Protein Alignment Ptpmeg2 and PTPN4

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_002821.1
• Gene: PTPN4 / 5775
• HGNCID: 9656
• Length: 926
• Species: Homo sapiens
• Alignment Length: 906
• Identity: 218/906 - (24%)
• Similarity: 336/906 - (37%)
• Gaps: 283/906 - (31%)

  Fly   113 PVRRHISHTTAVKFLYARKFDIPRAVSLYEQHEQIRLKEYLYNIDPDVEPLRSELQTGKFTILPA 177
            |:|:.:...:.....:..||.:.....|.|::.:     |.|.:.     ::.::.||:   ||.
Human    90 PIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTR-----YQYFLQ-----IKQDILTGR---LPC 141

  Fly   178 RTSSGAAIALFTANRHSPL-SVSHTTTLQGIVYQLDSAL-----QDSETQRAGL----------- 225
            .:::.|.:|.|..  .|.| ....:..|.|  |..|.:.     ||.|.:.|.|
Human   142 PSNTAALLASFAV--QSELGDYDQSENLSG--YLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAE 202

  Fly   226 -VFIY-------DMSGSKYSNFDYDLSQK--ILTLLKGGYPARLKKVLIVTAPLWF---KAPFKI 277
             .|.|       ::.|.:: ::..|.|..  ::.::.||......:|.:.|.| |.   |..||.
Human   203 AEFNYLNTARTLELYGVEF-HYARDQSNNEIMIGVMSGGILIYKNRVRMNTFP-WLKIVKISFKC 265

  Fly   278 LRLFVREKLRERVFTVSVPQLALHVPRKALPIHLGGTLE------------VDHATWLLSCR--- 327
            .:.|:  :||:.          ||..|:.|   ||..:.            |:|.|:....|
Human   266 KQFFI--QLRKE----------LHESRETL---LGFNMVNYRACKNLWKACVEHHTFFRLDRPLP 315

  Fly   328 ------------------------QSMTNREDELLANIVGVGGGSGSGSAAGSA---AIVSTNG- 364
                                    ||:...:::  ||...|...|.|...|...   .:||.|.
Human   316 PQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEK--ANKDRVFARSPSKPLARKLMDWEVVSRNSI 378

  Fly   365 ----TETEAATTAATIISAVHQLGDNNTTVVTVSNGVGPAGSASGGATTAASAATEPNENITING 425
                .||::..:.:...:..|:    |:|.......:.|   :|.|........|.|:| :.:|.
Human   379 SDDRLETQSLPSRSPPGTPNHR----NSTFTQEGTRLRP---SSVGHLVDHMVHTSPSE-VFVNQ 435

  Fly   426 LSPSHRQAANNSSSSSSSAAT-----------------------------------------VAN 449
            .|||..||.:....||.|..|                                         .::
Human   436 RSPSSTQANSIVLESSPSQETPGDGKPPALPPKQSKKNSWNQIHYSHSQQDLESHINETFDIPSS 500

  Fly   450 PLK--------------------------LNTSGSADNNSTITNATTAAGAAGAAAGTTTNGG-- 486
            |.|                          .|..|..|....:..:..|.|..........|.|
Human   501 PEKPTPNGGIPHDNLVLIRMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCVPRLNEGDQ 565

  Fly   487 -----------------------------GEFW---------------SENPP--------SSAS 499
                                         ||..               .||.|        :...
Human   566 VVLINGRDIAEHTHDQVVLFIKASCERHSGELMLLVRPNAVYDVVEEKLENEPDFQYIPEKAPLD 630

  Fly   500 SGFSDDDSLAGQEGDPKPIDQIVQMVKQRGRHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYT 564
            |...||.||.         :.::|:.:......::.::..:..:.|..|...|::..|::||||.
Human   631 SVHQDDHSLR---------ESMIQLAEGLITGTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYR 686

  Fly   565 DVLCYDHSRVVLAHEDGDEPSDYINANFVD----GYKQKNAYISTQGPLPKTSQDFWRMIWEQHC 625
            |:..||.:||:|   .|:|  ||||||:::    .....|.||:.|||||.|..|||:|.|||..
Human   687 DISPYDATRVIL---KGNE--DYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGS 746

  Fly   626 LVIVMTTRVMERGRVKCGQYW-EPTEESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRN 689
            .::||.|..:|||||||.||| |||..||  :|.|.|...|.|.|..|:...:.|.|.:.:|.|.
Human   747 SMVVMLTTQVERGRVKCHQYWPEPTGSSS--YGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRP 809

  Fly   690 VSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGT 754
            ::..|:.:|||:|||..:...|:|:..||.|:|             .:..|:||||||||||||.
Human   810 LTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRA-------------GKEEPVVVHCSAGIGRTGV 861

  Fly   755 FITLDICISRLE---DVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSRGMLQ 812
            .||::..:..:|   .|...||   |..:|.|||..||.|.||.|...|::: .|..|.::
Human   862 LITMETAMCLIECNQPVYPLDI---VRTMRDQRAMMIQTPSQYRFVCEAILK-VYEEGFVK 918

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	5/29 (17%)
		SEC14	170..314	CDD:469559	40/173 (23%)
		PTPc-N9	529..799	CDD:350391	110/277 (40%)
PTPN4	NP_002821.1	B41	30..222	CDD:214604	29/149 (19%)
		FERM_C_PTPN4_PTPN3_like	216..310	CDD:270010	24/110 (22%)
		FA	324..365	CDD:462582	7/42 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	380..412		5/35 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	430..475		11/45 (24%)
		PDZ_PTPN3-4-like	513..602	CDD:467190	9/88 (10%)
		PTP_DSP_cys	641..914	CDD:475123	113/296 (38%)