Protein Alignment Ptpmeg2 and PTPN22

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_057051.4
• Gene: PTPN22 / 26191
• HGNCID: 9652
• Length: 807
• Species: Homo sapiens
• Alignment Length: 288
• Identity: 98/288 - (34%)
• Similarity: 145/288 - (50%)
• Gaps: 28/288 - (9%)

  Fly   519 DQIVQMVKQRGRHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDE 583
            ::.:::.:|..::...|.|.......|:          |:.||||.|:|.||:|||.|:....||
Human    26 NEFLKLKRQSTKYKADKTYPTTVAEKPK----------NIKKNRYKDILPYDYSRVELSLITSDE 80

  Fly   584 PSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEP 648
            .|.||||||:.|.....|||:|||||..|..||||||||...|:|||.....|.|:.||.:||..
Human    81 DSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAE 145

  Fly   649 TEESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNF 713
            ..|..||||.:.|...:.:...||::.:|:::  ...|.|.:..:.:.:|||:.||||...:|..
Human   146 PGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVK--FNSETRTIYQFHYKNWPDHDVPSSIDPILEL 208

  Fly   714 LQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLED---VGTADIRG 775
            :..||..|             .....||.:|||||.||||....:|.....|:|   .....:..
Human   209 IWDVRCYQ-------------EDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFS 260

  Fly   776 TVEKIRSQRAYSIQMPDQYVFCHLALIE 803
            .:.::|:||...:|..:||...:.|::|
Human   261 LIREMRTQRPSLVQTQEQYELVYNAVLE 288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024
		SEC14	170..314	CDD:469559
		PTPc-N9	529..799	CDD:350391	95/272 (35%)
PTPN22	NP_057051.4	PTPc-N22	57..290	CDD:350450	93/247 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	676..700
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	724..746