Protein Alignment Ptpmeg2 and Ptpn4

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_064317.2
• Gene: Ptpn4 / 19258
• MGIID: 1099792
• Length: 926
• Species: Mus musculus
• Alignment Length: 906
• Identity: 224/906 - (24%)
• Similarity: 345/906 - (38%)
• Gaps: 283/906 - (31%)

  Fly   113 PVRRHISHTTAVKFLYARKFDIPRAVSLYEQHEQIRLKEYLYNIDPDVEPLRSELQTGKFTILPA 177
            |:|:.:...:.....:..||.:.....|.|::.:     |.|.:.     ::.::.||:.: .|.
Mouse    90 PIRKQLKRGSPYNLNFRVKFFVSDPNKLQEEYTR-----YQYFLQ-----IKQDILTGRLS-CPC 143

  Fly   178 RTSSGAAIALFTANRHSPL-SVSHTTTLQGIVYQLDSAL-----QDSE-------TQRAGL---- 225
            .|:  |.:|.|..  .|.| ..:.:..|.|  |..|.:.     ||.|       .|..||
Mouse   144 NTA--ALLASFAV--QSELGDYNQSENLAG--YLSDYSFIPNQPQDFEKEIAKLHQQHVGLSPAE 202

  Fly   226 -VFIY-------DMSGSKYSNFDYDLSQK--ILTLLKGG---YPARLKKVLIVTAPLWF---KAP 274
             .|.|       ::.|.:: ::..|.|..  ::.::.||   |..|::    :...||.   |..
Mouse   203 AEFNYLNAARTLELYGVEF-HYARDQSNNEILIGVMSGGILIYKNRVR----MNTFLWLKIVKIS 262

  Fly   275 FKILRLFVREKLRERVFTVSVPQLALHVPRKALPIHLGGTLE------------VDHATWLLSCR 327
            ||..:.|:  :||:.          ||..|:.|   ||..:.            |:|.|:....|
Mouse   263 FKCKQFFI--QLRKE----------LHESRETL---LGFNMVNYRACKTLWKACVEHHTFFRLDR 312

  Fly   328 ---------------------------QSMTNREDELLANIVGVGGGSGSGSAAGSA---AIVST 362
                                       ||:...:::  ||...|...|.|...|...   .:||.
Mouse   313 PLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEK--ANKDRVFARSPSKPLARKLMDWEVVSR 375

  Fly   363 NG-----TETEAA----------------TTAATII--SAVHQLGDNNTTVVTVSNGVGPAGSAS 404
            |.     .||::.                |..||.:  |:|..|.|:   ||.:|.........|
Mouse   376 NSLSDDRLETQSLPSRSPPGTPNHRNSSFTQEATRVRPSSVGHLVDH---VVHMSPSEDFVSQRS 437

  Fly   405 GGATTAASAATE--PNENITINGLSPS--HRQAANNS------SSSSSSAATVAN--------PL 451
            ..:|.|.|...|  |::....:|..|:  .:|:..||      |:|.....|..|        |.
Mouse   438 PSSTQANSIVLESSPSQETPEDGQPPALPPKQSKKNSWNQIHFSNSQQDLVTHTNESFDVPSSPE 502

  Fly   452 K--------------------------LNTSGSADNNSTITNATTAAGAAGAAAGTTTNGG---- 486
            |                          .|..|..|....:..:..|.|..........|.|
Mouse   503 KSTPNGGIPHDNLVLIKMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCVPRLNEGDQVV 567

  Fly   487 ---------------------------GE-------------------------FWSENPPSSAS 499
                                       ||                         :..|..|  ..
Mouse   568 LINGRDIAEHTHDQVVLFIKASCEKHSGELVLLVRPNAVYDVVEEKLESEPDFQYIPEKAP--LD 630

  Fly   500 SGFSDDDSLAGQEGDPKPIDQIVQMVKQRGRHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYT 564
            |...||.||.         :.::|:.:......::.::..:..:.|..|...|::..|::||||.
Mouse   631 SVHQDDHSLR---------ESMIQLAEGLITGTVLAQFDQLYRKKPGMTMSCAKLPQNISKNRYR 686

  Fly   565 DVLCYDHSRVVLAHEDGDEPSDYINANFVD----GYKQKNAYISTQGPLPKTSQDFWRMIWEQHC 625
            |:..||.:||:|   .|:|  ||||||:::    .....|.||:.|||||.|.:|||:|.|||..
Mouse   687 DISPYDATRVLL---KGNE--DYINANYINMEIPSSSIINQYIACQGPLPHTCKDFWQMTWEQGS 746

  Fly   626 LVIVMTTRVMERGRVKCGQYW-EPTEESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRN 689
            .::||.|..:|||||||.||| ||:|.||  :|.|.|...|.|.|..|:...:.|.|.:.:|.|.
Mouse   747 SMVVMLTTQVERGRVKCHQYWPEPSESSS--YGCYQVTCHSEEGNPAYIFRKMTLFNQEKNESRQ 809

  Fly   690 VSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGT 754
            ::..|:|:|||:|||..:...|:|:..||:::|             .:..||:|||||||||||.
Mouse   810 LTQIQYTAWPDHGVPDDSSDFLDFVCHVRDQRA-------------GKEEPIIVHCSAGIGRTGV 861

  Fly   755 FITLDICISRLE---DVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSRGMLQ 812
            .||::..:..:|   .|...||   |..:|.|||..||.|.||.|...|::: .|..|.::
Mouse   862 LITMETAMCLIECNQPVYPLDI---VRTMRDQRAMMIQTPSQYRFVCEAILK-VYEEGFVK 918

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	5/29 (17%)
		SEC14	170..314	CDD:469559	41/176 (23%)
		PTPc-N9	529..799	CDD:350391	110/277 (40%)
Ptpn4	NP_064317.2	B41	30..222	CDD:214604	30/149 (20%)
		FERM_C_PTPN4_PTPN3_like	216..310	CDD:270010	24/113 (21%)
		FA	324..365	CDD:462582	7/42 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	379..412		5/32 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	429..474		9/44 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	492..511		3/18 (17%)
		PDZ_PTPN3-4-like	513..602	CDD:467190	9/88 (10%)
		PTP_DSP_cys	641..914	CDD:475123	113/296 (38%)