Protein Alignment Ptpmeg2 and ptprja

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_001129714.1
• Gene: ptprja / 559679
• ZFINID: ZDB-GENE-030131-8301
• Length: 1650
• Species: Danio rerio
• Alignment Length: 1023
• Identity: 246/1023 - (24%)
• Similarity: 363/1023 - (35%)
• Gaps: 299/1023 - (29%)

  Fly    15 NNNSGSRSEQDSGCHRRLFLCI-----AKAVKQFIDLC------NNLGA---NCST--------- 56
            |||:....:..|.....:.:..     .|:..|||..|      ||:.:   |.||
Zfish   664 NNNTVKLEQLQSASQYNISIIALTPGGTKSDPQFITACSRPNRVNNVSSVALNVSTVRLSWARPL 728

  Fly    57 ---------TTATSPSTSSSSASSTQNLIAVV---PPQLQQLQVQLPAPGGGGGAGAGGGGGGGG 109
                     ...::.:.:|.:.|::..:|.|.   |..|.|:.:...|.|..|
Zfish   729 QYNQLVSYQVLVSNCTKNSMNMSTSTEMITVTNLQPGTLCQISIYSVACGLLG------------ 781

  Fly   110 GAAPVRRHISHTTAVKFLYARKFDIPRAVSLYEQHEQIRLKEYLYNID----PDVEPLRSELQTG 170
              .||...:....:.............::.:...|....|..|:.||.    .|...|.|.....
Zfish   782 --QPVNTSVLTMPSTVQPVVNSQGSNNSLLVLWSHPDGGLDMYILNISSDGWSDFSFLNSTENNY 844

  Fly   171 KFTILPART---------------SSGAAIALFTANRHSPLSVSHTTTLQGIVYQLDSALQDSET 220
            .||.|.|.|               :|||.::....|....::|....| ..::...|.|    :.
Zfish   845 TFTQLKAATLYTVTLTTVKGSFQETSGAVVSATYPNSPGMITVLFKNT-HSVLLHWDIA----QN 904

  Fly   221 QRAGLVFIYDMS-GSKYSNFDYDLSQKILTL--LKGGYPARLKKVLIVTAPLWFKA--------- 273
            ...| .|.|.:| .|..:|..|......|.|  |:.|.|..:.  |....||..::
Zfish   905 MTPG-SFNYSLSFWSSKNNSLYLTPNNTLLLDGLQSGTPYNVS--LATVGPLNLQSESMRYNVTT 966

  Fly   274 ---PFKILRLFVREKLRERVFTVSVPQLALHVPRKALPIHLGGTLEVDHATWLLSCRQSMT--NR 333
               |.|.|::     :.....|:||....:.||:.        .:.|::|..:.| ..:||  |.
Zfish   967 MPDPVKNLKV-----VSTTTNTISVTWKMVDVPKY--------VVSVNNAVKITS-SNNMTIHNL 1017

  Fly   334 EDELLANIVGVGGGSGSGSAAGSAAIVSTNGTETEA-----ATTAATI--ISAV----------- 380
            :.....||              |....:.:.||.||     .|.||.:  ::.|
Zfish  1018 QPSTQYNI--------------SVQSSTFDNTEGEAVCLQDCTDAAPVENVTCVGPNLTLPMLNL 1068

  Fly   381 ---HQLGD----------------------------NNTTVVTVSN-GVGPAGSASG-GATTAAS 412
               |.||.                            |.|..||:.. |.|.:.:... ..||..:
Zfish  1069 FWNHPLGGYMNFEVNLSSSISEKTKNLNYNFTGLKYNKTYSVTLRTLGCGKSSTVKNISCTTGFT 1133

  Fly   413 AATEPNENITINGLSPSHRQ-----AANNSSSSSSSAATVANPLKLNTSGS---ADNNSTITN-- 467
            ....|.    |...|.|.:|     ....|.:.:.|..||.:...|.:|||   .|||.....
Zfish  1134 NPVVPK----ITAASVSEQQYNKFALVIQSDAFNDSNGTVCSYGLLVSSGSFDCLDNNQNYNQCL 1194

  Fly   468 ----------------ATTAAGAAGAAAGTTTNGGGEFWS------------------------- 491
                            |......:.:...|...|.|..|:
Zfish  1195 LKTYDDWKAKQSDTFLAVVKTNVSKSELETIIIGDGSKWNKYTNGELNAKGTYNFAIVAFTLLEV 1259

  Fly   492 -----------------------ENPP--SSASSGFS---------------------------D 504
                                   |||.  ..|::|..                           .
Zfish  1260 KDGKVDVSKSYYSVSAYQSVTLPENPVVIGGAAAGVGVTVIIVVIIIGIVACTRKKRKEVSNSVP 1324

  Fly   505 DDSLAGQEGDPKPIDQIVQMVKQRGRH---GLIKEYADIRNRAPEGTFLHARMRANLTKNRYTDV 566
            ..||..:..||..::......|::...   |..:|:.|:|......:...|....|..||||.:|
Zfish  1325 IHSLRNKVSDPIKVEDYEAYYKRQRADSFCGFAEEFEDLRPVGINQSKTVAVFPENKAKNRYNNV 1389

  Fly   567 LCYDHSRVVLAHEDGDEP-SDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVM 630
            |.||.|||.|:..  ..| .||||||::.||..|..:|:.|||||.|..||||:|||::...|||
Zfish  1390 LPYDSSRVKLSVL--SSPFDDYINANYMPGYITKKEFIAAQGPLPGTVNDFWRLIWEKNVHTIVM 1452

  Fly   631 TTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQF 695
            .|:..|:|||||.:|| |.|..:  |.:..|.|||....||:.:...|::|:||.|||:|.|:.|
Zfish  1453 LTKCNEQGRVKCEEYW-PAEMKT--FSNLTVTTISDIPLEDWTLRDFEVKNMKTAEIRSVRHFHF 1514

  Fly   696 TSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDI 760
            |:|||:|||.:...::||...|||..        |.::.|   .|.:||||||:|||||||.:|.
Zfish  1515 TAWPDHGVPETTELLINFRHLVREHM--------DEYSRH---SPTLVHCSAGVGRTGTFIAIDR 1568

  Fly   761 CISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSR 808
            .|.::|..|..|:.|.:..:|..|...:|..|||||.:...::...||
Zfish  1569 LIFQIERDGVVDVYGIIHDLRMHRPLMVQTEDQYVFLNQCAMDIIKSR 1616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	1/29 (3%)
		SEC14	170..314	CDD:469559	36/173 (21%)
		PTPc-N9	529..799	CDD:350391	115/273 (42%)
ptprja	NP_001129714.1	fn3	102..168	CDD:394996
		FN3	158..676	CDD:442628	3/11 (27%)
		FN3	707..783	CDD:473895	15/89 (17%)
		FN3	968..1031	CDD:214495	17/90 (19%)
		PTP_tm	1157..1279	CDD:465889	16/121 (13%)
		R-PTPc-J	1384..1611	CDD:350463	108/242 (45%)