Protein Alignment Ptpmeg2 and PTPRH

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: XP_016882545.1
• Gene: PTPRH / 5794
• HGNCID: 9672
• Length: 1137
• Species: Homo sapiens
• Alignment Length: 835
• Identity: 204/835 - (24%)
• Similarity: 319/835 - (38%)
• Gaps: 208/835 - (24%)

  Fly    51 GANCS-----TTTATSPSTSSSSASSTQNLIAV---VP--PQLQQLQVQLPAPGGGGGAGAGGGG 105
            |.|.|     .|||.:|..:....:.|.:.||:   ||  |..|.....:...|.|||...
Human   394 GINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTET---- 454

  Fly   106 GGGGGAAPVRRHISHTTAVKFLYARKFDIPRAVSLYEQHEQIRLKEYLYNIDPDVEPLRSELQTG 170
                      |:.::|:...                |:.|...|  |.:::..:....|...|..
Human   455 ----------RNTTNTSVTA----------------ERLEPGTL--YTFSVWAEKNGARGSRQNV 491

  Fly   171 KFTILPARTSS-------GAAIALFTANRHSPLSVSHTTTLQGIVYQLDSALQDSETQ-RAGL-V 226
            ..:.:|...:|       .:.|||.......|...|::..:..:    ...:.|..|| .:|. :
Human   492 SISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWV----REGMTDPRTQSTSGTDI 552

  Fly   227 FIYDM-SGSKYSNFDYDLSQKILTLLK-----GGYPARLKKVLIVTAP----------------- 268
            .:.:: :||.|.          ||:..     .||.:.|   ...|||
Human   553 TLKELEAGSLYH----------LTVWAERNEVRGYNSTL---TAATAPNEVTDLQNETQTKNSVM 604

  Fly   269 LWFKAPFKILRLFVREKLRERVFTVSVPQLALHV----------PRKALPIHLGGTLEVDHATWL 323
            ||:|||                   ..|...|:|          ||:.         :...|.|:
Human   605 LWWKAP-------------------GDPHSQLYVYWVQWASKGHPRRG---------QDPQANWV 641

  Fly   324 LSCRQSMTNREDELLANIVGVGGGSGSGSAAGSAAIVSTNGTETEAATTAATIISAVHQLGDNNT 388
                 :.|:|.:|....:..:..|:.......:......:.|::..|:|....::.        |
Human   642 -----NQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTI--------T 693

  Fly   389 TVVTVSNGVG-------PAGSASG-----GATTAASAATEPNENITINGLSPSHRQAANNSSSSS 441
            :.|:.|.|.|       |.|....     |....:...:...|.:::.||.|:.        |..
Human   694 SCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVLGLGPAR--------SYP 750

  Fly   442 SSAATVANPLKLNTSGSADNNSTITNATTAAGAAGAAAG----TTTNGGGEFW-------SENPP 495
            ::..|:.:.:|:      .::|.:.:..:|...|||..|    ....|...|:       .:..|
Human   751 ATITTIWDGMKV------VSHSVVCHTESAGVIAGAFVGILLFLILVGLLIFFLKRRNKKKQQKP 809

  Fly   496 SSASSGFSDDDSLAGQEGDPKPIDQIVQMVKQRGRH---GLIKEYADIRNRAPEGTFLHARMRAN 557
            ......||....:        |.:.....|::..|.   |...||..:.......:.:.|....|
Human   810 ELRDLVFSSPGDI--------PAEDFADHVRKNERDSNCGFADEYQQLSLVGHSQSQMVASASEN 866

  Fly   558 LTKNRYTDVLCYDHSRVVL--AHEDGDEP-SDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRM 619
            ..||||.:||.||.|||.|  .||   || ||||||:|:.|......:|:||||||:|..||||:
Human   867 NAKNRYRNVLPYDWSRVPLKPIHE---EPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRL 928

  Fly   620 IWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELRNIKT 684
            :|||....:||.|..||.|||||..|| |.:......|...|..:..|..|::.|..|.|..::.
Human   929 VWEQQSHTLVMLTNCMEAGRVKCEHYW-PLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEE 992

  Fly   685 DEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGI 749
            .:..:|..:.:.:|||:|||||...:|.|.:.:|:...|.::|          |||| ||||||:
Human   993 QKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEG----------GPPI-VHCSAGV 1046

  Fly   750 GRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEY 804
            |||||.|.||:.:.:|:..|.......|.|:|..|...:|...||||.|..::.:
Human  1047 GRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRF 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	3/29 (10%)
		SEC14	170..314	CDD:469559	32/185 (17%)
		PTPc-N9	529..799	CDD:350391	108/275 (39%)
PTPRH	XP_016882545.1	FN3	52..139	CDD:238020
		FN3	141..228	CDD:238020
		FN3	231..314	CDD:238020
		FN3	285..>709	CDD:442628	72/404 (18%)
		R-PTPc-H	870..1102	CDD:350467	102/247 (41%)