYDAPIELRGIDIFAIIFFSLIIFFMV 242
            |.|||||..:.:|:.........:: :::..:|.|..|:........|:.||.|:..|::...:.
  Fly   173 PATCSAANMDTMLRRLFQKLLTVEI-DADVQIVAEETCQTAVKKPYDGLAIFTIVIVSILGAIVG 236

  Fly   243 ASSVYDYIQTRKGAPKKPLLIAFSVLTNAPKIFTVKKVN-NPNVIHCLNGLRCFSMMWVVFGHGY 306
            ..:::||...:......|::.|||...|:..:|.:.... |||||.||:|:||.|.:|||:||.|
  Fly   237 VCTIFDYFFCKDEKTIHPVVEAFSARANSRALFRIVDTKANPNVIDCLHGIRCLSFIWVVYGHDY 301

  Fly   307 MTFYDLPHINKNKFYTWVQTPYSMLVQNGSLCVDTFFFMSGLLMCWGAFREMERTKGKLNIPMMY 371
            |.....|:||.....||:.:.||:.|::....||:|||:||||:...|.|.|:|||||||||:||
  Fly   302 MVLATSPNINMGYLLTWINSFYSLFVKHAVYAVDSFFFLSGLLLVVIALRSMDRTKGKLNIPLMY 366

  Fly   372 FHRYIRLTPVVAVVVLYIMSLYKYSGAGPMWFKLGTQD-KRCADTWWATLIYVQNYAFPYSICIS 435
            .|||:||||::|:.:|:.|.:.....:||:...:...| ..|..||:.||:||||||.. |:|:|
  Fly   367 LHRYLRLTPILAIAILFYMKILPLWESGPLKGSISFDDYSACESTWYWTLLYVQNYATD-SLCLS 430

  Fly   436 QSWYLAVDTQLYFLSPLFLIPLWKWGKKALVPIVIVLILCLGGTFATFMLNDFTLFRVQDDQVDL 500
            .|||||||.|||..:|..||.|:||||||...|.::::|..|..|:..::||.:|....|.
  Fly   431 HSWYLAVDMQLYIFAPFLLICLYKWGKKAAAGIFVLMLLLAGCLFSIMVINDLSLGSGGDS---- 491

  Fly   501 RQRLTYYPTHTRIPTWLIGVIFGYFLFTRNRGRQIPMSKPLVLTGWFVAFGTMLACMWGPYWRIL 565
             .|..||.|.||...:|||::|||||.| |||:...:::..||.||.:|...:.:|::..|.:
  Fly   492 -MRKLYYATQTRASPYLIGILFGYFLHT-NRGKDFKLNRLAVLLGWLIALSLIASCLFSIYGQ-- 552

  Fly   566 PDTPDSPLIEGAFFEPLSRTSWALSIGWIVWACYNGHGGLVNDFLSWGFFTGFSRLCYCMYVIHR 630
               ...|::|.||:..|:|.:|.|.:.|:|:||.:|:|||.|..||...:...|||.|..|:.|.
  Fly   553 ---NTLPIVEEAFYVSLTRIAWPLGLCWVVFACMHGYGGLANSLLSSPLWQPLSRLSYSAYIFHM 614

  Fly   631 IVQLVNAARLQTDTHFSNYDAILRWWHDFGITLTASIFATLAFEAPILGIEKAIFGKPAPKKPSP 695
            .::.:|.....|.|:||:|..:||:|.|||.|:..|....:..|||..|:|..:.  || |:|:.
  Fly   615 FIESLNGGITHTSTYFSDYQVMLRFWTDFGFTILFSYLMHILIEAPFAGLESLLL--PA-KRPNA 676

  Fly   696 GELAKAAP-VAATSASAEPEPEAKPESVVET----KTEIAPVPTN 735
            ...|...| ::...||.|..|..||...:.|    ..:.||..:|
  Fly   677 KPAAVVEPRMSEVKASVEESPVGKPAEAISTIPDEVIQAAPEKSN 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3106	NP_001285060.1	NRF	91..217	CDD:214781	33/134 (25%)
		Acyl_transf_3	286..635	CDD:280013	150/349 (43%)
		OafA	289..702	CDD:224748	172/413 (42%)
CG14219	NP_608322.1	NRF	101..211	CDD:214781	33/134 (25%)
		Acyl_transf_3	281..654	CDD:280013	164/384 (43%)
		OafA	326..683	CDD:224748	153/371 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458071
Domainoid	1	1.000	50	1.000	Domainoid score	I11639
eggNOG	1	0.900	-	-		E1_KOG3700
Homologene	1	1.000	-	-		H129774
Inparanoid	1	1.050	178	1.000	Inparanoid score	I4016
Isobase	1	0.950	-	0	Normalized mean entropy	S7984
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	1	1.000	-	-		FOG0001682
OrthoInspector	1	1.000	-	-		otm25504
orthoMCL	1	0.900	-	-		OOG6_100705
Panther	1	1.100	-	-	P	PTHR11161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X299
	13	12.750