DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg2 and csw

DIOPT Version :9

Sequence 1:	NP_572576.1	Gene:	Ptpmeg2 / 31907	FlyBaseID:	FBgn0028341	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_477131.1	Gene:	csw / 45278	FlyBaseID:	FBgn0000382	Length:	945	Species:	Drosophila melanogaster

Alignment Length:	732	Identity:	165/732 - (22%)
Similarity:	236/732 - (32%)	Gaps:	326/732 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   325 SCRQSMTNREDELLANIVGVGGGSGSGSAAGSAAIVSTN------------GTETEAATTAATII 377
            :|:..||:  |||...|.||..|          |....|            ..:..||.:|:|..
  Fly   102 ACKNCMTH--DELAQIIKGVAKG----------ADAQRNRDNRLQRRRRPLSAQPSAAASASTST 154

  Fly   378 SAVHQLGDNNTTVVTVSNGVGPAGSASGGATTAASAATEPNENITINGLSPSHRQAANNSSSSSS 442
            .::|:|              .|:..||..||..:..||.|.......|        |:.|:|:.|
  Fly   155 ESLHRL--------------TPSPQASYPATPTSWTATPPQFPAAFGG--------ASCSNSTLS 197

  Fly   443 SAATVANPL------KLNTSGSADNNSTITNATTAAGAAGAAAGTTTNGGGEFWSENPPSSASSG 501
            ..||:...|      ..|.||.......:...              .||
  Fly   198 LLATMRVQLHGYTWFHGNLSGKEAEKLILERG--------------KNG---------------- 232

  Fly   502 FSDDDSLAGQEGDPKPIDQIVQ----------MVKQRGR---------HGLIKEYADIRNRAPE- 546
                 |...:|...||.|.::.          |::.:.:         .|.:.|..|...|.|.
  Fly   233 -----SFLVRESQSKPGDFVLSVRTDDKVTHVMIRWQDKKYDVGGGESFGTLSELIDHYKRNPMV 292

  Fly   547 ---GTFLHARMRANLT----------------------------------------------KNR 562
               ||.:|.|...|.|                                              |||
  Fly   293 ETCGTVVHLRQPFNATRITAAGINARVEQLVKGGFWEEFESLQQDSRDTFSRNEGYKQENRLKNR 357

  Fly   563 YTDVLCYDHSRV-VLAHEDGDEPSDYINANFV----DG-------------------------YK 597
            |.::|.|||:|| :|..|.....::|||||::    ||                         ..
  Fly   358 YRNILPYDHTRVKLLDVEHSVAGAEYINANYIRLPTDGDLYNMSSSSESLNSSVPSCPACTAAQT 422

  Fly   598 QKN-------------------------------------------------------------- 600
            |:|
  Fly   423 QRNCSNCQLQNKTCVQCAVKSAILPYSNCATCSRKSDSLSKHKRSESSASSSPSSGSGSGPGSSG 487

  Fly   601 --------------------------------------------------------AYISTQGPL 609
                                                                    .||:|||.|
  Fly   488 TSGVSSVNGPGTPTNLTSGTAGCLVGLLKRHSNDSSGAVSISMAEREREREREMFKTYIATQGCL 552

  Fly   610 ----PKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECNE 670
                ..|..|||.|:|:::..||||||:..|||:.||.:|| |.|..|.:||...::.:|.....
  Fly   553 LTQQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYW-PDEGRSEQFGHARIQCVSENSTS 616

  Fly   671 DYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGH 735
            ||.:... |.:.:....|.:.|:.|..|||:|||:....:|||||.|..:|:.|.|      ||.
  Fly   617 DYTLREF-LVSWRDQPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQ------AGE 674

  Fly   736 PRGPPIVVHCSAGIGRTGTFITLDICISRLEDVG---TADIRGTVEKIRSQRAYSIQMPDQYVFC 797
            ..| ||.||||||||||||||.:|:.:.::...|   ..||:.|::.:||||:..:|...||.|.
  Fly   675 KPG-PICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFV 738

  Fly   798 HLALIEYAYSRGMLQTV 814
            :.|:..|      :||:
  Fly   739 YYAVQHY------IQTL 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024
		SEC14	170..314	CDD:238099
		Y_phosphatase	557..803	CDD:278528	108/446 (24%)
		PTPc	559..803	CDD:238006	107/444 (24%)
csw	NP_477131.1	SH2_C-SH2_SHP_like	211..307	CDD:198185	20/130 (15%)
		PTPc	326..744	CDD:214550	106/426 (25%)
		PTPc	543..743	CDD:238006	85/208 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443554
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840