Protein Alignment Ptpmeg2 and Ptprm

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_001344554.1
• Gene: Ptprm / 19274
• MGIID: 102694
• Length: 1486
• Species: Mus musculus
• Alignment Length: 941
• Identity: 225/941 - (23%)
• Similarity: 341/941 - (36%)
• Gaps: 270/941 - (28%)

  Fly    58 TATSPSTSSSSASSTQNLIAVVPPQLQ-QLQVQLPAPGGGGGAGAGGGGGGGGGAAPVRRHISHT 121
            ||:..........||...|..:.|..: ::.|.|..||       .||.|..|.|...|.    .
Mouse   322 TASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPG-------EGGTGSPGPALRTRT----K 375

  Fly   122 TAVKFLYARKFDIPRAVSLYEQHEQIRLKEYLYNID---------------PDVEPLRSELQTG- 170
            .|......||.::   |.:..:...||.:.:.||:.               ...|.:|.|:...
Mouse   376 CADPMRGPRKLEV---VEVKSRQITIRWEPFGYNVTRCHSYNLTVHYGYQVGGQEQVREEVSWDT 437

  Fly   171 -----KFTILPARTSSGAAIALFTAN-----RHSPLSVS---------HTTTLQGIVYQLDSALQ 216
                 :.||......:..::.|...|     ....|:|.         .|.::||..::....||
Mouse   438 DNSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELTVQTDEDLPGAVPTESIQGSAFEEKIFLQ 502

  Fly   217 DSE-TQRAGLVFIYDMSGSKYSNFD--YDLSQKI----------------------------LTL 250
            ..| ||..|::.:|:::....|:||  .|||.:.                            .:.
Mouse   503 WREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRAST 567

  Fly   251 LKG-GYPARLKKVLIVTAP-------------------LWFK------APFKILRLFVREKLRER 289
            .|| |.||..:....::||                   :..|      ||..:.::.|.|:...|
Mouse   568 AKGFGPPATNQFTTKISAPSMPAYEFETPLNQTDNTVTVMLKPAQSRGAPVSVYQIVVEEERPRR 632

  Fly   290 V---------------------------FTVSVPQLALH---------------------VPRKA 306
            .                           |....|..:|.                     :|.|:
Mouse   633 TKKTTEILKCYPVPIHFQNASILNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPHKS 697

  Fly   307 LPIHLGGTLEVDHATWLLSCRQSMTNRE---DELLANIVGVGGGSGSGSAAGSAA-------IVS 361
            ..|:.......:..| .:.|.:..|...   .:|....:.:...:|.|...|:..       ...
Mouse   698 YRIYYQAASRANGET-KIDCVRVATKAAIIVTQLTTPYIRIAPAAGDGQLTGAVTPKPVPEPEKQ 761

  Fly   362 TNGTETEAATTAATIISAVHQLGDNNTTVVTVSNGVGPAGSASGGATTAASAATEPNENITINGL 426
            |:.|...|...|..::..:..||     ||.|   :.....|.....|.:|  |.....:.:|.:
Mouse   762 TDHTVKIAGVIAGILLFVIIFLG-----VVLV---MKKRKLAKKRKETMSS--TRQEMTVMVNSM 816

  Fly   427 SPSHRQAANNSSSSSSSAAT-------VANP----LKLNTSGSADNNS---------TITNAT-T 470
            ..|:.:...|...:.|...|       |::|    :|.||..::..||         .|.:.| |
Mouse   817 DKSYAEQGTNCDEAFSFMGTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDPFVPTAILDETHT 881

  Fly   471 AAGAAGAAAGTTTNGGGEFWSENPPSSASSGFSDDDSLAG--------------QEGDPKP---- 517
            .|                              ||..|||.              |.|...|
Mouse   882 MA------------------------------SDTSSLAQPHTYKKREAADVPYQTGQLHPAIRV 916

  Fly   518 ---IDQIVQMVKQRGRHGLIKEYADI--RNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLA 577
               :..|.||....| :|..:||...  ...||..:   |:...|..||||.:::.||||||.|.
Mouse   917 ADLLQHITQMKCAEG-YGFKEEYESFFEGQSAPWDS---AKKDENRMKNRYGNIIAYDHSRVRLQ 977

  Fly   578 HEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKC 642
            ..:||..|||||.|::|||.:.|.||:||||:.:|..|||||:|.::...|:|.|.::|.|||||
Mouse   978 MLEGDNNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKC 1042

  Fly   643 GQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSA 707
            .:||....|.   :.|..|..|..|...:|::.:..:......|||.:..:.||.|||:|||..|
Mouse  1043 CKYWPDDTEI---YKDIKVTLIDTELLAEYVIRTFAVEKRGIHEIREIRQFHFTGWPDHGVPYHA 1104

  Fly   708 MAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTAD 772
            ..:|.|:::|:.|..             |...|:|||||||.||||.||.:||.:...|..|..|
Mouse  1105 TGLLGFVRQVKSKSP-------------PNAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVD 1156

  Fly   773 IRGTVEKIRSQRAYSIQMPDQYVFCHLALIE 803
            |...|.::||:|...:|..:||||.|.|::|
Mouse  1157 IYNCVRELRSRRVNMVQTEEQYVFIHDAILE 1187

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	5/29 (17%)
		SEC14	170..314	CDD:469559	41/268 (15%)
		PTPc-N9	529..799	CDD:350391	107/271 (39%)
Ptprm	NP_001344554.1	MAM	22..182	CDD:214533
		ig	192..274	CDD:395002
		FN3	<266..>638	CDD:442628	62/329 (19%)
		fn3	499..574	CDD:394996	16/74 (22%)
		R-PTPc-M-1	918..1190	CDD:350481	113/290 (39%)
		R-PTPc-M-2	1276..1481	CDD:350483