Protein Alignment Ptpmeg2 and PTPRR

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_002840.2
• Gene: PTPRR / 5801
• HGNCID: 9680
• Length: 657
• Species: Homo sapiens
• Alignment Length: 756
• Identity: 182/756 - (24%)
• Similarity: 283/756 - (37%)
• Gaps: 208/756 - (27%)

  Fly   126 FLYARKFDIPRAVSLYEQ-----------HEQIRLKEYLYN-------IDPDVEPLRSELQTGKF 172
            |:|....||.:::.:..|           ..|:..:..:.|       .||.:..|..:.|..:.
Human    42 FIYKHSQDIEKSLDIAPQKIYRHSYHSSSEAQVSKRHQIVNSAFPRPAYDPSLNLLAMDGQDLEV 106

  Fly   173 TILPA-------------------------RTSSGAAIALFTANRHSPLSVSHTTTLQGIVYQLD 212
            ..||.                         |....||:.|.....|....:....:::..|..::
Human   107 ENLPIPAANVIVVTLQMDVNKLNITLLRIFRQGVAAALGLLPQQVHINRLIGKKNSIELFVSPIN 171

  Fly   213 ------SALQDSETQRAGLVFIYDMSGSKYSNFDYDLSQKILTLLKGGYPARLKKVLIVTAPLWF 271
                  .||...|..|:..:.:...|.|::...:....:.:   |:|.:.|         ..:|.
Human   172 RKTGISDALPSEEVLRSLNINVLHQSLSQFGITEVSPEKNV---LQGQHEA---------DKIWS 224

  Fly   272 KAPFKILRLFVREKLRERVFTVSVPQLALHVPRKALPIHLGGTLEVDHATWLLSCRQSMTNREDE 336
            |..|..:.:|:      .:|.:.|..|.:....|              ..:.||.||.....::.
Human   225 KEGFYAVVIFL------SIFVIIVTCLMILYRLK--------------ERFQLSLRQDKEKNQEI 269

  Fly   337 LLANIVGVGGGSGSGSAAGSAAIVSTNGTETEAATTAATIISAVHQLGDNNTTVVTVSNGVGPAG 401
            .|:.|                       |...|.:.|.|:.|.|..  :....|:.|.  |.|.|
Human   270 HLSPI-----------------------TLQPALSEAKTVHSMVQP--EQAPKVLNVV--VDPQG 307

  Fly   402 SASG--GATTAASAATEPNENITINGLSPSHRQAANNSSSSSSSA-------ATVANPLK----- 452
            ..:.  .||||.|....|   ..:..:....|:.:|.|.:...|:       .::..|.:
Human   308 RGAPEIKATTATSVCPSP---FKMKPIGLQERRGSNVSLTLDMSSLGNIEPFVSIPTPREKVAME 369

  Fly   453 -LNTSGSADNNSTITNATTAAGAAGAAAGTTTNGGGEFWSENPPSSASSGFSDDDSLAGQEGDPK 516
             |.::......|.:.:...::....:          || .|.|.:..               |||
Human   370 YLQSASRILTRSQLRDVVASSHLLQS----------EF-MEIPMNFV---------------DPK 408

  Fly   517 PIDQIVQMVKQRGRHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHED- 580
            .||        ..|||                          |||||..:|....|||.|..::
Human   409 EID--------IPRHG--------------------------TKNRYKTILPNPLSRVCLRPKNV 439

  Fly   581 GDEPSDYINANFVDGYKQK-NAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQ 644
            .|..|.|||||::.||..| .|:|:||||:..|..|||:|:|::...||||.|::.|:.. ||..
Human   440 TDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNE-KCVL 503

  Fly   645 YWEPTEESSLEFGDYHVRTISV-ECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAM 708
            ||  .|:..: :|...|..||| || ::|.:.:|.|:  :....::|.|:.:|||||:..|.||.
Human   504 YW--PEKRGI-YGKVEVLVISVNEC-DNYTIRNLVLK--QGSHTQHVKHYWYTSWPDHKTPDSAQ 562

  Fly   709 AMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADI 773
            .:|..:..|.|          |..|...|| |:||||||||||||.||...|...:|::.|..|.
Human   563 PLLQLMLDVEE----------DRLASQGRG-PVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDA 616

  Fly   774 RGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSRGMLQTV 814
            ...|.::|..|...:|..:||.|.|.||..|. ||...:||
Human   617 LSIVCQLRMDRGGMVQTSEQYEFVHHALCLYE-SRLSAETV 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	5/28 (18%)
		SEC14	170..314	CDD:469559	25/174 (14%)
		PTPc-N9	529..799	CDD:350391	99/272 (36%)
PTPRR	NP_002840.2	R-PTPc-R	417..642	CDD:350459	96/242 (40%)