DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptpmeg2 and PTPRN

DIOPT Version :10

Sequence 1:NP_572576.1 Gene:Ptpmeg2 / 31907 FlyBaseID:FBgn0028341 Length:827 Species:Drosophila melanogaster
Sequence 2:NP_002837.1 Gene:PTPRN / 5798 HGNCID:9676 Length:979 Species:Homo sapiens


Alignment Length:812 Identity:222/812 - (27%)
Similarity:326/812 - (40%) Gaps:148/812 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 ATSPSTSSSSAS----------STQNLIAVVPPQLQQ------LQVQLPAP-----------GGG 96
            |.:|:..|.:||          |..:|....|.||.|      |..:||||           |..
Human   238 AEAPALFSRTASKGIFGDHPGHSYGDLPGPSPAQLFQDSGLLYLAQELPAPSRARVPRLPEQGSS 302

  Fly    97 GGA-----GAGGGGGGGGGAAPVRRHISHTTAVKFLYA---------RKFDIPRAVSLYEQHEQI 147
            ..|     |....|.|..|..|....:....|::.|.|         |:. .|..:|......|:
Human   303 SRAEDSPEGYEKEGLGDRGEKPASPAVQPDAALQRLAAVLAGYGVELRQL-TPEQLSTLLTLLQL 366

  Fly   148 ------RLKEYLYNIDPDVEPLRSELQTGKFTI-LPARTS--SGAAIALFTANRHSPLSVSHTTT 203
                  |....:.|:..|::........|:.|. ||||||  .|...|       ||.|..    
Human   367 LPKGAGRNPGGVVNVGADIKKTMEGPVEGRDTAELPARTSPMPGHPTA-------SPTSSE---- 420

  Fly   204 LQGIVYQLDSALQDSETQRAGLVFIYDMSGSKYSNFDYDLSQKILTLLKGGYPARLKKVLIVT-- 266
                |.|:.|.: .||..:|....:..:...|.|....  ||..:.......||..:...|||  
Human   421 ----VQQVPSPV-SSEPPKAARPPVTPVLLEKKSPLGQ--SQPTVAGQPSARPAAEEYGYIVTDQ 478

  Fly   267 APLWFKAPFKILRLFVREKLRERVFTVSVPQLALHVPRKALPIHLGGTLEVDHATWLLSCRQSMT 331
            .||...|..|:|     |.|.|.|...|...:.:.|...||      |..:.|            
Human   479 KPLSLAAGVKLL-----EILAEHVHMSSGSFINISVVGPAL------TFRIRH------------ 520

  Fly   332 NREDELLANIVGVGGGSGSG-SAAGSAAIVSTNGTETEAATTAATIISAVHQLGDNNTTVVTVSN 395
            |.::..||::....|...|. .|.....|:.|...:.|.|  ||.:....|......:.::|:  
Human   521 NEQNLSLADVTQQAGLVKSELEAQTGLQILQTGVGQREEA--AAVLPQTAHSTSPMRSVLLTL-- 581

  Fly   396 GVGPAGSASGGATTAASAA------TEPNENITINGLSPSHRQAANNSSSSSSSAATVANPLKLN 454
             |..||.|  |...|.:.|      ....:...:..|.|..................:|.....|
Human   582 -VALAGVA--GLLVALAVALCVRQHARQQDKERLAALGPEGAHGDTTFEYQDLCRQHMATKSLFN 643

  Fly   455 TSGSADNNSTITNATTAAGAAGAAAGTTTNGGGEFWSENPPSSASSGFSDDDSLAGQEGDPKPID 519
            .:......|.:::.::....| |.|..:::.....|.|. |:.|:...|....:.....|     
Human   644 RAEGPPEPSRVSSVSSQFSDA-AQASPSSHSSTPSWCEE-PAQANMDISTGHMILAYMED----- 701

  Fly   520 QIVQMVKQRGRHGLIKEY-ADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDE 583
                  ..|.|..|.||: |....:|...|...|:...|:.|||:.|.|.|||:|:.|..|....
Human   702 ------HLRNRDRLAKEWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPS 760

  Fly   584 PSDYINAN-FVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWE 647
            .||||||: .::...:..|||:|||||..|..|||:|:||..|.||||.|.::|.|..:|.:|| 
Human   761 RSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYW- 824

  Fly   648 PTEESSLEFGDYHVRTIS-----VECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSA 707
            |.|.:||    |||..::     :.| ||::|.|..|:|::|.|.|.::.:.|.|||..|.|:|.
Human   825 PDEGASL----YHVYEVNLVSEHIWC-EDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPAST 884

  Fly   708 MAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRL-EDVGTA 771
            ..:|:|.:||.:           .:.|  |..||:||||.|.|||||:|.:|:.::|: :.|...
Human   885 RPLLDFRRKVNK-----------CYRG--RSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEI 936

  Fly   772 DIRGTVEKIRSQRAYSIQMPDQYVFCHLALIE 803
            ||..|:|.:|.||...::..||:.|...|:.|
Human   937 DIAATLEHVRDQRPGLVRSKDQFEFALTAVAE 968

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptpmeg2NP_572576.1 CRAL_TRIO_N <114..144 CDD:215024 6/38 (16%)
SEC14 170..314 CDD:469559 41/148 (28%)
PTPc-N9 529..799 CDD:350391 108/277 (39%)
PTPRNNP_002837.1 RESP18 homology domain 35..131
RESP18 60..160 CDD:464394
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..173
PHA03247 <234..468 CDD:223021 57/248 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 289..329 7/39 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 393..439 19/61 (31%)
Sufficient for dimerization of proICA512. /evidence=ECO:0000269|PubMed:25561468 449..575 36/152 (24%)
Receptor_IA-2 469..557 CDD:463293 26/110 (24%)
Sufficient for dimerization of proICA512. /evidence=ECO:0000250|UniProtKB:P80560 601..732 23/143 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 643..680 6/37 (16%)
R-PTP-N 693..973 CDD:350457 112/306 (37%)
Blue background indicates that the domain is not in the aligned region.

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