Protein Alignment Ptpmeg2 and Ptprh

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: XP_011248936.1
• Gene: Ptprh / 545902
• MGIID: 3026877
• Length: 1153
• Species: Mus musculus
• Alignment Length: 795
• Identity: 199/795 - (25%)
• Similarity: 311/795 - (39%)
• Gaps: 145/795 - (18%)

  Fly    53 NCSTTTATSPSTSSSSASSTQNLIAV----VPPQLQQLQVQLPAPGGGGGAGAGGGGGGGGGAAP 113
            |.||...::|:...:.....||.|::    .||....||          |..........||...
Mouse   418 NTSTVPISAPNPVRNLRVEGQNNISISLSWEPPDQPSLQ----------GLTYWAQCSRHGGQTE 472

  Fly   114 VRRHISHTTAVKFLYARKFDIPRAVSLYEQHEQIRLKEYLYNIDPDVEPLRSELQTGKFTILPAR 178
            .|.....:..|..|        ...|.||....:. |:.:|:.:   |.|.:.........|..:
Mouse   473 TRNTTDTSITVDGL--------DPGSSYECSVWVE-KDGVYSTN---ETLSNTTAPNPVRNLRVK 525

  Fly   179 TSSGAAIALFTANRHSPLSVSHTTTLQGIVYQLDSALQDSETQRAGLV------------FIYDM 231
            :.:..:|:|.......|       :|||::|....:....:|:.....            |:|..
Mouse   526 SQNNFSISLSWEPPDQP-------SLQGLIYWAQCSRHGGQTETRNTTDTSVTVDGLDPGFLYKC 583

  Fly   232 SGSKYSNFDYDLSQKILTLLKGGYPARLKKVLIVTAPLWFKAPFKILRLFVREKLRERVFTVSVP 296
            |               :.:.|.|..:..:.:...|.|:....|.:.||:..:..     |::|
Mouse   584 S---------------VWVEKDGVYSTNETLNTSTVPISASNPVRNLRVEGQNN-----FSIS-- 626

  Fly   297 QLALHVPRKALPIHLGGTLEVDHATWLLSCRQSMTNREDELLANIVGVGGGSGSGSAAGSAAIVS 361
             |:...|.::         .:...|:...|.:.....|....|:......|...||:...:..|.
Mouse   627 -LSWEPPDQS---------SLQGLTYWAQCSRHGGQTETRNTADTSVTVDGLDPGSSYECSVWVE 681

  Fly   362 TNGT-ETEAATTAATIISAVHQLGDNNTTVVTVSNGVG-------PAGSASG-----GATTAASA 413
            .:|. .|......:|:.:||     |.|:.::.|.|.|       |:|....     |....:..
Mouse   682 KDGVYSTNETLNTSTVPAAV-----NITSCISTSGGYGVLLTWSCPSGGYESFEVKVGRKWRSEN 741

  Fly   414 ATEPNENITINGLSPSHRQAANNSSSSSSSAATVANPLKLNTSGSADNNSTITNATTAAGAAGAA 478
            .:...:.:|::.|.|        :.|.:::..||...||      |.:.||..:..:||..|||.
Mouse   742 GSLCGKGVTVSDLEP--------AQSYTATVTTVFKDLK------AQSLSTTCHTESAAIIAGAI 792

  Fly   479 AGTTTNGGGEF-------------WSENPPSSASSGFSDDDSLAGQEGD--PKPIDQIVQMVKQR 528
            .|...    .|             ..:..|.....     |.:....||  .|.....|:..::.
Mouse   793 VGILL----LFILVGLLIVFLKRRRKKRQPKEVPK-----DLVCSCPGDILAKDFADHVRENEKD 848

  Fly   529 GRHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFV 593
            ...|..:||..:.......:.:.|....|.:||||.:||.||.|||.|.....:..||||||:|:
Mouse   849 SNCGFAEEYQQLALEGQGQSQITASALENRSKNRYRNVLPYDWSRVPLQPLQEEPGSDYINASFM 913

  Fly   594 DGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGD 658
            .|......:|:||||||.|..|||||:|||....:||.|..||.|||||..|| |.:......|.
Mouse   914 PGLWSPKEFIATQGPLPNTVGDFWRMVWEQQSHTLVMLTNCMESGRVKCEHYW-PLDAQPCIHGQ 977

  Fly   659 YHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQ 723
            ..|..||.|.:|::.|..|:|.::|..:..::..:.:.:|||:|||.|...:|.|.:.:|:...|
Mouse   978 LQVMLISEEASENWTVRHLQLFHMKEQQTLSLRQFHYLAWPDHGVPYSPDPLLAFRKMLRQWMDQ 1042

  Fly   724 LVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSI 788
            ...|          |||| ||||||:|||||.|.||:.:.:||..|.......|:|:|..|...:
Mouse  1043 TTDG----------GPPI-VHCSAGVGRTGTLIALDVLLRQLECEGLVGPFSFVKKMRESRPLMV 1096

  Fly   789 QMPDQYVFCHLALIE 803
            |...||||.|..:::
Mouse  1097 QTEAQYVFLHQCILK 1111

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	6/29 (21%)
		SEC14	170..314	CDD:469559	23/155 (15%)
		PTPc-N9	529..799	CDD:350391	106/269 (39%)
Ptprh	XP_011248936.1	FN3	<23..337	CDD:442628
		FN3	202..779	CDD:442628	78/440 (18%)
		PTP_DSP_cys	881..1113	CDD:475123	101/243 (42%)