DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg2 and PTP2

DIOPT Version :9

Sequence 1:	NP_572576.1	Gene:	Ptpmeg2 / 31907	FlyBaseID:	FBgn0028341	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_014851.3	Gene:	PTP2 / 854383	SGDID:	S000005734	Length:	750	Species:	Saccharomyces cerevisiae

Alignment Length:	413	Identity:	98/413 - (23%)
Similarity:	149/413 - (36%)	Gaps:	152/413 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   492 ENPPSSASSGFSDDDSLAGQEGDPKPIDQIVQMVKQRGRHGLIKEYADIRNRAPEGTFLHARMRA 556
            :|..||:.|..|.||::...                      |.:|     ...||.       .
Yeast   377 KNNTSSSPSPLSSDDTIMSP----------------------INDY-----ELTEGI-------Q 407

  Fly   557 NLTKNRYTDVLCYDHSRVVLAH-----------------------------EDGDEPSDYINANF 592
            :.|||||:::|.|:||||.|.|                             ....:|:||||||:
Yeast   408 SFTKNRYSNILPYEHSRVKLPHSPKPPAVSEASTTETKTDKSYPMCPVDAKNHSCKPNDYINANY 472

  Fly   593 VDGYKQKN---AYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSL 654
            :. ..|.|   .||:||.|||.|..|||::|......||:......|....|...||     ::|
Yeast   473 LK-LTQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYW-----NNL 531

  Fly   655 EFGDYHVR-----------------------------TISVEC---------------NEDYMVA 675
            .:.::.::                             .||.:|               :|.::|.
Yeast   532 SYSNHTIKLQNTWENICNINGCVLRVFQVKKTAPQNDNISQDCDLPHNGDLTSITMAVSEPFIVY 596

  Fly   676 SLELRN------------IKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGL 728
            .|:.:|            ||..:::|            .:..:..:.:..|:|...|...:....
Yeast   597 QLQYKNWLDSCGVDMNDIIKLHKVKN------------SLLFNPQSFITSLEKDVCKPDLIDDNN 649

  Fly   729 GDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLE---------DVG--TAD-IRGTVEKIR 781
            .:.........|::||||||.||||.|:|||..:|.|.         ||.  |.| |...|.::|
Yeast   650 SELHLDTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTNHSNKIDVWNMTQDLIFIIVNELR 714

  Fly   782 SQRAYSIQMPDQYVFCHLALIEY 804
            .||...:|...||:.|:.||:.|
Yeast   715 KQRISMVQNLTQYIACYEALLNY 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024
		SEC14	170..314	CDD:238099
		Y_phosphatase	557..803	CDD:278528	86/345 (25%)
		PTPc	559..803	CDD:238006	86/343 (25%)
PTP2	NP_014851.3	COG5599	344..748	CDD:227886	98/413 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2394
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.950