Protein Alignment Ptpmeg2 and Pez

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_609013.1
• Gene: Pez / 33882
• FlyBaseID: FBgn0031799
• Length: 1252
• Species: Drosophila melanogaster
• Alignment Length: 991
• Identity: 210/991 - (21%)
• Similarity: 327/991 - (32%)
• Gaps: 300/991 - (30%)

  Fly     1 MQQTQWNKDRQEDRNNNSGSRSE-----QDSGCHRRLFLCIAKAVKQFIDLCNNLGANCSTTTAT 60
            |||.|..:.:|...:|.|.:.|.     |.|.|               :||.||...:.|.....
  Fly   368 MQQQQQIQQQQMISSNISLATSANQMLGQSSSC---------------LDLSNNNLHSSSGMLHH 417

  Fly    61 SPSTSSSSASSTQNLIAVVP-----PQLQ---QLQVQLP------------APGGGGGAGAGGGG 105
            ..|.::::....:.|.|::|     |..:   ||:.:.|            |||....||:....
  Fly   418 GGSNNNNNNDERERLKAMLPTYRPAPDYETAVQLKYRTPSAEFHNVALAMAAPGNAYYAGSQPDV 482

  Fly   106 GGGG---------------------GAAPVRRHI----------SH----TTAVKFL-------- 127
            ...|                     .||.:..||          ||    :.|..:|
  Fly   483 HNPGMHNENLLYGHMTAHRYPDVAQPAAALHHHINLYQAQHQPQSHPQPMSPAQAYLELSQRMHM 547

  Fly   128 --------YARKFD----------IPRAVSLYEQHEQIRLKEYLYNIDPDVEPLRSELQTGKFTI 174
                    |..:..          .||.:..:        :.|:....||:...|:....|::..
  Fly   548 MRHKAPPPYVNRLSSSSTPDLAVATPRPLQGF--------RNYVSGSSPDLVSNRTLFNGGQYVA 604

  Fly   175 LPA-------RTSSGAAIALFTANRHSPLSVSHTTTLQ-------------------GIVYQL-D 212
            |||       .|||||.:.      |....|||....|                   .|:.|| .
  Fly   605 LPAGGHAGNIPTSSGATML------HQYQYVSHMGHSQPYLPPHGTFENLNMIEEQPSIMSQLRQ 663

  Fly   213 SALQDSETQRAGLVFIYDMSGSKYSNFDYDLSQKILTLLKGGY------PARLKKVLIVTAPLWF 271
            ||:..:....||.|                ::|...||...||      ||        ::||
  Fly   664 SAMSQAAAAAAGSV----------------VTQSSPTLPPSGYRSSVPPPA--------SSPL-- 702

  Fly   272 KAPFKILRLFVREKLRERVFTVSVPQLALHVPRKALPIHLGGTLEVDHATWLLSCRQSMTNREDE 336
                                   .|.:.....:.|.|..|               ::|:.|...|
  Fly   703 -----------------------PPPVVASSHKSATPAPL---------------QRSLVNGSIE 729

  Fly   337 -LLANIVGVGGGSGSGSAAGSAAIVSTNGTETEAATTAATIISAVHQLGDNNTTVVTVSNGVGPA 400
             :..|:......||..|.|.:...:....:..::| .....:.|......||...|||::.....
  Fly   730 PIYENVPLPQRASGGSSGAANTEAMRQRASSIQSA-PGVVPVPAARNASSNNVVTVTVNSPPDDG 793

  Fly   401 GSASGGATTAASAA---TEPNENITIN---------GLSPSHRQAANNSSSSSSSAATVANP--- 450
            .....||..|||..   .||......|         |.:|..||..:.:|.:.||...:..|
  Fly   794 NIKKYGADRAASTELLFLEPQAPKRTNRAASAAPDMGATPPPRQHRSTASLNKSSTVDMITPAGD 858

  Fly   451 ----------LKLNTSGSADN--NSTITNATTAAGAA---------------------------G 476
                      |..|||.|..:  |||:.  ||::.||                           |
  Fly   859 TLQQQFSAMNLSANTSASTSSMFNSTLD--TTSSSAASKDLKRKKRWNFLSRSKTPDKQKSATLG 921

  Fly   477 AAAGTTTNGGGEFWSE--------NPPSSASSGFSDDDSLAGQEGDPKPIDQIVQMVKQR-GRHG 532
            ....||.....:..::        |.|:..|:|.:....::|:...    |::.|::.|: ....
  Fly   922 REKATTAGQHSKLAAKLKLAQDDLNLPNRWSTGVNKPQPISGRYSK----DKLCQILDQKLSDSQ 982

  Fly   533 LIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVD--- 594
            |..|:..|..|.....:..|.:..|..||...:.|.||.:||.|. ...|....|:||:.:.
  Fly   983 LFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLT-PCRDNRHGYVNASSISATV 1046

  Fly   595 GYKQKNAYISTQGPL-PKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGD 658
            |.||: .||..|.|. |.|.:.||:.:||....::|..|..|        .|........||||.
  Fly  1047 GTKQR-FYIVAQSPQEPLTMRIFWQCVWEADVYLVVQLTEDM--------SYIPRNSHQRLEFGQ 1102

  Fly   659 YHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQ 723
            :.|.....:..:......|.|.::.:...|:|.:.|:..|.:...|......|:||:::...:..
  Fly  1103 FQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLA 1167

  Fly   724 LVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSI 788
            ..|   :...||...||:::||..|.||:|..:|.|:.:..|:.....||...:.::|.||...|
  Fly  1168 STQ---EVPPGHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSII 1229

  Fly   789 QMPDQYVFCHLALIEY 804
            ....||.|.:..||.|
  Fly  1230 PSLAQYKFIYNLLITY 1245

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	9/69 (13%)
		SEC14	170..314	CDD:469559	35/176 (20%)
		PTPc-N9	529..799	CDD:350391	73/273 (27%)
Pez	NP_609013.1	FERM_F1_PTPN14_like	17..107	CDD:340619
		FERM_M	112..230	CDD:459788
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009
		PTP_DSP_cys	1036..1246	CDD:475123	61/222 (27%)