Protein Alignment Ptpmeg2 and Ptprz1

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: XP_006505075.1
• Gene: Ptprz1 / 19283
• MGIID: 97816
• Length: 2318
• Species: Mus musculus
• Alignment Length: 980
• Identity: 242/980 - (24%)
• Similarity: 371/980 - (37%)
• Gaps: 282/980 - (28%)

  Fly    60 TSPSTSSSSASSTQNL-----------IAVVPPQLQQLQVQLPAPGGGGGAGAGGGGGGGGGAA- 112
            ||.|.||..:...::|           ::.||..:..:|....|....|......|......||
Mouse  1096 TSVSISSMKSVFPESLVYPTTKGFEQGVSHVPEIIFPVQPTHTASQASGDTWLKPGLSANSEAAF 1160

  Fly   113 --PVRRHISHTTAVKFLY--ARKFDIPRAV--SLYEQHEQIRLKEYLYNI--DPDVEPLRSELQT 169
              ...|.:.|.:....||  |..|:....:  |.........||..|.::  ||.:.......|:
Mouse  1161 SDTASREVVHPSTQPLLYEAATPFNTEALLQPSFQASDVDTLLKTALPSVPSDPILAGTPQVEQS 1225

  Fly   170 GKFTILPARTSSGAAIAL--FTANRHSPLSVS--HTTTLQGIV-------YQLDSALQDSETQRA 223
            ......|..:.||::.::  ||:.....:|.|  |:|.|||:.       :.....|:....|:
Mouse  1226 SSSVSHPMASESGSSESMLHFTSVPILDISPSKVHSTPLQGLTVPHSSKKFSEQGLLKSKSPQQ- 1289

  Fly   224 GLVFIYDMSGSKYSNFDY------DLSQKILTLLKGGYPARLKKVLIVTAPLWFKAPFKIL--RL 280
                   :..|.:||.::      |:||        .||.:.:.. .||..|....|...|  :|
Mouse  1290 -------VLPSLFSNDEFFQSAHLDVSQ--------AYPPKGRHA-FVTPVLSIDEPQNTLINKL 1338

  Fly   281 FVRE--------KLRERVFTVSVPQLALHVPRKALPIHLGGTLEVDHATWLLSCRQSMT----NR 333
            ...|        .:.::|.| .:|.||..|        |..|   ||:..|.|...|:|    ||
Mouse  1339 VYSEDIFSSTEISITDKVLT-GLPTLASDV--------LSST---DHSVPLGSGPISLTMVSPNR 1391

  Fly   334 EDELL---------------------ANIVGVGGGSG---------------------------- 349
            :|.:.                     |::|| ||..|
Mouse  1392 DDSVTTAKLLLPSTATSKLTQSARSDADLVG-GGEDGDDYDDDDYDDIDRGRFPVNKCMSCLPYR 1455

  Fly   350 -------SGSAAGSAAIVSTN---------GTETEAATTAATII--------------------- 377
                   :.|....:::|..:         .||.|...|..|.:
Mouse  1456 ESREKVMNDSDTQESSLVDQSDPISPLLFENTEEENGGTGVTRVDKSPPPSMLPQNHNDGKEDSD 1520

  Fly   378 ----SAV--HQLGDNNTTVVT----VSNGVGPAGSASGGATTAASAATEPNENITINGLSPSHRQ 432
                |||  |..|.....|:|    ..:|.|.:.|.:...|:...:..:.||..|...|......
Mouse  1521 IQMGSAVLPHTPGSKAWAVLTSDEESGSGQGTSDSLNDNETSTDFSFPDVNEKDTDGVLETDDTG 1585

  Fly   433 AANNSSSSSSSAATVANPLKLNTSGSADNNSTITNATTAAGAAGAAAGTTTN------------- 484
            .|..|..||:.:.|..:      ||.::::....:.::.....|.|.|..:.
Mouse  1586 IAPGSPRSSTPSVTSGH------SGVSNSSEAEASNSSHESRIGLAEGLESEKKAVIPLVIVSAL 1644

  Fly   485 ---------GGGEFWSE------------------NPPSSASSGFSDDDSLAGQEGDPKPIDQIV 522
                     |...:|.:                  :.|.:.....|||......:..||.:..:
Mouse  1645 TFICLVVLVGILIYWRKCFQTAHFYLEDNTSPRVISTPPTPIFPISDDIGAIPIKHFPKHVADL- 1708

  Fly   523 QMVKQRGRHGLIKEYADIRNRAPEGTFLHARMRA---------NLTKNRYTDVLCYDHSRV---V 575
                 ...:|..:|:..::....|.....|.:..         |..||||.:::.||||||   .
Mouse  1709 -----HASNGFTEEFETLKEFYQEVQSCTADLGITADSSNHPDNKHKNRYVNIVAYDHSRVKLTQ 1768

  Fly   576 LAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRV 640
            ||.:|| :.:||||||:||||.:..|||:.||||..|::||||||||.:..||||.|.::|:||.
Mouse  1769 LAEKDG-KLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRR 1832

  Fly   641 KCGQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEI--------------RNVS 691
            ||.||| ||:.|. |:|.:.|...||:....|.|.:..|||.|..::              |.|:
Mouse  1833 KCDQYW-PTDGSE-EYGSFLVNQKSVQVLAYYTVRNFTLRNTKLKKLSELFQGSQKGRSSGRLVT 1895

  Fly   692 HWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFI 756
            .:.:|.|||.|||..::.:|.|::|..:.:...|             .|:|||||||:|||||:|
Mouse  1896 QYHYTQWPDMGVPEYSLPVLAFVRKAAQAKRHAV-------------GPVVVHCSAGVGRTGTYI 1947

  Fly   757 TLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSRGMLQTVDLAGFDE 821
            .||..:.:::..||.:|.|.::.|||||.|.:|..:||||.|..|:|...|:           :.
Mouse  1948 VLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSK-----------ET 2001

  Fly   822 REPDS 826
            ..|||
Mouse  2002 EVPDS 2006

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	7/33 (21%)
		SEC14	170..314	CDD:469559	36/170 (21%)
		PTPc-N9	529..799	CDD:350391	116/295 (39%)
Ptprz1	XP_006505075.1	alpha_CARP_receptor_like	45..298	CDD:239396
		fn3	313..401	CDD:394996
		PTP_DSP_cys	1714..1997	CDD:475123	118/298 (40%)
		R-PTP-Z-2	2080..2283	CDD:350507