Protein Alignment Ptpmeg2 and PTPRO

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_109592.1
• Gene: PTPRO / 5800
• HGNCID: 9678
• Length: 1216
• Species: Homo sapiens
• Alignment Length: 507
• Identity: 147/507 - (28%)
• Similarity: 225/507 - (44%)
• Gaps: 111/507 - (21%)

  Fly   358 AIVSTNGTETEAATTAATIISAV--------HQLGDNNTT-----------VVTVSNGVGPAGSA 403
            ::.:.|.|:|  :.|...:...|        .|:|.:..|           |||:|: :.||.:.
Human   728 SLFAVNKTQT--SVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTISS-LLPATAY 789

  Fly   404 SGGATT-------------AASAATEPNEN-------------------ITINGLSPSHRQAANN 436
            :...|:             .::..||.|.|                   :|:..|...|.|.|.
Human   790 NCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMAR- 853

  Fly   437 SSSSSSSAATVANPLKLNTSGSADNN---STITNATTAAGAAGAAAGTTTNGGGEFWSE------ 492
                ...|.|..|...|...|....|   |.....|.....              .|::
Human   854 ----ECGAGTFVNFASLERDGKLPYNWRRSIFAFLTLLPSC--------------LWTDYLLAFY 900

  Fly   493 -NPPSSASSGFSDDDSLAGQEGDPKPIDQIVQMVKQRGRHGLIK---EYADIRNRAPEGTFLHAR 553
             ||       :|.:.....:..:|..:|.....:|...:....|   ::.:::....:.....|.
Human   901 INP-------WSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAAD 958

  Fly   554 MRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWR 618
            :..|..|||||::|.||.|||.|...:.:|.:||||||::.||.....||:||||||:|..|||:
Human   959 LPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWK 1023

  Fly   619 MIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELRNIK 683
            |:.:|...:|||.|:..|:.||||..||..||| .:.:||..|..||.|..:|:  |....|...
Human  1024 MVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEE-PIAYGDITVEMISEEEQDDW--ACRHFRINY 1085

  Fly   684 TDEIRNVSHWQFTSWPDYGVP--SSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCS 746
            .||:::|.|:.:|:|||:|||  ::|.::|.|:..||: ||...:|            |:::|||
Human  1086 ADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQ-QATKSKG------------PMIIHCS 1137

  Fly   747 AGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCH 798
            ||:|||||||.||..:..:.|....||.|.|.::||.|...:|..:||:|.|
Human  1138 AGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIH 1189

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024
		SEC14	170..314	CDD:469559
		PTPc-N9	529..799	CDD:350391	108/275 (39%)
PTPRO	NP_109592.1	fn3	435..521	CDD:394996
		FN3	530..630	CDD:238020
		fn3	725..805	CDD:394996	15/79 (19%)
		R-PTPc-O	951..1195	CDD:350462	107/255 (42%)