Protein Alignment Ptpmeg2 and R155.3

DIOPT Version :10

• Sequence 1: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_497485.1
• Gene: R155.3 / 187909
• WormBaseID: WBGene00020117
• Length: 1165
• Species: Caenorhabditis elegans
• Alignment Length: 1001
• Identity: 184/1001 - (18%)
• Similarity: 326/1001 - (32%)
• Gaps: 336/1001 - (33%)

  Fly     3 QTQWNKDRQEDRNNNSGSRSEQDSGCHRRLFLCIAKAVKQFIDLCNNLGANCSTTTATSPSTSSS 67
            :.:|.||...|.:.|                  :|.|:.|.           .|..|::.....|
 Worm   181 EDKWIKDAVRDHSGN------------------LANALNQL-----------KTFEASTRKVHQS 216

  Fly    68 SASSTQNLIAVVPPQLQQLQVQLPAPGGGGGAGAGGGGGGGGGAAPVRRH-ISHTTAVKFLYARK 131
            ..|.     ||:..::.:::.::|...|.....|         ..|.:.| |..|.:||...:.|
 Worm   217 FVSE-----AVMLEEVSKIRSKIPKYSGLADKIA---------TLPSKIHEILGTPSVKLPTSDK 267

  Fly   132 FDIPRAVSLYEQ--------------HEQIRLKEYLYNIDPDVEPLRSELQTGK----------- 171
            ..:.:|:.|..|              .||::|.|....:...:|.:.   |.||
 Worm   268 DKVDKAIPLMAQLPAQLKALEKLMNFSEQLKLPENAKKLGNIIEIVN---QDGKNQLENTLKMFK 329

  Fly   172 --------FT-ILPARTSSGAAIALFTANRHSPLSVSHTTTLQGIVYQLDSA---LQD------- 217
                    :| :||.:.:    :.|...|   |:   |.|. ..|:..||..   .||
 Worm   330 SSTDVKEIYTLLLPVKDT----LELLKDN---PI---HETA-ANIISSLDKVEKFAQDMADFFTA 383

  Fly   218 ----SETQRAGLVF--IYDMSGSKYSNFDYDLSQKI--LTLLK------GGYPARLKKVLIVTAP 268
                .:.:.:.|:.  |..:...:.||..:.|:..:  |.::|      ..|...:||..
 Worm   384 LNSIRQIEESSLIIPVITTIRQLRLSNDQFGLTTVLNNLPMIKTQLSSLTSYINSVKKTK----- 443

  Fly   269 LWFKAPFKILRLFVREKLRERVF---TVSVPQLALHVPRKALPIHLGGTL--EVDHATWLLSCRQ 328
               .|....|:.|.:..|..||.   |..:..:...|..|.| ..:|..:  ||:.....|:
 Worm   444 ---HAETDALKDFEKIGLHSRVIGTATRGISNMQKLVDFKDL-ADIGDLVKSEVEKVKDQLN--- 501

  Fly   329 SMTNREDELLANIVGVGGGSGSGSAAGSAAIVSTNGTETEAATTA-------------------- 373
                  ||.:||:..:.|..|....| |..||....:.....:|:
 Worm   502 ------DENVANLKALAGIEGQLKTA-SGEIVGYKKSVKPVTSTSLPDYSTFFLDAKKVKGINLK 559

  Fly   374 -ATIISAVHQLGDNNTTVVTVSNGVGPAGSASGGATTAASAATEPNENITINGLSPSHRQAANNS 437
             ..|||::.:|  ||...:..|.....:....|...:..|.:     :|::: .:..|:....::
 Worm   560 LPAIISSMEKL--NNLVPIRSSRATRSSTQLDGYLLSLQSLS-----SISLD-FTKFHKSFDGST 616

  Fly   438 SSSSSSAATVANPLKLNTSGSADNNSTITNATTAAGAAGAAAGTTTNGGGEFWSENPPSSASSGF 502
            .|......:.|.           .|:|:|....||.|..:..|:::..||           |.|.
 Worm   617 QSLQDLGVSFAK-----------YNNTLTKQKAAAAAQKSGGGSSSASGG-----------SQGV 659

  Fly   503 SDDDS-----LAG------------------QEGDPK----------PIDQIVQMVK-------- 526
            .:.:|     :.|                  .:.||.          |::::.:.||
 Worm   660 FESNSTIVLIVFGCIVFICVILIPASSWFYLHQKDPAARKCFAIRELPMEEVKKPVKKKDVSKMD 724

  Fly   527 -------QRGRHGLIKE---------------YADIRNRAPEG-------TFL------------ 550
                   ::.:...||:               |.|.|..|.:.       .||
 Worm   725 NKPERELEKTQDESIKDVPKLILELDMSSAEKYVDCRYEALQDMHKETCIPFLSEELIKKFYGVK 789

  Fly   551 ------------HARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFV---DGYKQKN 600
                        ...:::...|.|....|..| :||||.........|||:||.|   .|.:
 Worm   790 FDAMNEKYEVPGREALKSEQMKQRLPIPLVMD-TRVVLKDYGTLFNDDYIHANRVTCSHGLQ--- 850

  Fly   601 AYISTQGP-------LPKTSQDFWRMIWEQHCLVIVMTTRVMER--GRV-KCGQYWEPTEESSLE 655
             .|.:|.|       ...|.:.:|....::....:||.....|:  |:. .|.:|:..:...|::
 Worm   851 -LILSQAPQEANGESCESTIESYWWTAKQEKSTQLVMMCDFDEKCPGKTNSCARYYPESVGESMK 914

  Fly   656 FGDYHVRTISVEC-----NEDYMVASLELRNIKTD--EIRNVSHWQFTSWPDYGVPSSAMAMLNF 713
            |     :.::|||     .:|:....||   :|.|  |...|:|.:...|....|....:...:.
 Worm   915 F-----KNLTVECKSKIAEKDFETRELE---VKFDGHEPHTVTHSRLVGWNPLNVQPDTLLFTSL 971

  Fly   714 LQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISR-LEDVGTADIRGTV 777
            :||::....                 |::|||..||.|:..|.::.|.... ::.:|:..:...|
 Worm   972 IQKIKNSTT-----------------PVMVHCIDGISRSAAFASMIIGYQLVIQSLGSVKLEAVV 1019

  Fly   778 EKIRSQRAYSIQMPDQYVFCHLALIE 803
            ..||||||.:|....:..|....:::
 Worm  1020 SYIRSQRAMAITSALELAFVDAGIVK 1045

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	9/44 (20%)
		SEC14	170..314	CDD:469559	36/190 (19%)
		PTPc-N9	529..799	CDD:350391	70/336 (21%)
R155.3	NP_497485.1	PTPc	802..1045	CDD:214550	62/272 (23%)