DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg2 and ZK354.8

DIOPT Version :9

Sequence 1:	NP_572576.1	Gene:	Ptpmeg2 / 31907	FlyBaseID:	FBgn0028341	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_500775.1	Gene:	ZK354.8 / 191295	WormBaseID:	WBGene00022709	Length:	483	Species:	Caenorhabditis elegans

Alignment Length:	342	Identity:	105/342 - (30%)
Similarity:	161/342 - (47%)	Gaps:	51/342 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   495 PSSASSGFSDDDSLAGQEGDPKPIDQI----VQMVKQRGRHGLIKEYADIRNRAPEG---TFLHA 552
            ||...:.....|...|  .|.|...::    :::|.|.|..||.|||.|..|.|||.   :||
Worm   161 PSKEKTDEKSVDETGG--SDKKKRTEVICSWIRLVLQNGVAGLKKEYRDSPNEAPEDIATSFL-- 221

  Fly   553 RMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFW 617
               .|.|:|||.::.|.|.:||.|.    |:|..||:||.|........:|.||.||..|.::||
Worm   222 ---GNPTRNRYRNIPCCDITRVKLT----DDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFW 279

  Fly   618 RMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECNEDY---MVASLEL 679
            :||.......|||...::|:|:.|..:|:......:.:.|  .:.|::.|...|.   :|.| .:
Worm   280 KMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIG--RLCTVTKESRVDIDKTLVMS-TM 341

  Fly   680 RNIKTDE---IRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPI 741
            |..|..:   ::.|.|..:.:|||:|||.:.::....|..|:...                 .||
Worm   342 RISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCT-----------------KPI 389

  Fly   742 VVHCSAGIGRTGTFITLDICISRLEDVGTADIRGT---VEKIRSQRAYSIQMPDQYVFCHLALIE 803
            |||||||:||||   ||.:.:..||.:...|..|.   :.|:|.:|..::|...||::.|..::|
Worm   390 VVHCSAGVGRTG---TLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLE 451

  Fly   804 YAYSRGMLQT-VDLAGF 819
            |...:..:|: .|.|.|
Worm   452 YLALKKYVQSREDFAKF 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024
		SEC14	170..314	CDD:238099
		Y_phosphatase	557..803	CDD:278528	78/254 (31%)
		PTPc	559..803	CDD:238006	77/252 (31%)
ZK354.8	NP_500775.1	PTPc	200..451	CDD:214550	90/282 (32%)
ZK354.8	NP_500775.1	PTPc	225..451	CDD:238006	77/252 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2394
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860