Protein Alignment Ptpmeg2 and PTPN3

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: XP_011517190.1
• Gene: PTPN3 / 5774
• HGNCID: 9655
• Length: 934
• Species: Homo sapiens
• Alignment Length: 874
• Identity: 204/874 - (23%)
• Similarity: 326/874 - (37%)
• Gaps: 259/874 - (29%)

  Fly   131 KFDIPRAVSLYEQHEQIRLKEYLYNIDPDVEPLRSELQTGKFTILPARTSSGAAIALFTANRH-- 193
            :|.||...:|  |.||.|   :||.:.     |:.::..|:.|   ...:|...:|.:....|
Human   129 RFFIPDPNTL--QQEQTR---HLYFLQ-----LKMDICEGRLT---CPLNSAVVLASYAVQSHFG 180

  Fly   194 ---------SPLSVSH---------TTTLQGIVYQLDSALQDSETQR-----AGLVFIYDM---S 232
                     ..||.||         .|.::.: ::..|.|:.||.:.     |..:..|.:   |
Human   181 DYNSSIHHPGYLSDSHFIPDQNEDFLTKVESL-HEQHSGLKQSEAESCYINIARTLDFYGVELHS 244

  Fly   233 GSKYSNFDYDLSQKILTLLKGGYPARLKKVLIVTAPLW---FKAPFKILRLFVREK-----LRER 289
            |....|.|.     ::.:...|. |..:|.:..:...|   .|..||..:.|:.::     .||.
Human   245 GRDLHNLDL-----MIGIASAGV-AVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREH 303

  Fly   290 VFTVS--------------VPQLALHVPRKALPIHLGGTLEVDHATWLLSCRQSMTNREDELLAN 340
            :...:              |........:|.||    ....|....|.:..|.:..:..::....
Human   304 IVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLP----QEKNVLSQYWTMGSRNTKKSVNNQYCKK 364

  Fly   341 IVGVGGGSGSGSAAGSAAIVSTNGTETEAATTAATIIS--------------AVHQLGD---NNT 388
            ::|     |..........:|....||::..:.:..|:              ..|...|   |..
Human   365 VIG-----GMVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEM 424

  Fly   389 TVVTVSNGV--------GPAGSASGGATTAASAATEPN-ENITINGLSPSHRQAANNSSSSSSSA 444
            |.:|.:..|        .|..|.|     ..|....|: |:::.|..:.|:....::||.|.||
Human   425 TYITETEDVFYTYKGSLAPQDSDS-----EVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSS- 483

  Fly   445 ATVANPLKLNTSGSA----------DNNSTITNATTAAGAAGAAAGTTTNG-------------G 486
                     |..||.          |:...:|...:...|:........||             .
Human   484 ---------NAPGSCSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDED 539

  Fly   487 GEFW-------------------SENPPSSASSGFSDDDSLA---GQEGDPKPIDQIVQMVK-QR 528
            |:|.                   .|:|..:.....::.|.:.   |::......||:|..:| .|
Human   540 GKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASR 604

  Fly   529 GRHG----------LIKEYADIRNR--------------APEG---------------------- 547
            ..|.          .::.:||.::.              .|||
Human   605 ESHSRELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLI 669

  Fly   548 --------------TFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVD---- 594
                          ||  |::..||.||||.|||.||.:||:|   .|:|  |||||::|:
Human   670 QFEQLYRKKPGLAITF--AKLPQNLDKNRYKDVLPYDTTRVLL---QGNE--DYINASYVNMEIP 727

  Fly   595 GYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDY 659
            .....|.||:||||||.|...||:::|:|...:|||.|.:.||||.||.||| |.....:..|.:
Human   728 AANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYW-PDPPDVMNHGGF 791

  Fly   660 HVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQL 724
            |::..|.:|...|:...:.:.|.:|.|...|:|.|:.:|||:|||..:...|.|:..||..:..
Human   792 HIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVD- 855

  Fly   725 VQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLD--ICIS-RLEDVGTADIRGTVEKIRSQRAY 786
                         ..|::|||||||||||..:|::  :|:: |...:...||   |.|:|.|||.
Human   856 -------------SEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDI---VRKMRDQRAM 904

  Fly   787 SIQMPDQYVFCHLALIEYAYSRGMLQTVD 815
            .:|...||.|...|::. .|..|::|.:|
Human   905 MVQTSSQYKFVCEAILR-VYEEGLVQMLD 932

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	4/12 (33%)
		SEC14	170..314	CDD:469559	34/193 (18%)
		PTPc-N9	529..799	CDD:350391	107/336 (32%)
PTPN3	XP_011517190.1	B41	52..243	CDD:214604	27/127 (21%)
		FERM_C_PTPN4_PTPN3_like	237..330	CDD:270010	16/98 (16%)
		PDZ_PTPN3-4-like	527..616	CDD:467190	12/88 (14%)
		PTPc-N3	652..925	CDD:350448	103/298 (35%)