Protein Alignment Ptpmeg2 and PTPRF

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: XP_005271136.1
• Gene: PTPRF / 5792
• HGNCID: 9670
• Length: 1922
• Species: Homo sapiens
• Alignment Length: 326
• Identity: 128/326 - (39%)
• Similarity: 182/326 - (55%)
• Gaps: 45/326 - (13%)

  Fly   495 PSSASSGFSDDDSLAGQEGDPKPIDQIVQMVKQ-RGRHGL--IKEYADIRNRAPEGTFLHARMRA 556
            |.|:.....:..|:  ::..|.||..:...::: :...||  .:||..| :...:.|:.::.:..
Human  1328 PGSSVPSCPNTSSM--RDHPPIPITDLADNIERLKANDGLKFSQEYESI-DPGQQFTWENSNLEV 1389

  Fly   557 NLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIW 621
            |..||||.:|:.||||||:|...||...|||||||::|||:::||||:||||||:|..|||||:|
Human  1390 NKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVW 1454

  Fly   622 EQHCLVIVMTTRVMERGRVKCGQYW-----------EPTEESSLEFGDYHVRTISVECNEDYMVA 675
            ||....:||.||:.|:.||||.|||           :.|...::|...|.|||.:
Human  1455 EQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFA---------- 1509

  Fly   676 SLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHP-RGP 739
               |....:.|.|.:..:||.:|||:|||.....:|.||::|:              |.:| ...
Human  1510 ---LHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVK--------------ACNPLDAG 1557

  Fly   740 PIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEY 804
            |:|||||||:||||.||.:|..:.|::...|.||.|.|..:||||.|.:|..|||||.|.||:|.
Human  1558 PMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA 1622

  Fly   805 A 805
            |
Human  1623 A 1623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024
		SEC14	170..314	CDD:469559
		PTPc-N9	529..799	CDD:350391	117/283 (41%)
PTPRF	XP_005271136.1	I-set	33..124	CDD:400151
		Ig strand B	50..54	CDD:409353
		Ig strand C	63..67	CDD:409353
		Ig strand E	86..93	CDD:409353
		Ig strand F	104..109	CDD:409353
		Ig strand G	117..120	CDD:409353
		IgI_2_RPTP_IIa_LAR_like	136..226	CDD:409400
		Ig strand A	136..138	CDD:409400
		Ig strand A'	143..147	CDD:409400
		Ig strand B	150..159	CDD:409400
		Ig strand C	164..170	CDD:409400
		Ig strand C'	172..174	CDD:409400
		Ig strand D	183..187	CDD:409400
		Ig strand E	190..195	CDD:409400
		Ig strand F	204..211	CDD:409400
		Ig strand G	214..225	CDD:409400
		IgI_3_RPTP_IIa_LAR_like	239..320	CDD:409401
		Ig strand A	239..241	CDD:409401
		Ig strand A'	245..249	CDD:409401
		Ig strand B	252..260	CDD:409401
		Ig strand C	265..271	CDD:409401
		Ig strand C'	273..275	CDD:409401
		Ig strand D	278..282	CDD:409401
		Ig strand E	287..292	CDD:409401
		Ig strand F	299..306	CDD:409401
		Ig strand G	310..319	CDD:409401
		FN3	<311..716	CDD:442628
		FN3	714..820	CDD:238020
		FN3	825..914	CDD:238020
		FN3	923..1011	CDD:238020
		FN3	1020..>1079	CDD:238020
		R-PTPc-F-1	1350..1625	CDD:350474	122/302 (40%)
		R-PTP-F-2	1627..1917	CDD:350477