Protein Alignment Ptpmeg2 and Ptprc

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_001104786.2
• Gene: Ptprc / 19264
• MGIID: 97810
• Length: 1293
• Species: Mus musculus
• Alignment Length: 932
• Identity: 228/932 - (24%)
• Similarity: 349/932 - (37%)
• Gaps: 266/932 - (28%)

  Fly    56 TTTATSPSTSSSSASSTQN------LIAVVPPQLQQLQVQLPAPGGGGG------------AGAG 102
            ||.:|.||.|.....|::.      |..::|....|...|.|:.||...            ..|.
Mouse    53 TTESTPPSISERGNGSSETTYHPGVLSTLLPHLSPQPDSQTPSAGGADTQTFSSQADNPTLTPAP 117

  Fly   103 GGGGGGGGAAPVRRHISHTTAVKFLYARKFDIPRAVSLYEQHEQIRLKEYLYNIDPDVEPLRSEL 167
            |||....| .|..|.:..|            ||              .:..:.:|.......|..
Mouse   118 GGGTDPPG-VPGERTVPGT------------IP--------------ADTAFPVDTPSLARNSSA 155

  Fly   168 QTGKFTILPART--SSGAAIALFT------ANRHSPLSVSHTTTLQ---------GIVYQLDSAL 215
            .:...|...:.|  ||||::...|      |:...|.:...|||.|         .:.|..:|:
Mouse   156 ASPTHTSNVSTTDISSGASLTTLTPSTLGLASTDPPSTTIATTTKQTCAAMFGNITVNYTYESS- 219

  Fly   216 QDSETQRAGLVFIYDMSGSKYSNFDYDLSQKILTLLKGGYPARLKKVLIVTAPLWFKAPFKILRL 280
              ::|.:|.|   .|:..:|..|.|   .:.:|..|:  ..:::|.:.:.....   ||...:.|
Mouse   220 --NQTFKADL---KDVQNAKCGNED---CENVLNNLE--ECSQIKNISVSNDSC---APATTIDL 271

  Fly   281 FV---REKL-------RERVFTVSVPQLALHVPRKALPIHLGGTLEVDHATWLLSCR-------- 327
            :|   .:|.       :|:..|    .:.|....|.|...   ....|:.:::|.|.
Mouse   272 YVPPGTDKFSLHDCTPKEKANT----SICLEWKTKNLDFR---KCNSDNISYVLHCEPENNTKCI 329

  Fly   328 ---------------QSMTN---------REDELLANIVGVGGGSG--------SGSAAGSAAIV 360
                           ::.||         |..:|:.|::.|....|        .|..|....:|
Mouse   330 RRNTFIPERCQLDNLRAQTNYTCVAEILYRGVKLVKNVINVQTDLGIPETPKPSCGDPAARKTLV 394

  Fly   361 STNGTETEAATTAATIISAVHQLGDNNTTVVTVSNGVGPAGSASGGATTAASAATEPNENITING 425
            |.           ...:|........:..|:...|......|.....|:....:.:|.:...::.
Mouse   395 SW-----------PEPVSKPESASKPHGYVLCYKNNSEKCKSLPNNVTSFEVESLKPYKYYEVSL 448

  Fly   426 LSPSHRQAANNSSSSSSSAATVAN-PLKLN---TSGSADNNSTITNATTAAGAAGAAAGTTT--- 483
            |:..:.:...|.::...:..|.|: |.|:|   ||...||:..:|     .|......|..|
Mouse   449 LAYVNGKIQRNGTAEKCNFHTKADRPDKVNGMKTSRPTDNSINVT-----CGPPYETNGPKTFYI 508

  Fly   484 ----NGGG----------EFWSENPPSSAS--------SGFSDDDSLAGQEG------------- 513
                :||.          :|:.:|...|..        :|..:.||:...|.
Mouse   509 LVVRSGGSFVTKYNKTNCQFYVDNLYYSTDYEFLVSFHNGVYEGDSVIRNESTNFNAKALIIFLV 573

  Fly   514 --------------------------------------------DPKPI--DQIVQMVKQR---- 528
                                                        |.:||  |.:::..|::
Mouse   574 FLIIVTSIALLVVLYKIYDLRKKRSSNLDEQQELVERDDEKQLMDVEPIHSDILLETYKRKIADE 638

  Fly   529 GRHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFV 593
            ||. .:.|:..|.....:.....||...|..||||.|:|.||::||.|:..:||..|.||||:::
Mouse   639 GRL-FLAEFQSIPRVFSKFPIKDARKPHNQNKNRYVDILPYDYNRVELSEINGDAGSTYINASYI 702

  Fly   594 DGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGD 658
            ||:|:...||:.|||..:|..|||||||||...||||.||..|..|.||.:||...||.:..|.|
Mouse   703 DGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFKD 767

  Fly   659 YHVRTISVECNE-----DYMVASLELRNIKTDEI-RNVSHWQFTSWPDYGVPSSAMAMLNFLQKV 717
                 |.|..|:     ||::..|.:.:.|.... |.|:|.|||||||:|||...    :.|.|:
Mouse   768 -----IVVTINDHKRCPDYIIQKLNVAHKKEKATGREVTHIQFTSWPDHGVPEDP----HLLLKL 823

  Fly   718 REKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRS 782
            |.:    |....:.::|     |||||||||:|||||:|.:|..:..||..|..|:.|.|.|:|.
Mouse   824 RRR----VNAFSNFFSG-----PIVVHCSAGVGRTGTYIGIDAMLEGLEAEGKVDVYGYVVKLRR 879

  Fly   783 QRAYSIQMPDQYVFCHLALIEY 804
            ||...:|:..||:..|.||:||
Mouse   880 QRCLMVQVEAQYILIHQALVEY 901

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	4/29 (14%)
		SEC14	170..314	CDD:469559	35/170 (21%)
		PTPc-N9	529..799	CDD:350391	113/275 (41%)
Ptprc	NP_001104786.2	PTP_N	7..31	CDD:403599
		DUF5585	<19..>181	CDD:465521	33/154 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	43..174		31/147 (21%)
		CD45	212..265	CDD:432641	12/66 (18%)
		FN3	393..451	CDD:238020	9/68 (13%)
		FN3	474..553	CDD:238020	17/83 (20%)
		R-PTPc-C-1	696..896	CDD:350405	92/217 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	980..1003
		R-PTP-C-2	1006..1211	CDD:350406
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1240..1293