Protein Alignment Ptpmeg2 and Ptpn13

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_035334.2
• Gene: Ptpn13 / 19249
• MGIID: 103293
• Length: 2451
• Species: Mus musculus
• Alignment Length: 952
• Identity: 234/952 - (24%)
• Similarity: 341/952 - (35%)
• Gaps: 273/952 - (28%)

  Fly    32 LFLC-IAKAVKQFID--LCNNLGANCSTTTATSPSTSSSSASSTQNLIAVVPPQLQQLQVQLPAP 93
            |.|| .|..|...||  ..|.|.:..::...:|..||..|:|..|
Mouse  1573 LLLCRPAPGVLPEIDTTFLNPLYSPANSFLNSSKETSQPSSSVEQ-------------------- 1617

  Fly    94 GGGGGAGAGGGGGGGGG------AAPVRR--HISHTTA--------------VKFLYARKFDIPR 136
                  ||.....|..|      .||.||  :..|:.:              |..:.|...:.||
Mouse  1618 ------GASSDDNGVSGKTKNHCRAPSRRESYSDHSESGEDDSVRAPAKMPNVTRVAAFPHEAPR 1676

  Fly   137 AVSLYEQHEQIRLKEYLYNIDP-------------DVEPLRSELQTGKFTILPARTSSGAAIALF 188
            :     |.|.|....||....|             ||.|       |:....||..:...|....
Mouse  1677 S-----QEESICAMFYLPRKIPGKLESESSHPPPLDVSP-------GQTCQPPAECAPSDATGKH 1729

  Fly   189 TANRHSPLS-VSHTTTLQGIVYQLDSALQDSE-----------TQRAGLVFIYDMSGSKYSNFDY 241
            ..:..|.|| ..:.|||:.   .|.:.|:|||           :::..|.|...........:.:
Mouse  1730 FTHLASQLSKEENITTLKN---DLGNHLEDSELEVELLITLVKSEKGSLGFTVTKGSQSIGCYVH 1791

  Fly   242 DLSQ---KILTLLKGGYPARLKKV---------------LIVTAPLWFKAPFKILRLF---VREK 285
            |:.|   |....||.|  .||.||               |:..||       |.:||.   :.|.
Mouse  1792 DVIQDPAKGDGRLKAG--DRLIKVNDTDVTNMTHTDAVNLLRAAP-------KTVRLVLGRILEL 1847

  Fly   286 LRERVFTVSVPQLALHVPRKALPIHLGGTLEVDHATWLLS----CRQSMTNREDELLANIVGVGG 346
            .|..||...:|.:.:....:.|...|.|.....|....:|    ...:..:...:||..|..|.|
Mouse  1848 PRMPVFPHLLPDITVTCHGEELGFSLSGGQGSPHGVVYISDINPRSAAAVDGSLQLLDIIHYVNG 1912

  Fly   347 GSGSGSAAGSA--AI----------VSTNGTETEAATTAATIISAVHQLGDNNTTVVTVS----- 394
            .|..|.....|  |:          |:.:|......|.||  |||......|..|.:..|
Mouse  1913 VSTQGMTLEDANRALDLSLPSVVLKVTRDGCPVVPTTRAA--ISAPRFTKANGLTSMEPSGQPAL 1975

  Fly   395 ---------NGVG------PAGSASGGATTAASAATE--------------PNENITINGLSPSH 430
                     ||.|      |||..|......::..||              |.|...|..|....
Mouse  1976 MPKNSFSKVNGEGVHEAVCPAGEGSSSQMKESAGLTETKESNSRDDDIYDDPQEAEVIQSLLDVV 2040

  Fly   431 RQAANNSSSSSSSAATVANPLKLNTSGSADNNSTITNATTAAGAAGAAAGTTTNGGGEFWSENPP 495
            .:.|.|..:...:.....:|..|.|:|.|...                 |.|...|... .|:.|
Mouse  2041 DEEAQNLLNQRHATRRACSPDPLRTNGEAPEE-----------------GDTDYDGSPL-PEDVP 2087

  Fly   496 SSASSGFSDDD--SLAGQEGDPKPIDQ----------------------------------IVQM 524
            .|.|||....|  ||.....:.|||::                                  .|..
Mouse  2088 ESVSSGEGKVDLASLTAASQEEKPIEEDATQESRNSTTETTDGEDSSKDPPFLTNEELAALPVVR 2152

  Fly   525 VKQRGRH-------------GLI------KEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYD 570
            |...|::             ||:      ||..:::...|....|..:.:.|..||||.::|.||
Mouse  2153 VPPSGKYTGTQLQATIRTLQGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYD 2217

  Fly   571 HSRVVLAHEDGDEPSDYINANFVD---GYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTT 632
            .:||.|..|.|     ||||:|:.   | .|:..||:.|||||.|..|||:|:|||:..||.|.|
Mouse  2218 TTRVPLGDEGG-----YINASFIRIPVG-TQEFVYIACQGPLPTTVGDFWQMVWEQNSTVIAMMT 2276

  Fly   633 RVMERGRVKCGQYWEPTEESSLEFGDYHVR--TISVECNEDYMVASLELRNIKTDEIRNVSHWQF 695
            :.:|..::||.:|| |:...:....:..:|  .:.::..:.::|..:.|.:|:|.|:|::||..|
Mouse  2277 QEVEGEKIKCQRYW-PSILGTTTMANERLRLALLRMQQLKGFIVRVMALEDIQTGEVRHISHLNF 2340

  Fly   696 TSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDI 760
            |:|||:..||....:|.|:..:|..:               |..|::.||||||||:||.|.:|:
Mouse  2341 TAWPDHDTPSQPDDLLTFISYMRHIR---------------RSGPVITHCSAGIGRSGTLICIDV 2390

  Fly   761 CISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALI 802
            .:..:......||...|..:|.||...:|...|||||:..::
Mouse  2391 VLGLISQDLEFDISDLVRCMRLQRHGMVQTEGQYVFCYQVIL 2432

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	7/45 (16%)
		SEC14	170..314	CDD:469559	40/176 (23%)
		PTPc-N9	529..799	CDD:350391	97/293 (33%)
Ptpn13	NP_035334.2	KIND	3..190	CDD:214801
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	183..227
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	253..285
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	429..457
		FERM_F1_PTPN13	564..659	CDD:340715
		B41	566..774	CDD:214604
		PH-like	770..870	CDD:473070
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	944..966
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1007..1063
		PDZ1_PTPN13-like	1081..1172	CDD:467285
		PTN13_u3	1168..1356	CDD:465189
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1199..1356
		PDZ2-PTPN13_FRMPD2-like	1354..1440	CDD:467254
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1441..1478
		PDZ3_PTPN13_FRMPD2-like	1489..1578	CDD:467181	3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1602..1662		15/85 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1695..1726		6/37 (16%)
		PDZ4_PTPN13-like	1760..1844	CDD:467182	18/92 (20%)
		PDZ5_PTPN13-like	1855..1941	CDD:467183	16/85 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1991..2024		6/32 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2051..2139		20/105 (19%)
		PTPc-N13	2202..2435	CDD:350445	90/253 (36%)