DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg2 and C46A5.1

DIOPT Version :9

Sequence 1:	NP_572576.1	Gene:	Ptpmeg2 / 31907	FlyBaseID:	FBgn0028341	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_501277.1	Gene:	C46A5.1 / 183497	WormBaseID:	WBGene00016698	Length:	497	Species:	Caenorhabditis elegans

Alignment Length:	450	Identity:	108/450 - (24%)
Similarity:	178/450 - (39%)	Gaps:	81/450 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   382 QLGDNNTTVVTVSNGVGPAGSASGGATTAASAATEP-NENITINGLSPSHRQAANNSSSSSSSAA 445
            |||:    ||.|.|...|            ....:| |:....:||.|.....:....:.|..:.
Worm    86 QLGE----VVLVKNVKLP------------ETPQKPENDTPVKDGLKPPRTTNSVEKINLSKESF 134

  Fly   446 TVANPLKLNTSGSADNNSTITNATTAAGAAGAAAGTTTNGGGEFWSENPPSSASSGFSDDDSLAG 510
            .::|. |:.:....:......|..:.|.......|.:.....|...:.         :.||:..|
Worm   135 NLSNE-KIASDNGTEEKMEKKNVDSPADIQDGLKGKSKQKSEEKVHQK---------AKDDAKRG 189

  Fly   511 QEGDPKPIDQ--------IVQMVKQRGRHGLIKEYADIRNRAP----EGTFLHARMRANLTKNRY 563
            .|.:...|..        :.|...:...:..:.|:..:....|    :..|:     :|:.|||:
Worm   190 DECNKFKISDEKLTKWKLVAQETLKDDANIAVNEFEKVSGYLPPHISKNHFV-----SNMDKNRF 249

  Fly   564 TDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQ--HCL 626
            .||:|.|||||.|.      .|.||:||:||....|.| |.||.||..|:.|||:||.:|  .|:
Worm   250 VDVICMDHSRVKLT------DSSYIHANWVDLNSSKKA-ILTQLPLSHTASDFWQMIIDQKIKCV 307

  Fly   627 VIVMTTRVMER-GRVKCGQYWEPTEESSLEFGDYHVRT---ISVECNEDYMVASLELRNIKTDEI 687
            :::||.....: |    |....|..:..|:|.|..:|.   ..||..:.:.:..|.:.|......
Worm   308 LLIMTDGEFNKFG----GNSVFPQNQDFLKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTF 368

  Fly   688 RNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQG-LGDTWAGHPRGPPIVVHCSAGIGR 751
            .:|.|::  :||...:||..            ||...||. |.....||   ||:.:..| |.||
Worm   369 IHVHHYK--NWPHGSIPSDV------------KQIWQVQSYLRKYTDGH---PPVYMSMS-GCGR 415

  Fly   752 TGTFITLDIC-ISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSRGM 810
            .|||...:.. :|...:..:.::...:|.:|:.|.:|:|...|:...:..:.|:....|:
Worm   416 AGTFALFETAHMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGNGI 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024
		SEC14	170..314	CDD:238099
		Y_phosphatase	557..803	CDD:278528	77/253 (30%)
		PTPc	559..803	CDD:238006	76/251 (30%)
C46A5.1	NP_501277.1	Y_phosphatase	243..468	CDD:278528	77/253 (30%)
C46A5.1	NP_501277.1	PTPc	245..468	CDD:238006	76/251 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910