Protein Alignment Ptpmeg2 and PTPRS

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_002841.3
• Gene: PTPRS / 5802
• HGNCID: 9681
• Length: 1948
• Species: Homo sapiens
• Alignment Length: 354
• Identity: 135/354 - (38%)
• Similarity: 183/354 - (51%)
• Gaps: 63/354 - (17%)

  Fly   492 ENPPSSASS-----GFSDDDSLAGQEGDPKPIDQI---VQMVKQRGRHGLIKEYADIRNRAPEGT 548
            :.|.|...|     ||..:..|:   ..|.||..:   .:.:|......|.:||..| :...:.|
Human  1347 QTPDSGLRSPLREPGFHFESMLS---HPPIPIADMAEHTERLKANDSLKLSQEYESI-DPGQQFT 1407

  Fly   549 FLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTS 613
            :.|:.:..|..||||.:|:.||||||:|...:|...|||||||:||||:.:||||:||||||:|.
Human  1408 WEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETF 1472

  Fly   614 QDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYW-----------EPTEESSLEFGDYHVRTISVE 667
            .|||||:|||....|||.||:.|:.|:||.|||           :.|...::|...:.|||.|:.
Human  1473 GDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLH 1537

  Fly   668 CNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLGDTW 732
            .|             .:.|.|.|..:|||:|||:|||......|.||::|:.
Human  1538 KN-------------GSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKT------------- 1576

  Fly   733 AGHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFC 797
            ...|...|||||||||:||||.||.:|..:.|::...|.|:.|.|..:||||.|.:|..|||.|.
Human  1577 CNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1641

  Fly   798 HLALIE--------------YAYSRGMLQ 812
            |.||:|              |||.:.:.|
Human  1642 HEALLEAVGCGNTEVPARSLYAYIQKLAQ 1670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024
		SEC14	170..314	CDD:469559
		PTPc-N9	529..799	CDD:350391	117/280 (42%)
PTPRS	NP_002841.3	I-set	33..124	CDD:400151
		Ig strand B	50..54	CDD:409353
		Ig strand C	63..67	CDD:409353
		Important for binding to glycosaminoglycan chains. /evidence=ECO:0000250|UniProtKB:B0V2N1	68..72
		Ig strand E	86..93	CDD:409353
		Ig strand F	104..109	CDD:409353
		Ig strand G	117..120	CDD:409353
		IgI_2_RPTP_IIa_LAR_like	137..235	CDD:409400
		Ig strand A'	143..147	CDD:409400
		Ig strand B	150..159	CDD:409400
		Ig strand C	164..170	CDD:409400
		Ig strand C'	172..174	CDD:409400
		Ig strand D	183..187	CDD:409400
		Ig strand E	199..204	CDD:409400
		Ig strand F	213..220	CDD:409400
		Ig strand G	223..234	CDD:409400
		IgI_3_RPTP_IIa_LAR_like	248..329	CDD:409401
		Ig strand A	248..250	CDD:409401
		Ig strand A'	254..258	CDD:409401
		Ig strand B	261..269	CDD:409401
		Ig strand C	274..280	CDD:409401
		Ig strand C'	282..284	CDD:409401
		Ig strand D	287..291	CDD:409401
		Ig strand E	296..301	CDD:409401
		Ig strand F	308..315	CDD:409401
		FN3	318..>724	CDD:442628
		Ig strand G	319..328	CDD:409401
		FN3	<671..>981	CDD:442628
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	700..724
		FN3	1037..>1097	CDD:238020
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1311..1340
		R-PTPc-S-1	1370..1651	CDD:350473	125/307 (41%)
		R-PTP-S-2	1653..1942	CDD:350475	4/18 (22%)