Protein Alignment Ptpmeg2 and PTPN13

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: XP_011530467.1
• Gene: PTPN13 / 5783
• HGNCID: 9646
• Length: 2507
• Species: Homo sapiens
• Alignment Length: 928
• Identity: 222/928 - (23%)
• Similarity: 358/928 - (38%)
• Gaps: 228/928 - (24%)

  Fly    55 STTTATSPSTSSSSASSTQNLIAVVPPQLQQLQVQLPAPGGGGG-AGAGGGGGGGGGAAPVRRHI 118
            |:..::.||....|.||.:|.::      .:.:.|..:|..... :.:.|.|......||.  :|
Human  1619 SSKDSSQPSCVEQSTSSDENEMS------DKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPA--NI 1675

  Fly   119 SHTTAVKFLYARKFDIPRAVSLYEQHEQIRLKE---------YLYNI-------DPDVEPLRSEL 167
            |::|....|:.   .:...||..:.|.:....:         |...|       |.:..||..::
Human  1676 SNSTWSSALHQ---TLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDM 1737

  Fly   168 QTGKFTILPARTSSGAAIALFTANRHS-PLSVSHTTTLQGIVYQLDSALQDSE-----------T 220
            ..|:.....:.::|.:::..:..:..| |....:.|.|:.   .|::.|:|.|           :
Human  1738 APGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKN---DLENHLEDFELEVELLITLIKS 1799

  Fly   221 QRAGLVFIYDMSGSKYSNFDYDLSQ---KILTLLKGGYPARLKKV--LIVT------APLWFKAP 274
            ::..|.|.......:...:.:|:.|   |....||.|  .||.||  ..||      |....:|.
Human  1800 EKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPG--DRLIKVNDTDVTNMTHTDAVNLLRAA 1862

  Fly   275 FKILRLFVREKL---RERVFTVSVPQLALHVPRKALPIHL-GGTLEVDHATWLLSCR-QSMTNRE 334
            .|.:||.:...|   |..:....:|.:.|...::.|...| ||...:....::.... :|:...|
Human  1863 SKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIE 1927

  Fly   335 DEL-LANIVGVGGGSGSGSAAGSAAIVSTNGTETEAATTA--ATIISAVHQLGDNNTTVV----- 391
            ..| |.:::....|            |||.|...|....|  .::.|.|.:...|:..||
Human  1928 GNLQLLDVIHYVNG------------VSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKR 1980

  Fly   392 --------TVSNGVGPAGSASGGATT-----AASAATEPNE-----------------NITI-NG 425
                    |..||....||.|..|.|     :..|..|.||                 |:|: .|
Human  1981 SAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKG 2045

  Fly   426 LSP----SHRQAANNSSS--------SSSSAATVANPLKLNTSGSADNNSTITNATTAAG-AAGA 477
            ..|    ::.:..|||.|        ..|..|.|...|.......|.|   :.|...||| :.|.
Human  2046 SFPNQSSNYSKCPNNSESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQN---LLNENNAAGYSCGP 2107

  Fly   478 AA----------------------------GTTTNGGGEFWSENPPSSA-----SSGFSDDDSL- 508
            ..                            .|..||..|:..|...|.:     ....:|||.:
Human  2108 GTLKMNGKLSEERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEIT 2172

  Fly   509 ----------AGQEGDPK-------------PIDQIVQMVKQRGRH---------GLI------K 535
                      ...|...|             |:.:::...|..|.:         ||:      |
Human  2173 WGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSK 2237

  Fly   536 EYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVD---GYK 597
            |..:::...|....|..:.:.|..||||.::|.||.:||.|..|.|     ||||:|:.   | |
Human  2238 ELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGG-----YINASFIKIPVG-K 2296

  Fly   598 QKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPT--EESSLEFGDYH 660
            ::..||:.|||||.|..|||:|||||...||.|.|:.:|..::||.:|| |.  .::::......
Human  2297 EEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYW-PNILGKTTMVSNRLR 2360

  Fly   661 VRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLV 725
            :..:.::..:.::|.::.|.:|:|.|:|::||..||:|||:..||....:|.|:..:|...
Human  2361 LALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH---- 2421

  Fly   726 QGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQM 790
                       |..||:.||||||||:||.|.:|:.:..:......||...|..:|.||...:|.
Human  2422 -----------RSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQT 2475

  Fly   791 PDQYVFCHLALIEYAYSR 808
            .|||:||:..:: |..:|
Human  2476 EDQYIFCYQVIL-YVLTR 2492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	6/29 (21%)
		SEC14	170..314	CDD:469559	36/170 (21%)
		PTPc-N9	529..799	CDD:350391	98/289 (34%)
PTPN13	XP_011530467.1	KIND	3..190	CDD:214801
		FERM_F1_PTPN13	571..666	CDD:340715
		B41	573..781	CDD:214604
		PH-like	777..877	CDD:473070
		PDZ1_PTPN13-like	1090..1181	CDD:467285
		PTN13_u3	1177..1367	CDD:465189
		PDZ2-PTPN13_FRMPD2-like	1365..1456	CDD:467254
		PDZ3_PTPN13_FRMPD2-like	1504..1593	CDD:467181
		PDZ4_PTPN13-like	1789..1873	CDD:467182	19/85 (22%)
		PDZ5_PTPN13-like	1884..1970	CDD:467183	19/97 (20%)
		PTPc-N13	2257..2490	CDD:350445	92/255 (36%)