Protein Alignment Ptpmeg2 and Ptpn3

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: XP_001059757.1
• Gene: Ptpn3 / 362524
• RGDID: 1311363
• Length: 1018
• Species: Rattus norvegicus
• Alignment Length: 874
• Identity: 205/874 - (23%)
• Similarity: 331/874 - (37%)
• Gaps: 223/874 - (25%)

  Fly   113 PVRRHISHTTAVKFLYARKFDIPRAVSLYEQHEQIRLKEYLYNIDPDVEPLRSELQTGKFT---- 173
            |:|:.:.........:..::.||...:|  |.||.|   :||.:.     |:.::..|:.|
  Rat   195 PLRKQLKGGLPCILHFRVRYFIPDPNTL--QQEQTR---HLYFLQ-----LKMDVCEGRLTCPLN 249

  Fly   174 --ILPARTSSGAAIALFTANRHSPLSVSHTTTLQGIVYQLDSALQDSET---QRAGLVFIYDMSG 233
              ::.|..:..:.|..|.::.|.|   .:....|.|..|.|..|...|:   |.:||.  ...:.
  Rat   250 SAVVLASYAVQSHIGDFNSSIHHP---GYLADSQFIPDQNDDFLSKVESLHEQHSGLK--QSEAE 309

  Fly   234 SKYSN----FDY---------DLSQKILTLLKGGYPARL---KKVLIVTAPLW---FKAPFKILR 279
            |.|.|    .|:         ||..  |.|:.|...|.:   :|.:..:...|   .|..||..:
  Rat   310 SCYINIARTLDFYGVELHGGRDLHN--LDLMIGIASAGIAVYRKYICTSFYPWVNILKISFKRKK 372

  Fly   280 LFVREK-----LRERVFTVS--------------VPQLALHVPRKALPIHLGGTLEVDHATWLLS 325
            .|:.::     .||.:...:              |...:....:|.||    ....|....|.|.
  Rat   373 FFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHSFFQAKKLLP----QEKNVLSQYWTLG 433

  Fly   326 CRQSMTNREDELLANIVGVGGGSGSGSAAGSAAIVSTNGTETEAATTAATIIS------------ 378
            .|....:..::....::|     |..........:|....||::..:.:..|:
  Rat   434 SRNPKKSVNNQYCKKVIG-----GMVWNPVMRRSLSVERLETKSLPSRSPPITPNWRSPRLRHEI 493

  Fly   379 --AVHQLGDNNTTVVTVSNGVGPAGSASGGATTAASAATEPNENITINGLSPSHRQAANN--SSS 439
              ..|...||....:|.............|:.:...:.:|.::|.:.:..|.|....|.:  :..
  Rat   494 RKPRHSSADNLANEMTYITETEDVFYTYKGSLSPKDSDSEVSQNHSPHRGSLSENNPAQSCLTQK 558

  Fly   440 SSSSAATVAN-PLKLNTSGSADNNSTITNATTAAGAAGAAA------------------------ 479
            ||||.:..:| |...:..|.........:..|..|:...|:
  Rat   559 SSSSVSPCSNAPGSFSPDGVDQQFLEDYHKVTKGGSIEEASQYYCDKNDDGDGYLVLIRITPDKE 623

  Fly   480 ---GTTTNGG---------GEFWSENPPSSASSGFSDDDSLA---GQEGDPKPIDQIVQMVK-QR 528
               |....||         .....|:|..:.....::.|.:.   |::......||:|..:| .|
  Rat   624 GRFGFNLKGGVDQKMPLVVSRINPESPADTCMPKLNEGDQIVLINGRDISEHTHDQVVMFIKASR 688

  Fly   529 GRHG----------LIKEYADIRNR--------------APEG---------------------- 547
            ..|.          .::..|:||:.              .|||
  Rat   689 ESHSRELALVIRRKAVRSLAEIRSEDELSQLFPEAMFPACPEGGDSLEGSMELLKKGLESGTVLI 753

  Fly   548 --------------TFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVD---- 594
                          ||  |::..||.||||.|||.||.:||:|   .|:|  |||||::|:
  Rat   754 QFEQLYRKKPGLAVTF--AKLPQNLDKNRYKDVLPYDTTRVLL---QGNE--DYINASYVNMEIP 811

  Fly   595 GYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDY 659
            .....|.||:||||||.|...||:::|:|...::||.|.:.||||.||.||| |.....::.|.:
  Rat   812 AANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLVVMLTTLTERGRTKCHQYW-PDPPDIMDHGIF 875

  Fly   660 HVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQL 724
            |::..:.:|...|:...:.:.|.:|.|...|:|.|:.:|||:|||..:...|.|::.||..:.
  Rat   876 HIQCQAEDCTIAYVSREMLVTNTETGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVKYVRSLRV-- 938

  Fly   725 VQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLE---DVGTADIRGTVEKIRSQRAY 786
                        .|.|.:|||||||||||..:|::..:..:|   .|...||   |.|:|.|||.
  Rat   939 ------------GGEPALVHCSAGIGRTGVLVTMETAMCLIERNLPVYPLDI---VRKMRDQRAM 988

  Fly   787 SIQMPDQYVFCHLALIEYAYSRGMLQTVD 815
            .:|...||.|...|::. .|..|::||:|
  Rat   989 MVQTSSQYKFVCEAILR-VYEEGLVQTLD 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	4/29 (14%)
		SEC14	170..314	CDD:469559	38/190 (20%)
		PTPc-N9	529..799	CDD:350391	107/336 (32%)
Ptpn3	XP_001059757.1	B41	135..327	CDD:214604	32/146 (22%)
		FERM_C_PTPN4_PTPN3_like	321..414	CDD:270010	15/94 (16%)
		PDZ_PTPN3-4-like	611..700	CDD:467190	13/88 (15%)
		PTPc-N3	736..1009	CDD:350448	102/298 (34%)