Protein Alignment Ptpmeg2 and PTPN1

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_002818.1
• Gene: PTPN1 / 5770
• HGNCID: 9642
• Length: 435
• Species: Homo sapiens
• Alignment Length: 274
• Identity: 115/274 - (41%)
• Similarity: 157/274 - (57%)
• Gaps: 20/274 - (7%)

  Fly   537 YADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNA 601
            |.|||:.|.:.....|::..|..:|||.||..:||||:.|..||    :|||||:.:...:.:.:
Human    20 YQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQED----NDYINASLIKMEEAQRS 80

  Fly   602 YISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVR--TI 664
            ||.||||||.|...||.|:|||....:||..||||:|.:||.|||...||..:.|.|.:::  .|
Human    81 YILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLI 145

  Fly   665 SVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLG 729
            |.:....|.|..|||.|:.|.|.|.:.|:.:|:|||:|||.|..:.||||.||||..:.
Human   146 SEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSL------ 204

  Fly   730 DTWAGHPRGPPIVVHCSAGIGRTGTFITLDICI---SRLEDVGTADIRGTVEKIRSQRAYSIQMP 791
                 .|...|:||||||||||:|||...|.|:   .:.:|..:.||:..:.::|..|...||..
Human   205 -----SPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTA 264

  Fly   792 DQYVFCHLALIEYA 805
            ||..|.:||:||.|
Human   265 DQLRFSYLAVIEGA 278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024
		SEC14	170..314	CDD:469559
		PTPc-N9	529..799	CDD:350391	110/266 (41%)
PTPN1	NP_002818.1	PTPc-N1	16..292	CDD:350456	115/274 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	338..359
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	378..398