Protein Alignment Ptpmeg2 and Ptprc

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_612516.2
• Gene: Ptprc / 24699
• RGDID: 3451
• Length: 1273
• Species: Rattus norvegicus
• Alignment Length: 801
• Identity: 198/801 - (24%)
• Similarity: 299/801 - (37%)
• Gaps: 237/801 - (29%)

  Fly   165 SELQTGKFTILPARTSSGAAIALFTANRHSPLSVSHTTTLQGIVYQLDSALQDSETQRAGLVFIY 229
            :::.:|.....||.::.|.|              |:|||...|.........|.:.....:.:||
  Rat   157 TDISSGANLTTPAPSTLGFA--------------SNTTTSTEIATPQTKPSCDEKFGNVTVRYIY 207

  Fly   230 D---------MSGSKYSNFDY-----------DLSQKILTLLKGGYPARLKKVLIVTAPLWFKAP 274
            |         :.|.|....:|           :.|||.:||..|..                 .|
  Rat   208 DDSSKNFNANLEGDKKPKCEYTDCEKELKNLPECSQKNVTLSNGSC-----------------TP 255

  Fly   275 FKILRLFV------------------------REKLRERVFTVSVPQLALH---VPR-KALPIHL 311
            .||:.|.|                        ..|::.: ||..:.:::.:   .|. |...:..
  Rat   256 DKIINLDVPPGTHNFNLTNCTPDIEANTSICLEWKIKNK-FTCDIQKISYNFRCTPEMKTFALDK 319

  Fly   312 GGTLEVDHATWL--LSCRQSMTNREDELLANIVGVGGGSGSGSAAGSAAIVSTNGTETEAATTAA 374
            .|||      ||  |:.|.:.|...:.|..|::               .:......:|:..|..
  Rat   320 HGTL------WLHNLTVRTNYTCAAEVLYNNVI---------------LLKQDRRVQTDFGTPE- 362

  Fly   375 TIISAVHQLGDNNTTVVTVSNGVGPAGSASGGATTAASAATEPNENIT-------INGLSP---- 428
               ...|....|:|...|:.:...||....|.........:|..||:.       :..|.|
  Rat   363 ---MLPHVQCKNSTNSTTLVSWAEPASKHHGYILCYKKTPSEKCENLANDVNSFEVKNLRPYTEY 424

  Fly   429 --------SHRQAANNSSSSSSSAATVANPLKLN---TSGSADNNSTIT-------NATTA---- 471
                    ..|...|..:...:.....|.|.|:|   ||.::||:..:|       |...|
  Rat   425 TVSLFAYVIGRVQRNGPAKDCNFRTKAARPGKVNGMKTSRASDNSINVTCNSPYEINGPEARYIL 489

  Fly   472 -AGAAGAAAGTTTNGGGEFWSEN-------------------------PPSSA------------ 498
             ..:.|:...|......:|..:|                         |.|::
  Rat   490 EVKSGGSLVKTFNQSTCKFVVDNLYYSTDYEFLVYFYNGEYLGDPEIKPQSTSYNSKALIIFLVF 554

  Fly   499 -----------------------SSGFSDDDSLAGQEG-------DPKPIDQIVQMVKQR----G 529
                                   ||...:...|..::.       ||...|.:::..|::    |
  Rat   555 LIIVTSIALLVVLYKIYDLRKKRSSNLDEQQELVERDEEKQLINVDPIHSDLLLETYKRKIADEG 619

  Fly   530 RHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVD 594
            |. .:.|:..|.....:.....||...|..||||.|:|.||::||.|:..:||..|.||||:::|
  Rat   620 RL-FLAEFQSIPRVFSKFPIKDARKSQNQNKNRYVDILPYDYNRVELSEINGDAGSTYINASYID 683

  Fly   595 GYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDY 659
            |:|:...||:.|||..:|..|||:|||||...||||.||..|..|.||.:||...||.:..|
  Rat   684 GFKEPRKYIAAQGPRDETVDDFWKMIWEQKATVIVMVTRCEEGNRNKCAEYWPCMEEGTRTF--- 745

  Fly   660 HVRTISVECNE-----DYMVASLELRNIKTDEI-RNVSHWQFTSWPDYGVPSSAMAMLNFLQKVR 718
              |.:.|..|:     ||::..|.:.:.|.... |.|:|.|||||||:|||...    :.|.|:|
  Rat   746 --RDVVVTINDHKRCPDYIIQKLSIAHKKEKATGREVTHIQFTSWPDHGVPEDP----HLLLKLR 804

  Fly   719 EKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQ 783
            .:    |....:.::|     |||||||||:|||||:|.:|..:..||..|..|:.|.|..:|.|
  Rat   805 RR----VNAFSNFFSG-----PIVVHCSAGVGRTGTYIGIDAMLESLEAEGKVDVYGYVVNLRRQ 860

  Fly   784 RAYSIQMPDQYVFCHLALIEY 804
            |...:|:..||:..|.||:||
  Rat   861 RCLMVQVEAQYILIHQALVEY 881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024
		SEC14	170..314	CDD:469559	33/191 (17%)
		PTPc-N9	529..799	CDD:350391	110/275 (40%)
Ptprc	NP_612516.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	45..192		10/48 (21%)
		PHA03255	82..>191	CDD:165513	10/47 (21%)
		CD45	203..259	CDD:432641	14/72 (19%)
		FN3	366..431	CDD:238020	12/64 (19%)
		FN3	454..534	CDD:238020	14/79 (18%)
		Wzy_O6_O28	521..>580	CDD:468211	3/58 (5%)
		R-PTPc-C-1	676..876	CDD:350405	89/217 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	960..984
		R-PTP-C-2	986..1191	CDD:350406
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1219..1273