Protein Alignment Ptpmeg2 and PTPN18

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: XP_006712480.1
• Gene: PTPN18 / 26469
• HGNCID: 9649
• Length: 464
• Species: Homo sapiens
• Alignment Length: 298
• Identity: 111/298 - (37%)
• Similarity: 154/298 - (51%)
• Gaps: 60/298 - (20%)

  Fly   529 GRHG--LIKEYADIR----------------NRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVV 575
            ||.|  |..|::||:                ...||          |:.||||.|||.||.:||:
Human    20 GREGAVLAGEFSDIQACSAAWKADGVCSTVAGSRPE----------NVRKNRYKDVLPYDQTRVI 74

  Fly   576 LA--HEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERG 638
            |:  .|:|.  |||||.||:.|.....|||:||||||.|..||||::||....||:|..|.:|.|
Human    75 LSLLQEEGH--SDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENG 137

  Fly   639 RVKCGQYWEPTEESSLEFGDYHVRTISVE-CNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYG 702
            |.:|.:|| ..|:..|:.|.:.:..|..: .|||.|:.:|::...|  |.|:|...|:.||||.|
Human   138 RKRCERYW-AQEQEPLQTGLFCITLIKEKWLNEDIMLRTLKVTFQK--ESRSVYQLQYMSWPDRG 199

  Fly   703 VPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPRGP-PIVVHCSAGIGRTGTFITLD----ICI 762
            ||||...||..:::.|..|..              || |:.||||||.||||...|:|    :.:
Human   200 VPSSPDHMLAMVEEARRLQGS--------------GPEPLCVHCSAGCGRTGVLCTVDYVRQLLL 250

  Fly   763 SRL--EDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCH 798
            :::  .|....|:   |.|:|.||..::|..:||.|.:
Human   251 TQMIPPDFSLFDV---VLKMRKQRPAAVQTEEQYRFLY 285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024
		SEC14	170..314	CDD:469559
		PTPc-N9	529..799	CDD:350391	111/298 (37%)
PTPN18	XP_006712480.1	PTPc-N18	27..292	CDD:350451	107/291 (37%)