Protein Alignment Ptpmeg2 and Ptpn2

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_001120649.1
• Gene: Ptpn2 / 19255
• MGIID: 97806
• Length: 406
• Species: Mus musculus
• Alignment Length: 276
• Identity: 112/276 - (40%)
• Similarity: 158/276 - (57%)
• Gaps: 19/276 - (6%)

  Fly   537 YADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNA 601
            |.:|||.:.:.....|:...|..:|||.||..||||||.|...:    :|||||:.||..:.:.:
Mouse    22 YLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQSTE----NDYINASLVDIEEAQRS 82

  Fly   602 YISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGD--YHVRTI 664
            ||.||||||.|...||.|:|:|....:||..|.:|:..|||.||| ||::..:.|.:  :.|:.:
Mouse    83 YILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRTVEKESVKCAQYW-PTDDREMVFKETGFSVKLL 146

  Fly   665 SVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLG 729
            |.:....|.|..|:|.||.|.|.|.:||:.:|:|||:|||.|..:.||||.||||.....
Mouse   147 SEDVKSYYTVHLLQLENINTGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGCLT----- 206

  Fly   730 DTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQY 794
                  |...|.|:||||||||:|||..:|.|:..:|.....:::..:..:|..|...||.|||.
Mouse   207 ------PDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGEDVNVKQLLLNMRKYRMGLIQTPDQL 265

  Fly   795 VFCHLALIEYA-YSRG 809
            .|.::|:||.| |::|
Mouse   266 RFSYMAIIEGAKYTKG 281

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024
		SEC14	170..314	CDD:469559
		PTPc-N9	529..799	CDD:350391	106/263 (40%)
Ptpn2	NP_001120649.1	PTP_DSP_cys	19..272	CDD:475123	106/265 (40%)
		Endoplasmic reticulum location. /evidence=ECO:0000250	341..406
		Mediates interaction with STX17. /evidence=ECO:0000250	371..406