Protein Alignment Ptpmeg2 and PTPRM

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: XP_016881383.2
• Gene: PTPRM / 5797
• HGNCID: 9675
• Length: 1532
• Species: Homo sapiens
• Alignment Length: 951
• Identity: 228/951 - (23%)
• Similarity: 353/951 - (37%)
• Gaps: 269/951 - (28%)

  Fly    58 TATSPSTSSSSASSTQNLIAVVPPQLQ-QLQVQLPAPGGGGGAGAGGGGGGGGGAAPVRRHISHT 121
            ||:..........||...|..:.|..: ::.|.|..||       .||.|..|.|...|.    .
Human   347 TASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPG-------EGGTGSPGPALRTRT----K 400

  Fly   122 TAVKFLYARKFDIPRAVSLYEQHEQIRLKEYLYNID---------------PDVEPLRSELQTG- 170
            .|......||.::   |.:..:...||.:.:.||:.               ...|.:|.|:...
Human   401 CADPMRGPRKLEV---VEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDT 462

  Fly   171 -----KFTILPARTSSGAAIALFTANRHS---------------PLSVSHTTTLQGIVYQLDSAL 215
                 :.||......:..::.|...|...               |.:|. |.::||..::....|
Human   463 ENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVP-TESIQGSTFEEKIFL 526

  Fly   216 QDSE-TQRAGLVFIYDMSGSKYSNFD--YDLSQKI----------------------------LT 249
            |..| ||..|::.:|:::....|:||  .|||.:.                            .:
Human   527 QWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRAS 591

  Fly   250 LLKG-GYPARLKKVLIVTAP-------------------LWFK------APFKILRLFVREKLRE 288
            ..|| |.||..:....::||                   :..|      ||..:.::.|.|:...
Human   592 TAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERPR 656

  Fly   289 RV---------------------------FTVSVPQLALH---------------------VPRK 305
            |.                           |....|..:|.                     :|.|
Human   657 RTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYK 721

  Fly   306 ALPIHLGGTLEVDHATWLLSCRQSMTNRE---DELLANIVGVGGGSGSGSAAGSAA-------IV 360
            :..|:.......:..| .:.|.|..|...   .:|....:.:...:|.|...|:|.       ..
Human   722 SYRIYFQAASRANGET-KIDCVQVATKAAIIVTQLTTPYIRIAPAAGDGQLTGAATPKPVPEPEK 785

  Fly   361 STNGTETEAATTAATIISAVHQLGDNNTTVVTVSNGVGPAGSASGGATTAASAATEPNENITING 425
            .|:.|...|...|..::..:..||     ||.|   :.....|.....|.:|  |.....:.:|.
Human   786 QTDHTVKIAGVIAGILLFVIIFLG-----VVLV---MKKRKLAKKRKETMSS--TRQEMTVMVNS 840

  Fly   426 LSPSHRQAANNSSSSSS-------SAATVANP----LKLNTSGSADNNS-------------TIT 466
            :..|:.:...|...:.|       :..:|::|    :|.||..::..||             .|.
Human   841 MDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDPFVPTAILVPIN 905

  Fly   467 NATTAAGAAGAAAGTTTNGGGEFWSENPPSSASSGFSDDDSLAGQEGDPKP-------IDQIVQM 524
            :.|..     .|:.|::......:.:..|:          .:..|.|...|       :..|.||
Human   906 DETHT-----MASDTSSLVQSHTYKKREPA----------DVPYQTGQLHPAIRVADLLQHITQM 955

  Fly   525 VKQRGRHGLIKEYADI--RNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDY 587
            ....| :|..:||...  ...||..:   |:...|..||||.:::.||||||.|...:||..|||
Human   956 KCAEG-YGFKEEYESFFEGQSAPWDS---AKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDY 1016

  Fly   588 INANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYW-EPTE- 650
            ||.|::|||.:.|.||:||||:.:|..|||||:|.::...|:|.|.::|.|||||.:|| :.||
Human  1017 INGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEI 1081

  Fly   651 ---------ESSLEFGDYHVRTISVE---------CNEDYMVASLELRNIKTDEIRNVSHWQFTS 697
                     |:.| ..:|.:||.:||         |:     .|.|:......|||.:..:.||.
Human  1082 YKDIKVTLIETEL-LAEYVIRTFAVEKGGAGGEANCS-----PSREVSQRGVHEIREIRQFHFTG 1140

  Fly   698 WPDYGVPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICI 762
            |||:|||..|..:|.|:::|:.|..             |...|:|||||||.||||.||.:||.:
Human  1141 WPDHGVPYHATGLLGFVRQVKSKSP-------------PSAGPLVVHCSAGAGRTGCFIVIDIML 1192

  Fly   763 SRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIE 803
            ...|..|..||...|.::||:|...:|..:||||.|.|::|
Human  1193 DMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE 1233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	5/29 (17%)
		SEC14	170..314	CDD:469559	41/269 (15%)
		PTPc-N9	529..799	CDD:350391	113/291 (39%)
PTPRM	XP_016881383.2	MAM	50..207	CDD:214533
		FN3	180..>663	CDD:442628	62/330 (19%)
		ig	217..299	CDD:395002
		fn3	524..599	CDD:394996	16/74 (22%)
		R-PTPc-M-1	947..1236	CDD:350481	119/310 (38%)
		R-PTPc-M-2	1322..1527	CDD:350483