Protein Alignment Ptpmeg2 and PTPRD

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_001364887.1
• Gene: PTPRD / 5789
• HGNCID: 9668
• Length: 1932
• Species: Homo sapiens
• Alignment Length: 349
• Identity: 131/349 - (37%)
• Similarity: 186/349 - (53%)
• Gaps: 60/349 - (17%)

  Fly   495 PSSASSGFSDD---DSLAGQEGDPKPIDQI---VQMVKQRGRHGLIKEYADIRNRAPEGTFLHAR 553
            |.|..||:..:   .|:|..  .|.||.::   ::.:|........:||..| :...:.|:.|:.
Human  1335 PGSDDSGYPGNLHSSSMASH--PPIPILELADHIERLKANDNLKFSQEYESI-DPGQQFTWEHSN 1396

  Fly   554 MRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWR 618
            :..|..||||.:|:.||||||:|:..:|...|||:|||::|||:::||||:|||.||:|..||||
Human  1397 LEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWR 1461

  Fly   619 MIWEQHCLVIVMTTRVMERGRVKCGQYW-----------EPTEESSLEFGDYHVRTISVECNEDY 672
            |||||....:||.|::.||.||||.|||           :.|...::|...|.|||.::..|
Human  1462 MIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKN--- 1523

  Fly   673 MVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPR 737
                      .:.|.|.|..:|||:|||:|||......|.||::|:.             ...|.
Human  1524 ----------GSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKT-------------CNPPD 1565

  Fly   738 GPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALI 802
            ..|:|||||||:||||.||.:|..:.|::...|.||.|.|..:|:||.|.:|..|||:|.|.||:
Human  1566 AGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL 1630

  Fly   803 E--------------YAYSRGMLQ 812
            |              |||.:.:.|
Human  1631 EAVTCGNTEVPARNLYAYIQKLTQ 1654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024
		SEC14	170..314	CDD:469559
		PTPc-N9	529..799	CDD:350391	113/280 (40%)
PTPRD	NP_001364887.1	I-set	24..115	CDD:400151
		Ig strand B	41..45	CDD:409390
		Ig strand C	54..58	CDD:409390
		Ig strand E	77..84	CDD:409390
		Ig strand F	95..100	CDD:409390
		Ig strand G	108..111	CDD:409390
		IgI_2_RPTP_IIa_LAR_like	127..226	CDD:409400
		Ig strand A	127..129	CDD:409400
		Ig strand A'	134..138	CDD:409400
		Ig strand B	141..150	CDD:409400
		Ig strand C	155..161	CDD:409400
		Ig strand C'	163..165	CDD:409400
		Ig strand D	174..178	CDD:409400
		Interaction with IL1RAPL1. /evidence=ECO:0000250	180..189
		Mini-exon peptide A9, sufficient for interaction with IL1RAPL1. /evidence=ECO:0000250|UniProtKB:Q64487	181..189
		Ig strand E	190..195	CDD:409400
		Ig strand F	204..211	CDD:409400
		Ig strand G	214..225	CDD:409400
		Mini-exon peptide B, required for interaction with SLITRK2 and in the function in pre-synaptic differentiation, Acts as an adjustable linker to control relative positions and orientations of the PTPRD second and third immunoglobilin domains for their simultaneous interactions with the first immunoglobilin domain of IL1RAPL1 and IL1RAP, Modulates affinity for IL1RAPL1 and IL1RAP. /evidence=ECO:0000250|UniProtKB:Q64487	227..230
		IgI_3_RPTP_IIa_LAR_like	239..320	CDD:409401
		Ig strand A	239..241	CDD:409401
		Ig strand A'	245..249	CDD:409401
		Ig strand B	252..260	CDD:409401
		Ig strand C	265..271	CDD:409401
		Ig strand C'	273..275	CDD:409401
		Ig strand D	278..282	CDD:409401
		Ig strand E	287..292	CDD:409401
		Ig strand F	299..306	CDD:409401
		FN3	304..>736	CDD:442628
		Ig strand G	310..319	CDD:409401
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	603..623
		fn3	713..812	CDD:394996
		FN3	<789..1127	CDD:442628
		FN3	922..1013	CDD:238020
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1304..1324
		R-PTPc-D-1	1354..1637	CDD:350472	121/311 (39%)
		R-PTP-D-2	1638..1929	CDD:350476	4/17 (24%)