DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg2 and ptp-5.2

DIOPT Version :9

Sequence 1:	NP_572576.1	Gene:	Ptpmeg2 / 31907	FlyBaseID:	FBgn0028341	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_502779.1	Gene:	ptp-5.2 / 190372	WormBaseID:	WBGene00013304	Length:	482	Species:	Caenorhabditis elegans

Alignment Length:	511	Identity:	100/511 - (19%)
Similarity:	172/511 - (33%)	Gaps:	130/511 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   332 NREDELLANIVG--VGGGSGSGSAAGSAAIVSTNGT-------ETEA---------------ATT 372
            |::.:.||:...  |......|...||.....:.|.       ||.|               |.|
Worm    15 NKDGKALASTASKDVADPPKQGGTKGSKKPKPSRGNDEKGREPETSAQSKKAKKGKPKRDSKAAT 79

  Fly   373 AATIISAVHQLGDNNTTVVTVSNGVGPAGSASGGATTAASAATEPNENITINGLSPSHRQAANNS 437
            .|....:...|.|:....|.....:..|.|.:|..||....|..|.||.|
Worm    80 PALSPGSREMLSDHKKQTVEDDPPLPIATSVAGTVTTTGMPALLPAENAT--------------- 129

  Fly   438 SSSSSSAATVANPLKLNTSGSADNNSTITNATTAAGAAGAAAGTTTNGGGEFWSENPPSSASSGF 502
                       .|||          ..:.:...:.||..:|..|            |.|..|:..
Worm   130 -----------QPLK----------EVVNSGKKSKGAPNSATAT------------PVSHKSTIT 161

  Fly   503 SDDDSLAGQEGDPKPIDQI-VQMVKQRGRHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYTDV 566
            ...|...|::.....:|.| :..||        ||:..:::...:........:||...|:..|.
Worm   162 EGADKWVGEDVAKNWMDSIDLAEVK--------KEFEKLQSMKVDVEKECKTWKANSKYNQSEDF 218

  Fly   567 LCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCL---VI 628
            ...|.:.:.:       ..||:|.:.|:....:|.||. |.|:..|.:.||:.::::..:   ||
Worm   219 PALDSNLLKV-------EKDYVNISRVEIPLGRNIYIG-QVPVKDTEETFWKAVFDKRIVSIDVI 275

  Fly   629 VMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVE-CNEDYMVASLEL-----RNIKTDEI 687
            |....:         :::....|....:|...:....|| .::|....|:|:     .|.....:
Worm   276 VGDEPI---------EFFPKKAEDYKNYGQMWINNRKVEYVSDDVFRFSIEVLPHGCSNSIICNV 331

  Fly   688 RNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQ---GLGDTWAGHPRGPPIVVHCSAGI 749
            ..:|:|:..|.|                   .|||..::   ||.......|.....:::...|.
Worm   332 TVISNWKVDSVP-------------------VKQAIAIKEAFGLNSYLLKAPADDNAMINSQHGA 377

  Fly   750 GRTGTFITLDICISRLE-DVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEY 804
            ||.|.|:.|.:.:..:: .|....|...|:.|||||..::....||...:::|:.:
Worm   378 GRAGYFLALAVAVHTIDTKVAEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYF 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024
		SEC14	170..314	CDD:238099
		Y_phosphatase	557..803	CDD:278528	54/258 (21%)
		PTPc	559..803	CDD:238006	53/256 (21%)
ptp-5.2	NP_502779.1	PTPc	185..432	CDD:214550	59/290 (20%)
ptp-5.2	NP_502779.1	PTPc_motif	336..432	CDD:214649	26/114 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910