Protein Alignment Ptpmeg2 and Ptprt

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: XP_017172075.1
• Gene: Ptprt / 19281
• MGIID: 1321152
• Length: 1487
• Species: Mus musculus
• Alignment Length: 946
• Identity: 242/946 - (25%)
• Similarity: 358/946 - (37%)
• Gaps: 288/946 - (30%)

  Fly    56 TTTATSPSTSSSSASSTQNLIAVVPPQLQQLQVQLPAPGGGGGAGAGGGGGGGG----------- 109
            |||.|...|.... |....|..:.|....:::|.|..|      |.||.|..|.
Mouse   333 TTTGTWAETHIVD-SPNYKLWHLDPDVEYEIRVLLTRP------GEGGTGPPGPPLTTRTKCADP 390

  Fly   110 ------------------------GAAPVRRHISHTTAVKFLYA---RKFDIPRAVSLYEQHE-- 145
                                    |.|..|.| |:...|::.|.   ::::....:.....:.
Mouse   391 VHGPQNVEIVDIRARQLTLQWEPFGYAVTRCH-SYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLR 454

  Fly   146 ------QIRLKEYLYNID----------------PDVEPLRSELQTGKF------TILPARTSSG 182
                  .|||:..|.|.:                |...||.| :|.|.|      ...|...::|
Mouse   455 GLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLES-IQGGPFEEKIYIQWKPPNETNG 518

  Fly   183 AAIALFTANRHSPLSVSHTTTL---QGIVYQLDSALQDSETQR------AGLVFIYDMSGSKYSN 238
             .|.|:..|..:..|:..:..|   :|.|::|     .:||..      .|..:.:.:..|....
Mouse   519 -VITLYEINYKAVGSLDPSADLSSQRGKVFKL-----RNETHHLFVGLYPGTTYSFTIKASTAKG 577

  Fly   239 FDYDLSQKILTLLKG----GYPARL------KKVLIVTAPLWFK-APFKILRLFVREKLRER--- 289
            |...::.:|.|.:..    .|.|..      ..:.::..|...: ||..:.:|.|:|:..::
Mouse   578 FGPPVTTRIATKISAPSMPEYDADTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRR 642

  Fly   290 ------VFTV-----------SVPQLALHVPRKALPIHLGGTLEVDHATW----------LLSCR 327
                  .|:|           |:...|..:....||:....|:. |:.|:          |.|..
Mouse   643 AADIIECFSVPVSYRNASNLDSLHYFAAELKPSNLPVTQPFTVG-DNKTYNGYWNPPLSPLKSYS 706

  Fly   328 ---QSMTNREDELLANIVGVGGGSGSGSAAGSAAIVSTNGTETEAATTAATIISAVHQLGDNNTT 389
               |:::....|...|.|.:...:..|||.      .|.||.....||.|:.        .|:.|
Mouse   707 IYFQALSKANGETKINCVRLATKAPMGSAQ------VTPGTPLCLLTTGAST--------QNSNT 757

  Fly   390 V---VTVSNGVGPAGSASG---------GATTAASAATEPNENITI----NGLSPSH----RQAA 434
            |   ..|.|.|..||..:|         |..            :||    |..|.|:    |:.|
Mouse   758 VEPEKQVDNTVKMAGVIAGLLMFIIILLGVM------------LTIKRRRNAYSYSYYLSQRKLA 810

  Fly   435 NNSSSSSSSAATVANPLKLNTSGSADNNSTITNATTAAGAAGAAAGTTTNGGGEFWSENPPSSAS 499
            .....:.|.|.....|:     .|.|..:             |..||..|..| |.|.   |...
Mouse   811 KKQKETQSGAQREMGPV-----ASTDKPT-------------AKLGTNRNDEG-FSSS---SQDV 853

  Fly   500 SGFSDDDSLAGQEG-----------------DP----KPIDQ-------------IVQMVKQRGR 530
            :||:|     |..|                 ||    .|.||             |.||.:.:|
Mouse   854 NGFTD-----GSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQG- 912

  Fly   531 HGLIKEYADIRNRAPEG---TFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANF 592
            :|..:||..:    |||   ::..|:...|..||||.:::.||||||.|...|||..|||||||:
Mouse   913 YGFKEEYEAL----PEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANY 973

  Fly   593 VDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGR------------------ 639
            :|||.:...||:||||:.:|.:|||||||:::...|||.|.::|.||
Mouse   974 IDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRHPAEHTVGTATLGRAASP 1038

  Fly   640 --VKCGQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYG 702
              |||.:||....|   .:||..|..|..|...:|::.:..::.....|||.:..:.||||||:|
Mouse  1039 GMVKCVRYWPDDTE---VYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHG 1100

  Fly   703 VPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLED 767
            ||..|..:|.|:::|:             :...|...|||||||||.||||.||.:|..:...|:
Mouse  1101 VPCYATGLLGFVRQVK-------------FLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAEN 1152

  Fly   768 VGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIE 803
            .|..||...|.::|:||...:|..:||||.|.|::|
Mouse  1153 EGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE 1188

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	5/32 (16%)
		SEC14	170..314	CDD:469559	33/189 (17%)
		PTPc-N9	529..799	CDD:350391	112/292 (38%)
Ptprt	XP_017172075.1	MAM	36..193	CDD:214533
		Ig	200..285	CDD:472250
		fn3	298..364	CDD:394996	8/31 (26%)
		FN3	394..484	CDD:238020	12/90 (13%)
		fn3	506..581	CDD:394996	15/80 (19%)
		R-PTPc-T-1	936..1192	CDD:350478	107/269 (40%)
		R-PTPc-T-2	1277..1482	CDD:350482